Endoprostheses and methods of manufacture

• US 6,887,266 B2
• Filed: 01/15/2003
• Issued: 05/03/2005
• Est. Priority Date: 11/14/2002
• Status: Expired due to Fees

• Current Assignee: Synecor LLC
• Original Assignee: Synecor LLC
• Inventors: Williams, Michael S., Glenn, Richard A., Smith, Jeffrey A., DeSimone, Joseph M., Holbrook, Kevin D.
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): Sweet, Thomas
• Application Number:
  US10/342,622
• Publication Number:
  US 20040098100A1
• Time in Patent Office: 839 Days
• Field of Search: 623/1.16
• US Class Current: 623/1.16
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/825 having longitudinal struts
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2250/0014 having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Improved endoprostheses comprising a delivery configuration and a deployed configuration and methods of manufacture are disclosed. Some embodiments according to the invention comprise woven tubular structures and means for maintaining said structures in their expanded configurations. In one embodiment of the invention, locking elements disposed on one or more fibers maintain said endoprosthesis in its deployed configuration. In alternative embodiments, one or more axial members may maintain said endoprosthesis in its deployed configuration. In yet additional alternative embodiments, a chemical bond or thermocouple may maintain said endoprosthesis in its deployed configuration. Some embodiments according to the invention may comprise erodible material.

Claims

1. An endoprosthesis comprising one or more fibers, said one or more fibers comprising a braid comprising one or more points of intersection, said endoprosthesis further defining a generally tubular structure, a delivery configuration and a deployed configuration, and said one or more fibers comprising one or more locking elements proximate said one or more points of intersection, wherein said one or more locking elements engage upon deployment to maintain said endoprosthesis in said deployed configuration, without requiring an additional locking member or axial element.

2. The endoprosthesis according to claim 1 wherein said endoprosthesis comprises one or more erodible materials.

3. The endoprosthesis of claim 1 wherein said one or more locking elements comprise locking protrusions.

4. The endoprosthesis of claim 1 wherein said one or more locking elements comprise one or more notches.

5. The endoprosthesis of claim 1 wherein said one or more locking elements comprise male and female elements.

6. The endoprosthesis of claim 1 wherein said one or more fibers comprises a chemical bond at said one or more points of intersection when said endoprosthesis is in said deployed configuration.

7. The endoprosthesis of claim 1 wherein said one or more locking elements comprise one or more thermocoupling element.

8. The endoprosthesis of claim 1 wherein said endoprosthesis comprises a therapeutic agent incorporated into or upon said endoprosthesis utilizing a solvent in a supercritical state.

9. The endoprosthesis of claim 1 wherein said one or more fibers comprises one or more curable materials.

10. The endoprosthesis according to claim 1 wherein said endoprosthesis further comprises a therapeutic agent incorporated into or disposed upon said endoprosthesis.

11. A method of treatment of a stenosis of a body lumen comprising the steps of:

providing a generally tubular endoprosthesis comprising a delivery configuration and a deployed configuration and formed from one or more fibers comprising one or more locking elements and one or more points of intersection between said one or more fibers, whereby said locking elements engage said fibers proximate said one or more points of intersection in order to maintain said endoprosthesis in said deployed configuration without requiring an additional locking member or axial element;

placing said endprosthesis in a body lumen;

deploying said endoprosthesis, thereby engaging said locking elements.

12. The method of claim 11 wherein said locking elements comprise one or more thermocoupling element, and wherein the method further comprises the step of heating one or more of said thermocoupling element, thereby engaging said thermocoupling element.

15. The method according to claim 11 wherein said endoprosthesis further comprises a therapeutic agent incorporated into or disposed upon said endoprosthesis.

13. A woven erodible endoprosthesis capable of withstanding 300 mm Hg pressure radially within a body lumen, said endoprosthesis comprising a delivery configuration and a deployment configuration, said endoprosthesis comprising means for locking said endoprosthesis in said deployment configuration.

14. The endoprosthesis of claim 13 wherein said means for locking said endoprosthesis in said deployment configuration comprises a directional locking engagement mechanism, said mechanism requiring less than 0.25 pound of force to engage and greater than 1.0 pound force to disengage.

16. An endoprosthesis comprising one or more fibers comprising one or more points of intersection, said endoprosthesis defining a generally tubular structure, a delivery configuration and a deployed configuration, said endoprosthesis further comprising means for maintaining said endoprosthesis in said deployed configuration, wherein said means for maintaining said endoprosthesis in said deployed configuration comprises a chemical bond at said one or more points of intersection when said endoprosthesis is in said deployed configuration.

17. The endoprosthesis according to claim 16 wherein said endoprosthesis further comprises a therapeutic agent incorporated into or disposed upon said endoprosthesis.

18. An endoprosthesis comprising one or more fibers comprising one or more points of intersection, said endoprosthesis defining a generally tubular structure, a delivery configuration and a deployed configuration, said endoprosthesis further comprising means for maintaining said endoprosthesis in said deployed configuration, wherein said means for maintaining said endoprosthesis in said deployed configuration comprises one or more thermocoupling element.

19. The endoprosthesis according to claim 18 wherein said endoprosthesis further comprises a therapeutic agent incorporated into or disposed upon said endoprosthesis.

20. An endoprosthesis comprising one or more fibers defining a generally tubular structure, said endoprosthesis comprising a delivery configuration and a deployed configuration, said endoprosthesis further comprising means for maintaining said endoprosthesis in said deployed configuration, and wherein said endoprosthesis comprises a therapeutic agent incorporated into or upon said endoprosthesis utilizing a solvent in a supercritical state.

21. A method of treatment of a stenosis of a body lumen comprising the steps of:

providing a generally tubular endoprosthesis comprising a delivery configuration and a deployed configuration and formed from one or more fibers comprising one or more locking elements and one or more points of intersection between said one or more fibers, said locking elements comprising one or more thermocouples, whereby said locking elements engage said fibers when said endoprosthesis is in said deployed configuration;

placing said endoprosthesis in a body lumen;

deploying said endoprosthesis;

heating said one or more of said thermocoupling element, thereby engaging said thermocoupling element.

22. The method according to claim 21 wherein said endoprosthesis further comprises a therapeutic agent incorporated into or disposed upon said endoprosthesis.

23. A woven erodible endoprosthesis capable of withstanding 300 mm Hg pressure radially within a body lumen, said endoprosthesis comprising a delivery configuration and a deployment configuration and comprising means for locking said endoprosthesis in said deployment configuration, wherein said means for locking said endoprosthesis in said deployment configuration comprises a directional locking engagement mechanism, said mechanism requiring less than 0.25 pound of force to engage and exhibiting greater than 1.0 pound force to disengage.

24. The endoprosthesis according to claim 23 wherein said endoprosthesis further comprises a therapeutic agent incorporated into or disposed upon said endoprosthesis.