Microfluidic devices with thick-film electrochemical detection
First Claim
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1. An apparatus for conducting a microfluidic process and analysis, said apparatus comprising:
- a first substrate having at least one exterior edge;
at least one elongated separation channel in the first substrate, the separation channel having an inlet end and an outlet end transiting the at least one exterior edge;
a fluidic transport means for transport of fluids through the separation channel;
a second substrate; and
at least one thick-film electrode for analyte detection on the second substrate, the thick-film electrode being in fluidic connection with the outlet end of the separation channel.
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Abstract
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic channel, and at least one thick-film electrode in fluidic connection with the outlet end of the microfluidic channel. The present invention includes an integrated on-chip combination reaction, separation and thick-film electrochemical detection microsystem, for use in detection of a wide range of analytes, and methods for the use thereof.
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Citations
82 Claims
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1. An apparatus for conducting a microfluidic process and analysis, said apparatus comprising:
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a first substrate having at least one exterior edge;
at least one elongated separation channel in the first substrate, the separation channel having an inlet end and an outlet end transiting the at least one exterior edge;
a fluidic transport means for transport of fluids through the separation channel;
a second substrate; and
at least one thick-film electrode for analyte detection on the second substrate, the thick-film electrode being in fluidic connection with the outlet end of the separation channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method for detecting an analyte, comprising the steps of:
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providing a substrate with a microfluidic channel disposed thereon, the microfluidic channel having an inlet end and an outlet end transiting an exterior edge of the first substrate;
introducing the analyte in the inlet end of the microfluidic channel;
transporting the analyte in a fluid solution through the microfluidic channel to the outlet end;
contacting the solution containing the analyte with a thick-film electrode disposed on a second substrate and in fluidic connection with the outlet end of the microfluidic channel;
providing electrical contact to the thick-film electrode; and
analyzing the analyte at the thick-film electrode by electrochemical detection. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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64. An apparatus for conducting a microfluidic process and analysis, said apparatus comprising:
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a first substantially planar substrate having at least one defined edge;
at least one elongated separation channel in the first substrate, the separation channel having an inlet end and an outlet terminating at a defined edge;
a second substrate with at least one thick-film electrode for analyte detection disposed thereon, the second substrate being removably positionable at a non-zero angle with respect to the first substrate and the thick-film electrode being in fluidic connection with the outlet end of the separation channel. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82)
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Specification