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Methods for determining steroid responsiveness

  • US 6,878,518 B2
  • Filed: 01/22/2002
  • Issued: 04/12/2005
  • Est. Priority Date: 01/22/2002
  • Status: Active Grant
First Claim
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1. A method for determining steroid responsiveness in a subject, the method comprising the steps of:

  • (a) determining a first level of expression of RNA from a first gene known or suspected to be steroid responsive in a tissue, body fluid or cell from a subject undergoing steroid treatment;

    (b) determining a second level of expression of RNA from a second gene known or suspected to be non-responsive to steroids in the tissue, body fluid or cell; and

    (c) comparing the first and second levels of RNA to create a ratio;

    (d) determining the steroid responsiveness of the subject based on the ratio, wherein the subject is steroid responsive if the ratio is higher than a predetermined control ratio for untreated or nonresponsive subjects, or similar to prior ratios for the subject when the subject was previously determined to be responsive.

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