Non-dispersive mid-infrared sensor for vaporized hydrogen peroxide

• US 6,875,399 B2
• Filed: 05/10/2002
• Issued: 04/05/2005
• Est. Priority Date: 05/11/2001
• Status: Expired due to Term

• Current Assignee: American Sterilizer Company (Steris Corporation)
• Original Assignee: Steris Corporation
• Inventors: McVey, Iain F.
• Primary Examiner(s): JASTRZAB, KRISANNE MARIE
• Application Number:
  US10/142,678
• Publication Number:
  US 20020168289A1
• Time in Patent Office: 1,061 Days
• Field of Search: 422/3, 422/4, 422/28, 422/105, 422/108, 422/110, 422/111, 250/339.13, 250/343
• US Class Current: 422/3
• CPC Class Codes: A61L 2/208 Hydrogen peroxide
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: A61L 2/28 Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour apparatus involving enzymes or microorganisms C12M1/34; methods involving enzymes or microorganisms C12Q1/00
• CPC Class Codes: A61L 2202/122 Chambers for sterilisation
• CPC Class Codes: A61L 2202/14 Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
• CPC Class Codes: A61L 2202/21 Pharmaceuticals, e.g. medicaments, artificial body parts
• CPC Class Codes: A61L 2202/24 Medical instruments, e.g. endoscopes, catheters, sharps

Abstract

A sterilization system (14) includes a sensor (10) for detection of a component, such as hydrogen peroxide vapor, in a multi-component vapor, such as a mixture of vapor hydrogen peroxide and water supplied to a chamber (12) of the system. The sensor preferably uses a wavelength range in which hydrogen peroxide strongly absorbs but other components of the vapor, such as water, do not. A suitable wavelength for detection of hydrogen peroxide is from about 7500 to about 8400 nm, since there is little absorption by water in this range. This avoids the need to use complex subtraction procedures normally used to remove the contribution of water from detected absorbance measurements. A control system (16, 30) controls operating conditions of the sterilization system, such as a heater (82), pressure release valves (74), vaporization rate of hydrogen peroxide by a vaporizer (22), and the like to maintain optimum sterilization conditions within the chamber.

Claims

1. A method of microbial or chemical decontamination comprising:

exposing an item to be microbially or chemically decontaminated to a multi-component vapor which includes a gaseous oxidant and a second vapor component; and

detecting the gaseous oxidant in the multi-component vapor including;

directing light through the multi-component vapor, the directed light including light of at least a first wavelength range where the gaseous oxidant absorbs but at which the second vapor component does not significantly absorb, the first wavelength range including one or more wavelengths between about 7500 and 8400 nanometers,

detecting the absorbance of light which has passed through the vapor in the first wavelength range, and

determining the concentration of the gaseous oxidant in the multi-component vapor from the detected absorbance.

2. The method of claim 1, wherein the gaseous oxidant includes hydrogen peroxide.

3. The method of claim 1, wherein the second vapor component includes water and the directed light further includes light of a second wavelength range, the second wavelength range being spaced from the first wavelength range, where water absorbs and the gaseous oxidant does not significantly absorb, the step of detecting the absorbance of light further including:

detecting the absorbance of light in the second wavelength range; and

determining the concentration of water in the multi-component vapor from the detected absorbance in the second wavelength range.

5. The method of claim 1, wherein the directed light further includes light of a third wavelength range, the third wavelength range being spaced from the first and second wavelengths, where both the second vapor component and the gaseous oxidant do not significantly absorb, the method further including:

detecting the absorbance of light in the third wavelength range; and

determining a background absorption value from the detected absorbance detecting the absorbance of light in the third wavelength range.

6. The method of claim 1, further including:

in response to the determined concentration of the gaseous oxidant being outside a preselected concentration range, controlling at least one of;

a length of time to which the item is exposed to the vapor;

a pressure of the vapor;

a temperature of the vapor; and

a rate at which the gaseous oxidant is added to the vapor;

to maintain selected decontamination conditions whereby the item is effectively decontaminated.

7. The method of claim 6, further including monitoring at least one of:

the pressure of the vapor;

the temperature of the vapor; and

the relative humidity of the vapor.

8. The method of claim 6, wherein the gaseous oxidant is hydrogen peroxide and the step of controlling the rate at which hydrogen peroxide is added to the vapor includes controlling the rate at which liquid hydrogen peroxide is admitted to a vaporizer which generates the multi-component vapor.

9. The method of claim 8, wherein the step of controlling includes maintaining the concentration of hydrogen peroxide in the vapor below its saturation point, whereby condensation of vapor on the item is minimized.

10. The method of claim 1, further including:

passing a first portion of the light which has passed through the vapor through a first filter which is selective for light in the first wavelength range; and

detecting the absorption of light which has been filtered by the first filter with a first detector.

11. The method of claim 10, further including:

passing a second portion of the light which has passed through the vapor through a second filter which is selective for light in a second wavelength range at which water absorbs, but at which hydrogen peroxide does not significantly absorb; and

detecting the absorption of light which has been filtered by the second filter with a detector.

12. The method of claim 11, where the detector which detects the absorption of light which has been filtered by the second filter is the first detector and the method further includes:

moving the first and second filters such that the first detector sequentially receives light which has passed through the first filter and light which has passed through the second filter.

13. The method of claim 1, wherein the step of detecting includes:

detecting the absorbance of light which has passed through the vapor over a first portion of the first wavelength range when the gaseous oxidant concentration is above a threshold value, and

detecting the absorbance of light which has passed through the vapor over a second portion of the first wavelength range when the gaseous oxidant concentration is below the threshold value, the absorbance of gaseous oxidant in the second portion of the first wavelength range being higher than the absorbance of gaseous oxidant in the first portion of the first wavelength range.

14. The method of claim 13, wherein the gaseous oxidant is hydrogen peroxide and at least one of the following conditions applies:

the first portion of the first wavelength range includes wavelengths of no less than about 8200 nm; and

the first and second portions of the first wavelength range are overlapping.

15. The method of claim 1, wherein the method further includes:

providing a modulated beam of the directed light; and

wherein the step of directing light includes;

directing the modulated beam of light through the multi-component vapor.

16. The method of claim 15, wherein the step of directing the light through the multi-component vapor further includes:

reflecting the light such that it passes back and forth through the multi-component vapor a plurality of times.

4. A method of microbial or chemical decontamination comprising:

exposing an item to be microbially or chemically decontaminated to a multi-component vapor which includes a gaseous oxidant and water; and

detecting the gaseous oxidant and water in the multi-component vapor including;

directing light through the multi-component vapor, the directed light including light of a first wavelength range and a second wavelength range, the first wavelength range being where the gaseous oxidant absorbs but at which water does not significantly absorb, the first wavelength range including one or more wavelengths between about 7500 and 8400 nanometers, the second wavelength range being spaced from the first wavelength range, where water absorbs and the gaseous oxidant does not significantly absorb, the second wavelength range being in the range of from about 5200 nanometers to about 7200 nanometers,

detecting the absorbance of light which has passed through the vapor in the first wavelength range, and

determining the concentration of the gaseous oxidant in the multi-component vapor from the detected absorbance in the first wavelength range,

detecting the absorbance of light in the second wavelength range, and

determining the concentration of water in the multi-component vapor from the detected absorbance in the second wavelength range.

17. A method of microbial or chemical decontamination comprising:

exposing an item to be microbially or chemically decontaminated to a multi-component vapor which includes a gaseous oxidant and a second vapor component;

directing light through a sensor system including a transmitting portion which directs the light through the multi-component vapor and a receiving portion which receives light which has passed through the multi-component vapor, louvers being provided intermediate the transmitting portion and the receiving portion which permit the vapor to pass through the directed light but which inhibit stray radiation from being detected, the directed light including light of at least a first wavelength range where the gaseous oxidant absorbs but at which second vapor component does not significantly absorb, the first wavelength range including one or more wavelengths between about 7500 and 8400 nanometers;

detecting the absorbance of light which has passed through the vapor in the first wavelength range; and

determining the concentration of the gaseous oxidant in the multi-component vapor from the detected absorbance.

18. A method for determining the concentration of hydrogen peroxide and water in a multi-component vapor, the method including:

directing light through the multi-component vapor, the light including wavelengths in a first wavelength range of the mid infrared spectrum at which hydrogen peroxide absorbs but at which water does not significantly absorb and wavelengths in a second wavelength range of the mid infrared spectrum at which water absorbs but at which hydrogen peroxide does not significantly absorb, the mid infrared spectrum being from 2000-10,000 nanometers;

detecting light which has passed through the multi-component vapor in the first wavelength range;

separately detecting light which has passed through the multi-component vapor in the second wavelength range; and

determining concentrations of water and hydrogen peroxide in the multi-component vapor from detected light in the first and second wavelength ranges.

19. A decontamination system comprising:

a chamber which receives items to be microbially decontaminated;

a source of a gaseous sterilant which supplies the gaseous sterilant to the chamber;

a sensor system including;

a transmitting portion which directs light through the gaseous sterilant; and

a receiving portion which receives light which has passed through the gaseous sterilant, the receiving portion including;

a first detector positioned to receive light which has passed through the gaseous sterilant, the first detector detecting light in a wavelength range of the mid-infrared spectrum at which a first component of the gaseous sterilant absorbs, the mid-infrared spectrum being from 2000-10,000 nanometers; and

a control system which controls conditions within the chamber in response to a signal indicative of the light detected by the first detector.

20. The system of claim 19, wherein the receiving portion further includes:

a filter positioned to filter light to be received by the first detector.

21. The system of claim 19, further including:

a second detector which detects light in a second wavelength range spaced from the first wavelength range at which a second component of the sterilant absorbs but at which the first component does not substantially absorb.

22. A decontamination system comprising:

a chamber which receives items to be microbially decontaminated;

a source of a gaseous sterilant which supplies the gaseous sterilant to the chamber, the sterilant including a mixture of water vapor and vapor hydrogen peroxide;

a sensor system including;

a transmitting portion which directs light through the gaseous sterilant; and

a receiving portion which receives light which has passed through the gaseous sterilant, the receiving portion including;

a first detector positioned to receive light which has passed through the gaseous sterilant, the first detector detecting light in a wavelength range of from about 7500 to 8400 nm at which a first component of the gaseous sterilant absorbs,

a second detector positioned to receive light which has passed through the gaseous sterilant, the second detector detecting light in a wavelength range of from about 5200 to 7200 nm at which a second component of the gaseous sterilant absorbs and the first component does not absorb; and

a control system which controls conditions within the chamber in response to a signal indicative of the light detected by the first detector.

23. A decontamination system comprising:

a chamber which receives items to be microbially decontaminated;

a source of a gaseous sterilant which supplies the gaseous sterilant to the chamber;

a sensor system including;

a transmitting portion which directs light through the gaseous sterilant;

a receiving portion which receives light which has passed through the gaseous sterilant, the receiving portion including;

a first detector positioned to receive light which has passed through the gaseous sterilant, the first detector detecting light in a wavelength range of the mid-infrared spectrum at which a first component of the gaseous sterilant absorbs, and

an elongated polygonally cross sectional, apertured tube connected with the transmitting and receiving portions to maintain the transmitting and receiving portions in a fixed relationship; and

a control system which controls conditions within the chamber in response to a signal indicative of the light detected by the first detector.

24. The system of claim 23, wherein the apertured tube includes louvers adjacent the apertures which inhibit stray radiation from entering the receiving portion.

25. The system of claim 23, wherein the detector is displaced from the apertured tube to shield the detector from stray light.