Systems and methods for making noninvasive physiological assessments
First Claim
1. A method for detecting a physiological property of a target tissue, comprising:
- noninvasively inducing a detectable tissue displacement at a central nervous system (CNS) target tissue site by applying an ultrasound pulse;
noninvasively determining the induced tissue displacement at or in proximity to the CNS target tissue site; and
relating the induced tissue displacement with a physiological property of the CNS target tissue.
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Accused Products
Abstract
Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and/or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.
451 Citations
54 Claims
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1. A method for detecting a physiological property of a target tissue, comprising:
- noninvasively inducing a detectable tissue displacement at a central nervous system (CNS) target tissue site by applying an ultrasound pulse;
noninvasively determining the induced tissue displacement at or in proximity to the CNS target tissue site; and
relating the induced tissue displacement with a physiological property of the CNS target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- noninvasively inducing a detectable tissue displacement at a central nervous system (CNS) target tissue site by applying an ultrasound pulse;
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21. A method for assessing intracranial pressure (ICP) in a subject, comprising:
- administering acoustic interrogation signals to a target CNS tissue site in the subject;
detecting at least one of an acoustic emission, an induced and an intrinsic target tissue displacement based on acoustic data acquired from the target CNS tissue site;
determining the arterial blood pressure (ABP) of the subject; and
relating at least one of the acoustic emission, the induced and the intrinsic target tissue displacement and ABP with ICP. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
- administering acoustic interrogation signals to a target CNS tissue site in the subject;
- 33. A system comprising an acoustic source and an acoustic detector, the acoustic source and detector being operably connected to a power source, the power source being operably connected to a function generator, and the function generator being operably connected to a controller having data acquisition, storage and analysis capability, the controller having the capability to process acquired acoustic data, make determinations of at least one of acoustic emission properties, induced and intrinsic tissue displacements and relate the determination of at least one of acoustic emission properties, induced and intrinsic tissue displacement(s) with at least one physiological tissue condition of a CNS target tissue, the controller being operably connected to a display device for displaying information relating to the at least one physiological tissue condition.
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42. A method for assessing a physiological property of a CNS target tissue, comprising the steps of:
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(a) acquiring acoustic data relating to intrinsic tissue displacements at the CNS target tissue site at multiple time points over the course of at least one cardiac cycle; and
(b) relating the intrinsic tissue displacements with a physiological property of the CNS target tissue. wherein said acoustic data is collected by using an ultrasound transducer. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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Specification