Microchip devices with improved reservoir opening

• US 6,875,208 B2
• Filed: 05/31/2002
• Issued: 04/05/2005
• Est. Priority Date: 05/31/2001
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Flynn, Nolan T., Cima, Michael J., Santini, John T. Jr., Sheppard, Norman F. Jr., Maloney, John M., Uhland, Scott A., Sbiaa, Zouhair
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US10/159,550
• Publication Number:
  US 20020183721A1
• Time in Patent Office: 1,040 Days
• Field of Search: 604/890.1, 604/891.1, 604/93.01, 128/898, 216/2, 216/39, 216/56
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: Y10T 137/8242 Electrical

Abstract

Microchip devices and methods of manufacture thereof are provided to increase the uniformity and reliability of active exposure and release of microchip reservoir contents. In one embodiment, the microchip device for the controlled release or exposure of molecules or secondary devices comprises: (1) a substrate having a plurality of reservoirs; (2) reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs; (3) reservoir caps positioned on the reservoirs over the reservoir contents; (4) electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and (5) a current distribution means, a stress induction means, or both, operably engaged with or integrated into the reservoir cap, to enhance reservoir cap disintegration.

Claims

1. A microchip device for the controlled release or exposure of molecules or secondary devices comprising:

a substrate;

a plurality of reservoirs in the substrate;

reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs;

reservoir caps positioned on the reservoirs over the reservoir contents;

electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and

a current distribution means, operably engaged with or integrated into each reservoir cap, to enhance reservoir cap disintegration,

wherein the current distribution means comprises a structure selected from the group consisting of structures for dispersing electrical current uniformly across each reservoir cap, structures for dispersing thermal energy uniformly across each reservoir cap, structures for increasing the exchange current density of each reservoir cap which operates as an electrode, and combinations thereof.

2. The device of claim 1, further comprising an cathode, wherein the reservoir caps each comprise a thin metal film which is an anode, the electrical activation means comprises a means for applying an electric potential between the cathode and the anode effective to cause the reservoir cap disintegration to occur electrochemically.

3. The device of claim 1, wherein the current distribution means comprises a current distribution network mounted on or integrated into the reservoir cap.

4. The device of claim 3, wherein the current distribution network comprises a plurality of traces fabricated onto a surface of the reservoir cap.

5. The device of claim 4, wherein the traces comprise a non-metal, conducting material.

6. The device of claim 4, wherein the traces comprise a metal.

7. The device of claim 6, wherein the reservoir cap comprises a thin metal film, the metal of which is the same as or different from the metal of the traces.

8. The device of claim 4, wherein the traces are coated with a passivating layer.

9. The device of claim 1, wherein the current distribution means comprises an electrochemically plated metal layer on the outer surface of the reservoir cap, said metal layer having increased surface roughness relative to said outer surface of the reservoir cap.

10. The device of claim 2, wherein the outer surface of the reservoir cap has been treated to increase the surface roughness of the outer surface.

11. The device of claim 1, wherein the reservoir contents comprise a drug.

12. The device of claim 1, wherein the reservoir contents comprises a secondary device.

13. The device of claim 1, wherein the electrical activation means comprises a microprocessor.

14. The device of claim 13, wherein the electrical activation means further comprises a power source.

15. A method of delivering reservoir contents to a site comprising:

providing the microchip device of claim 1 at a delivery site; and

activating said electrical activation means to initiate release of the reservoir contents from selected reservoirs of the microchip device.

16. A device for the controlled release or exposure of molecules or secondary devices comprising:

a substrate;

a plurality of reservoirs in the substrate;

reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs;

reservoir caps positioned on the reservoirs over the reservoir contents;

electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs;

at least one resistor operably adjacent the reservoir caps, wherein the electrical activation means comprises a means for applying an electric current through the resistor effective to cause the reservoir cap disintegration to occur thermally; and

a current distribution means or both a current distribution means and a stress induction means, operably engaged with or integrated into each reservoir cap, to enhance reservoir cap disintegration.

17. A device for the controlled release or exposure of molecules or secondary devices comprising:

a substrate;

a plurality of reservoirs in the substrate;

reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs;

reservoir caps positioned on the reservoirs over the reservoir contents;

electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and

a stress induction means operably engaged with or integrated into the reservoir cap, to enhance reservoir cap disintegration,

wherein the stress induction means comprises a pre-stressed structure attached to or integrated into the reservoir cap, the pre-stressed structure providing a force substantially perpendicular to the surface of the reservoir cap.

18. The device of claim 17, wherein the pre-stressed structure comprises a bilayer cantilever beam.

19. The device of claim 17, wherein the pre-stressed structure comprises a single layer of material, the layer having a stress gradient.

20. The device of claim 17, wherein the pre-stressed structure comprises a spring, coil, or cross design.

21. The device of claim 17, wherein the reservoir contents comprise drug molecules for release.

22. A device for the controlled release of molecules comprising:

a substrate;

a plurality of reservoirs in the substrate, each reservoir containing drug molecules for release;

a plurality of reservoir caps which comprise a thin metal film, enclosing each reservoir;

an electrical power source for selectively disintegrating each reservoir cap to release of the drug molecules; and

a current distribution network comprising a plurality of traces attached to a surface of the thin metal film of each reservoir cap.

23. The device of claim 22, wherein the traces comprise a corrodible material.

24. The device of claim 22, wherein the traces comprise a non-corrodible material.

25. The device of claim 22, wherein the traces are formed substantially of the same material as the material from which the reservoir caps are formed.

26. The device of claim 22, wherein the traces are formed substantially of a different material as the material from which the reservoir caps are formed.

27. A method for enhancing disintegration of a reservoir cap of a microchip device, the method comprising:

activating an electrical means to initiate disintegration of at least one reservoir cap located in a microchip device which comprises a substrate having a plurality of reservoirs, each reservoir having a reservoir cap positioned thereon, each reservoir containing molecules or secondary devices for controlled release or exposure; and

operating a current distribution means or a stress induction means or both a current distribution means and a stress induction means, operably engaged with or integrated into each reservoir cap, to enhance corrosion, internal stress, or both, of the reservoir cap.