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Compositions and methods for promoting nerve regeneration

  • US 6,881,409 B2
  • Filed: 09/04/2003
  • Issued: 04/19/2005
  • Est. Priority Date: 10/24/1997
  • Status: Expired due to Fees
First Claim
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1. A method of improving nerve growth into a partial transection of a spinal cord, comprising:

  • introducing into the transection NGF and a non-cellular gap filling agent that includes a therapeutically effective amount of a benzoquinone ansamycin that binds to a polypeptide component of a steroid receptor complex other than a steroid binding portion of the complex, wherein the NGF and benzoquinone ansamycin are present in a therapeutically sufficient amount to interfere with association or promote dissociation of hsp90 from the complex, and promote nerve growth into the spinal cord.

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