Calcium glutarate supplement and phosphorus binder
First Claim
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1. A method of inhibiting gastrointestinal absorption of phosphorous in a person, comprising:
- orally administering to a person in need thereof a quantity of a pharmaceutical composition of calcium glutarate sufficient to bind with phosphorous in the gastrointestinal tract, wherein said pharmaceutical composition inhibits gastrointestinal absorption of phosphorous in the person, and wherein said composition does not contain non-glutarate calcium salts in amounts sufficient to neutralize gastric acidity.
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Abstract
Methods of controlling calcium intake and phosphate metabolism and metabolic acidosis in patients suffering from renal failure and associated hyperphosphatemia or patients predisposed to development of a hyperphosphatemic condition are provided. The method in accordance with this invention comprises administering to a patient a calcium glutarate compound. Therapeutic benefit can be realized in accordance with such method by administering the compound orally to a patient to increase available calcium and contact and bind with ingested phosphate in the patient'"'"'s digestive tract, and thereby prevent its intestinal absorption.
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Citations
26 Claims
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1. A method of inhibiting gastrointestinal absorption of phosphorous in a person, comprising:
- orally administering to a person in need thereof a quantity of a pharmaceutical composition of calcium glutarate sufficient to bind with phosphorous in the gastrointestinal tract, wherein said pharmaceutical composition inhibits gastrointestinal absorption of phosphorous in the person, and wherein said composition does not contain non-glutarate calcium salts in amounts sufficient to neutralize gastric acidity.
- View Dependent Claims (2, 3, 4, 5)
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6. A method of inhibiting gastrointestinal absorption of phosphorous in an individual, comprising:
- orally administering to a person in need thereof a quantity of a pharmaceutical composition of calcium glutarate sufficient to bind with phosphorous in the gastrointestinal tract at a mealtime, wherein said pharmaceutical composition inhibits gastrointestinal absorption of phosphorous in the person, and wherein said composition does not contain non-glutarate calcium salts in amounts sufficient to neutralize gastric acidity.
- View Dependent Claims (7, 8, 9, 10)
- 11. A pharmaceutical therapeutic composition in solid or gel oral dosage form for controlling phosphate retention in patients having need for reduced absorption of dietary phosphate, said oral dosage form composition comprising sufficient calcium glutarate to bind with phosphorous in the gastrointestinal tract, and a pharmaceutically acceptable excipient for said oral dosage form, wherein said solid or gel oral dosage form comprises a single dose, and wherein said composition does not contain non-glutarate calcium salts in amounts sufficient to neutralize gastric acidity.
- 15. An orally administerable pharmaceutical composition for use in the treatment of hyperphosphatemia and for reducinig the risk of the formation of phosphate- and oxalate-containing kidney stones in humans which comprises as the principal active ingredient a therapeutically effective amount of calcium glutarate sufficient to bind with phosphorous in the gastrointestinal tract combined with a pharmaceutically acceptable carrier, wherein said pharmaceutical composition comprises, solid or gel oral dosage of a single dose, and wherein said composition does not contain non-ghitarate calcium salts in amounts sufficient to neutralize gastric acidity.
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21. A pharmaceutical compound for treating hyperphosphatemia and for reducing the risk of the formation of phosphate-containing kidney stones in humans of the formula:
- pharmaceutical grade [OOC—
CH2—
CH2—
CH2—
COO]Ca in an amount sufficient to inhibit gastrointestinal absorption of phosphorous in a person, and a pharmaceutically acceptable carrier, wherein said pharmaceutical composition comprises a solid or gel oral dosage of a single dose, and wherein said composition does not contain non-glutarate calcium salts in amounts sufficient to neutralize gastric acidity. - View Dependent Claims (22, 23, 24, 25, 26)
- pharmaceutical grade [OOC—
Specification