Subcutaneous glucose electrode
First Claim
1. An electrode comprising:
- a non-corroding, conducting base electrode;
a multilayered polymeric composition disposed on the base electrode, the composition comprising;
a sensing layer adjacent to and contacting the base electrode, the sensing layer comprising a redox enzyme crosslinked to a redox polymer;
an analyte diffusion limiting layer disposed on the sensing layer; and
a biocompatible polymer layer disposed on the analyte diffusion limiting barrier layer.
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Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
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Citations
20 Claims
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1. An electrode comprising:
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a non-corroding, conducting base electrode;
a multilayered polymeric composition disposed on the base electrode, the composition comprising;
a sensing layer adjacent to and contacting the base electrode, the sensing layer comprising a redox enzyme crosslinked to a redox polymer;
an analyte diffusion limiting layer disposed on the sensing layer; and
a biocompatible polymer layer disposed on the analyte diffusion limiting barrier layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An electrode comprising:
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a non-corroding metal or carbon base electrode;
a non-leachable sensing layer coupled to the base electrode;
a glucose flux-limiting layer coupled to the sensing layer; and
a biocompatible layer bound to the glucose flux-limiting layer. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification