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Multifunctional polymeric surface coatings in analytic and sensor devices

  • US 6,884,628 B2
  • Filed: 04/28/2000
  • Issued: 04/26/2005
  • Est. Priority Date: 04/28/1999
  • Status: Expired due to Term
First Claim
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1. A method for reducing non-specific adsorption of inorganic ions, peptides, proteins, and saccharides to a surface of a device comprisingapplying to or coating onto a surface of an analytical or sensing device, wherein the surface comprises a material selected from the group consisting of metals, metal oxides, and charged polymers. a non-interactive polyionic multifunctional copolymer, wherein the non-interactive polyionic multifunctional copolymer comprises non-interactive polymer sidechains covalently grafted onto a charged polyionic polymeric backbone which has an anionic charge at a pH greater than 4, wherein the polyionic polymeric backbone interacts with the surface at a pH greater than 4, where some or all of the non-interactive polymer sidechains are partially or fully functionalized at or near the free terminal position of the non-interactive polymer sidechains with a functional molecule.

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