Method and apparatus for magnetic resonance arteriography using contrast agents

• US 6,879,853 B2
• Filed: 01/24/2003
• Issued: 04/12/2005
• Est. Priority Date: 10/06/1997
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R., Meaney, James F. M.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US10/350,487
• Publication Number:
  US 20030135111A1
• Time in Patent Office: 809 Days
• Field of Search: 600/410, 600/415, 600/419, 600/420, 324/306, 324/307, 324/309
• US Class Current: 600/420
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/704 Tables
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
• CPC Class Codes: G01R 33/56383 involving motion of the sample as a whole, e.g. multistation MR or MR with continuous table motion

Abstract

The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient'"'"'s body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume. This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Claims

1. A method of imaging arteries in a human patient using a magnetic resonance imaging system and a magnetic resonance contrast agent, wherein the arteries include a first artery which is located in a first image volume, a second artery which is located in a second image volume and a third artery which is located in a third image volume, the method comprising:

injecting the human patient with the magnetic resonance contrast agent via substantially one injection;

collecting magnetic resonance image data of the first image volume, wherein at least a portion of the image data of the first image volume is collected during an arterial phase of contrast enhancement of the first artery and wherein the first artery is in the abdomen or the pelvis of the human patient;

collecting magnetic resonance image data of the second image volume, wherein at least a portion of the image data of the second image volume is collected during an arterial phase of contrast enhancement of the second artery and wherein the second artery is in a leg of the human patient; and

collecting magnetic resonance image data of the third image volume, wherein at least a portion of the image data of the third image volume is collected during an arterial phase of contrast enhancement of the third artery and wherein the third artery is in a foot of the human patient.

2. The method of claim 1 further including constructing an image of the first artery using the image data of the first image volume and an image of the second artery using the image data of the second image volume.

3. The method of claim 2 further including combining the image of the first artery with the image of the second artery in a mosaic manner.

4. The method of claim 1 further including applying a tourniquet to the patient to reduce blood flow in a calf or a thigh of the human patient.

5. The method of claim 1 wherein collecting the magnetic resonance image data of the second image volume includes collecting image data which is representative of the center of k-space substantially at a beginning of a second imaging sequence.

6. The method of claim 1 further including administering the magnetic resonance contrast agent to the patient over a substantial portion of the period of collection of the image data of the first image volume.

7. A method of imaging arteries in a patient using a magnetic resonance imaging system, wherein the arteries include a first artery which is located in a first image volume and a second artery which is located in a second image volume, the method comprising:

injecting a magnetic resonance contrast agent of substantially one injection into the patient, wherein the magnetic resonance contrast agent is injected using,

a coiled conduit having a first end, a second end and an inner diameter;

a multiport adapter connected to the first end of the coiled conduit, the multiport adapter having at least two input ports wherein each input port includes a one way valve; and

a locking mechanism coupled to the second end of the coiled conduit wherein the locking mechanism is capable of securing the coiled conduit to a catheter in the patient;

collecting magnetic resonance image data of the first image volume, wherein a substantially portion of the magnetic resonance image data of the first image volume is collected during an arterial phase of contrast enhancement of the first artery;

positioning the patient in a second location to define a second field of view which encompasses the second artery wherein the second artery is a femoral artery, a popliteal artery or a tibial artery of the patient; and

collecting magnetic resonance image data of the second image volume, wherein a substantially portion of the magnetic resonance image data of the second image volume is collected during an arterial phase of contrast enhancement of the second artery.

8. The method of claim 7 further including constructing an image of the first artery using the magnetic resonance image data of the first image volume and an image of the second artery using the magnetic resonance image data of the second image volume.

9. The method of claim 8 further including combining the image of the first artery with the image of the second artery in a mosaic manner.

10. The method of claim 7 wherein collecting the magnetic resonance image data of the first image volume includes collecting image data which is representative of the center of k-space substantially at a beginning of a first imaging sequence.

11. The method of claim 7 wherein collecting the magnetic resonance image data of the second image volume includes collecting image data which is representative of the center of k-space substantially at a beginning of a second imaging sequence.

12. The method of claim 7 further including applying a tourniquet to the patient to reduce blood flow in a calf or a thigh of the patient.

13. A magnetic resonance imaging system for imaging arteries in a patient using an injected contrast agent of substantially one injection, wherein the arteries include a first artery which is located in a first image volume and a second artery which is located in a second image volume, the system comprises:

an injection apparatus including,

a coiled conduit having a first end, a second end and an inner diameter;

a multiport adapter connected to the first end of the coiled conduit, the multiport adapter having at least two input ports wherein each input port includes a one way valve; and

a locking mechanism coupled to the second end of the coiled conduit wherein the locking mechanism is capable of securing the coiled conduit to a catheter;

a platform to support the patient, the platform being moveable between a plurality of locations including a first location which defines a first field of view encompassing the first artery and a second location which defines a second field of view encompassing the second artery, wherein the first field of view and the second field of view are 48 cm or less; and

magnetic resonance imaging unit to collect magnetic resonance image data of the first image volume during an arterial phase of contrast enhancement of the first artery and while the platform is positioned at the first location, and to collect magnetic resonance image data of the second image volume during an arterial phase of contrast enhancement of the second artery and while the platform is positioned at the second location.

14. The system of claim 13 wherein the magnetic resonance imaging unit constructs an image of the first artery using the magnetic resonance image data of the first image volume and an image of the second artery using the magnetic resonance image data of the second image volume.

15. The system of claim 13 wherein the coiled conduit is substantially transparent.

16. The system of claim 13 wherein the coiled conduit is flexible and is comprised of a plastic material having a hardness and wall thickness sufficient to prevent kinking.

17. The system of claim 13 wherein the multiport adapter includes a first input port and second input port, wherein the first input port is adapted to receive a syringe containing a magnetic resonance contrast agent and the second input port is adapted to receive a syringe containing a flush solution.

18. The system of claim 17 wherein the first input port extends in a first direction and the second input ports extends in a second direction such that an angle formed by the first and second input ports is greater than about 10 degrees and less than about 45 degrees.

19. The system of claim 18 wherein the wherein the angle formed by the first and second input ports is greater than about 30 degrees and less than about 40 degrees.

20. The system of claim 18 wherein the multiport adapter is a two port “

Y”

bifurcate.

21. The system of claim 13 wherein the inner diameter of the conduit is greater than about 0.04 inches and less than about 0.12 inches.

22. The system of claim 13 wherein the inner diameter of the conduit is greater than about 0.06 inches and less than about 0.10 inches.

23. The system of claim 13 wherein the inner diameter of the conduit is sufficiently large to provide minimum resistance to fluid flow and sufficiently small to provide minimum dead space.

24. The system of claim 13 wherein the thickness of the conduit is greater than about 0.02 inches and less than about 0.08 inches.

25. The system of claim 13 wherein the locking mechanism is a male luer locking mechanism having a male luer protector and a male luer swivel.

26. The system of claim 13 wherein the coiled conduit may be extended longer than 3 meters.

27. The system of claim 13 Wherein the coiled conduit has a hardness of about 80 on the Shore A Hardness scale.

28. The system of claim 13 wherein the magnetic resonance imaging unit collects the center of k-space of the second image volume substantially at a beginning of a first imaging sequence.

29. The system of claim 13 wherein the magnetic resonance imaging unit collects the center of k-space of the first image volume substantially in a middle of a first imaging sequence.

30. The system of claim 29 wherein the magnetic resonance imaging unit collects the center of k-space of the second image volume substantially in the middle of a second imaging sequence.