Method and system for the in situ synthesis of a combinatorial library of supported catalyst materials

• US 6,875,717 B2
• Filed: 07/16/2003
• Issued: 04/05/2005
• Est. Priority Date: 03/01/2000
• Status: Expired due to Term

• Current Assignee: Freeslate Inc. (Unchained Labs Inc.)
• Original Assignee: Symyx Technologies Incorporated (Dassault Systemes SA)
• Inventors: Lugmair, Claus G., Hagemeyer, Alfred, Giaquinta, Daniel M., Poojary, Damodara M.
• Primary Examiner(s): Nguyen, Cam N.
• Application Number:
  US10/621,188
• Publication Number:
  US 20040058811A1
• Time in Patent Office: 629 Days
• Field of Search: 502/2, 502/182, 502/183, 502/184, 502/185, 502240-249, 502253-263, 502305-355, 502/439, 502/527.14, 502/527.23, 502/527.24, 502/300
• US Class Current: 502/2
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00315 Microtiter plates
• CPC Class Codes: B01J 2219/00317 Microwell devices, i.e. having large numbers of wells
• CPC Class Codes: B01J 2219/00527 Sheets
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/0059 Sequential processes
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00702 Processes involving means for analysing and characterising the products
• CPC Class Codes: B01J 2219/00745 Inorganic compounds
• CPC Class Codes: B01J 2219/00747 Catalysts
• CPC Class Codes: B01J 23/892 Nickel and noble metals
• CPC Class Codes: B01J 37/0201 Impregnation
• CPC Class Codes: C40B 30/08 by measuring catalytic activity
• CPC Class Codes: C40B 40/18 Libraries containing only inorganic compounds or inorganic materials
• CPC Class Codes: C40B 60/14 for creating libraries

Abstract

A method and system for the in situ synthesis of a combinatorial library including impregnating a first component with a second component. The method and system advantageously may be employed in the synthesis of materials for screening for usefulness as a catalyst.

Claims

1. A method for forming an array of supported catalyst materials, said method comprising the steps of:

a) delivering simultaneously at least four porous catalyst carriers in a dry solid state to at least four regions on a substrate, respectively;

b) impregnating said catalyst carrier with a catalytically active component or a precursor thereof in a liquid medium on said substrate to form an array of supported materials for screening for heterogeneous catalytic properties; and

c) removing at least a portion of said liquid medium.

2. The method according to claim 1 further comprising heat treating said array.

3. The method according to claim 1 further comprising calcining said array.

4. The method according to claim 1 wherein a composition of said catalyst carrier is different at different locations across the substrate.

5. The method according to claim 1 wherein the catalytically active component or the precursor thereof is different at different locations across the substrate.

6. The method according to claim 1 wherein the catalytically active component or the precursor thereof includes at least 3 component materials.

7. The method according to claim 1, further comprising screening said array for hereogeneous catalytic properties while said materials are on said substrate.

8. A method for forming an array of supported catalyst materials, said method comprising the steps of:

a) delivering a plurality of solids, each consisting essentially of a different catalyst carrier, to a different region on a substrate; and

b) impregnating said catalyst carrier with an amount of a catalytically active component or a precursor thereof on said substrate to form an array of supported materials.

9. The method according to claim 8 further comprising heat treating said array.

10. The method according to claim 8 further comprising calcining said array.

11. The method according to claim 8 wherein the at least four porous catalyst carriers are delivered simultaneously.

12. The method according to claim 8 wherein the catalytically active component or the precursor thereof is different at different locations across the substrate.

13. The method according to claim 8 wherein the catalytically active component or to precursor thereof includes at least 3 component materials.

14. A method for forming an array of supported catalyst candidate materials, the method comprising:

a) packing a solid support component into four or more wells of a first substrate, the first substrate having a substantially planar top surface between the tops of the four or more wells;

b) removing excess solid support component from the first substrate by substantially leveling the packed support component in the four or more wells with the top surface of the first substrate;

c) transferring the leveled, packed supports into four or more wells of a second substrate, the spatial arrangement of the four or more wells of the second substrate substantially corresponding to the spatial arrangement of the four or more wells of the first substrate and having a depth that is less than the depth of the corresponding four or more wells of the first substrate, the second substrate having a substantially planar top surface between the tops of the four or more wells;

d) removing excess solid support component from the second substrate by substantially leveling the packed support component in the four or more wells with the top surface of the second substrate;

e) impregnating the four or more supports in situ in the second substrate with a candidate catalyst or a precursor thereof; and

f) drying the impregnated supports to form an array of supported candidate catalyst materials.

15. The method according to claim 14 wherein the drying step includes heat treating said array.

16. The method according to claim 14 wherein the drying step includes calcining said array.

17. The method according to claim 14 wherein the at least four leveled, packed supports are transferred simultaneously.

18. The method according to claim 14 wherein athe composition of said catalyst supports is different at different locations across the substrates.

19. The method according to claim 14 wherein the candidate catalyst or the precursor thereof is different at different locations across the second substrate.

20. The method according to claim 14 wherein the candidate catalyst or the precursor thereof includes at least 3 component materials.