Modular systems and methods for using sample processing devices

• US 6,889,468 B2
• Filed: 12/28/2001
• Issued: 05/10/2005
• Est. Priority Date: 12/28/2001
• Status: Active Grant

• Current Assignee: Diasorin Italia SPA
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Aysta, James E., Bedingham, William, Robole, Barry W.
• Primary Examiner(s): Soderquist, Arlen
• Application Number:
  US10/034,993
• Publication Number:
  US 20030124506A1
• Time in Patent Office: 1,229 Days
• Field of Search: 422/64, 422/67, 422/72, 436/45, 219/388, 219/432, 219428-429, 219/435
• US Class Current: 436/45
• CPC Class Codes: B01L 2300/0803 Disc shape
• CPC Class Codes: B01L 2300/1861 using radiation
• CPC Class Codes: B01L 3/50851 specially adapted for heating or cooling samples laboratory heating apparatus B01L7/00; incubators C12M
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: B01L 7/54 using spatial temperature gradients
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: G01N 2035/00326 Analysers with modular structure
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor

Abstract

Sample processing systems and methods of using those systems for processing sample materials located in devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include connection apparatus that allow for rapid and easy removal and/or replacement of base plates.

Claims

1. A method of adapting a sample processing system for use with a selected sample processing device, the method comprising:

providing a sample processing system that comprises;

a base plate adapted to receive a sample processing device, the base plate comprising a thermal structure, an electrically powered device, and a photovoltaic cell;

a drive system adapted to rotate the base plate about an axis of rotation;

a system controller; and

connection apparatus located between the base plate and the drive system, the connection apparatus releasably attaching the base plate to the drive system for rotation of the base plate about the axis of rotation, wherein the connection apparatus comprises;

a drive side connector fixedly attached to the drive system;

a plate side connector fixedly attached to the base plate;

operably attaching the base plate to the drive system by mating the drive side connector with the plate side connector;

providing electrical power to the electrically powered device from the photovoltaic cell; and

rotating the base plate about the axis of rotation using the drive system.

2. A method according to claim 1, further comprising identifying the base plate to the system controller.

3. A method according to claim 2, wherein identifying the base plate to the system controller comprises optically sensing indicia on the base plate.

4. A method according to claim 2, wherein the identifying comprises transmitting a base plate identity through the connection apparatus.

5. A method according to claim 4, wherein transmitting a base plate identity through the connection apparatus comprises electrically transmitting the base plate identity through electrical connectors on the drive side connector and the plate side connector.

6. A method according to claim 4, wherein transmitting a base plate identity through the connection apparatus comprises mechanically transmitting the base plate identity through mating mechanical structures on the drive side connector and the plate side connector.

7. A method according to claim 4, wherein transmitting a base plate identity through the connection apparatus comprises optically transmitting the base plate identity through optical transmission structures on the drive side connector and the plate side connector.

8. A method according to claim 1, wherein the method further comprises providing electrical power to the electrically powered device through the drive side connector and the plate side connector of the connection apparatus.

9. A method according to claim 8, wherein providing electrical power to the electrically powered device through the connection apparatus comprises control over delivery of the electrical power by the system controller.

10. A method according to claim 1, wherein the electrically powered device comprises a thermoelectric module in thermal communication with the thermal structure on the base plate.

11. A method according to claim 1, wherein the electrically powered device comprises an electrical resistance beater in thermal communication with the thermal structure on the base plate.

12. A method according to claim 1, wherein the electrically powered device comprises a temperature sensor.

13. A method according to claim 1, wherein the electrically powered device comprises a base plate microprocessor.

14. A method according to claim 13, wherein the base plate further comprises a temperature sensor, and wherein the method comprises:

providing a signal to the base plate microprocessor from the temperature sensor; and

processing the signal from the temperature sensor using the base plate microprocessor.

15. A method according to claim 14, wherein the base plate microprocessor provides a processed signal to the system controller based on the signal received by the base plate microprocessor from the temperature sensor.

16. A method according to claim 15, wherein the processed signal passes through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

17. A method according to claim 1, wherein the base plate further comprises a temperature sensor in thermal communication with the thermal structure, and wherein the method further comprises providing a signal from the temperature sensor to the system controller.

18. A method according to claim 17, wherein providing a signal from the temperature sensor to the system controller comprises passing the signal through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

19. A method according to claim 1, wherein the base plate further comprises a base plate microprocessor, and wherein the method comprises:

providing electrical energy to the base plate microprocessor from the photovoltaic cell;

providing a signal to the base plate microprocessor from the temperature sensor; and

processing the signal from the temperature sensor using the base plate microprocessor.

20. A method according to claim 19, wherein the base plate microprocessor provides a processed signal to the system controller based on the signal received by the base plate microprocessor from the temperature sensor.

21. A method according to claim 19, wherein the processed signal passes through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

22. A method of adapting a sample processing system for use with a selected sample processing device, the method comprising:

providing a sample processing system that comprises;

a base plate adapted to receive a sample processing device, the base plate comprising a thermal structure, an electrically powered device, and a generator coil operatively attached to the base plate;

a drive system adapted to rotate the base plate about an axis of rotation;

a system controller; and

rotating the base plate about the axis of rotation using the drive system; and

providing a magnetic field proximate the base plate such that the generator coil passes through the magnetic field while the base plate is rotating to generate electricity that powers the electrically powered device on the base plate.

23. A method according to claim 22, further comprising identifying the base plate to the system controller.

24. A method according to claim 22, wherein the electrically powered device comprises a thermoelectric module in thermal communication with the thermal structure on the base plate.

25. A method according to claim 22, wherein the electrically powered device comprises an electrical resistance heater in thermal communication with the thermal structure on the base plate.

26. A method according to claim 22, wherein the electrically powered device comprises a temperature sensor.

27. A method according to claim 22, wherein the electrically powered device comprises a base plate microprocessor.

28. A method according to claim 27, wherein the base plate further comprises a temperature sensor, and wherein the method comprises:

providing a signal to the base plate microprocessor from the temperature sensor; and

processing the signal from the temperature sensor using the base plate microprocessor.

29. A method according to claim 28, wherein the base plate microprocessor provides a processed signal to the system controller based on the signal received by the base plate microprocessor from the temperature sensor.

30. A method according to claim 22, wherein the base plate further comprises a temperature sensor in thermal communication with the thermal structure, and wherein the method further comprises providing a signal from the temperature sensor to the system controller.

31. A sample processing system comprising:

a base plate adapted to receive a sample processing device on a top surface of the base plate, the base plate comprising a thermal structure exposed on the top surface of the base plate, an electrically powered device, and a photovoltaic cell operably connected to supply electric energy to the electrically powered device;

a drive system adapted to rotate the base plate about an axis of rotation;

a system controller; and

connection apparatus located between the base plate and the drive system, the connection apparatus releasably attaching the base plate to the drive system for rotation of the base plate about the axis of rotation, wherein the connection apparatus comprises a drive side connector fixedly attached to the drive system and a plate side connector fixedly attached to the base plate;

wherein the plate side connector releasably mates with the drive side connector to operably attach the base plate to the drive system, whereby the drive system is capable of rotating the base plate about the axis of rotation.

32. A method according cc claim 31, further comprising identification indicia identifying a characteristic of the base plate.

33. A method according to claim 32, wherein the identification indicia is optically readable.

34. A method according to claim 32, wherein the identification indicia comprises mating mechanical structures on the drive side connector and the plate side connector.

35. A method according to claim 31, wherein the connection apparatus comprises electrical connectors on the drive side connector and the plate side connector, whereby electrical signals pass between the base plate and the system controller through the electrical connectors.

36. A method according to claim 31, wherein the drive side connector and the plate side connector comprise electrical power transmission structures in electrical communication with the electrically powered device.

37. A method according to claim 31, wherein the electrically powered device comprises a thermoelectric module in thermal communication with the thermal structure on the base plate.

38. A method according to claim 31, wherein the electrically powered device comprises an electrical resistance heater in thermal communication with the thermal structure on the base plate.

39. A method according to claim 31, wherein the electrically powered device comprises a temperature sensor.

40. A method according to claim 31, wherein the electrically powered device comprises a base plate microprocessor in communication with the electrically powered device and the system controller.

41. A method according to claim 40, wherein the base plate microprocessor is in communication with the system controller through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

42. A method according to claim 40, wherein the base plate further comprises a temperature sensor in thermal communication with the thermal structure, and wherein the temperature sensor is in communication with the system controller.

43. A method according to claim 42, wherein the temperature sensor is in communication with the system controller through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

44. A method according to claim 31, further comprising an electromagnetic energy source arranged to direct electromagnetic energy towards a bottom surface of the base plate.

45. A method according to claim 31, further comprising an electromagnetic energy source arranged to direct electromagnetic energy towards the top surface of the base plate.

46. A method according to claim 31, further comprising a plurality of thermoelectric modules in thermal communication with the thermal structure.

47. A sample processing system comprising:

a base plate adapted to receive a sample processing device on a top surface of the base plate, the base plate comprising a thermal structure, an electrically powered device, and a generator coil operatively attached to the base plate;

a drive system adapted to rotate the base plate about an axis of rotation;

a system controller;

connection apparatus located between the base plate and the drive system, the connection apparatus releasably attaching the base plate to the drive system for rotation of the base plate about the axis of rotation;

a magnetic field proximate the base plate, wherein the generator coil operatively attached to the base plate passes through the magnetic field when rotating the base plate about the axis of rotation using the drive system, and wherein the generator coil is operatively connected to the electrically powered device such that the generated electricity powers the electrically powered device on the base plate.

48. A system according to claim 47, wherein the connection apparatus comprises electrical connectors on the drive side connector and the plate side connector, whereby electrical signals pass between the base plate and the system controller through the electrical connectors.

49. A system according to claim 47, wherein the electrically powered device comprises a thermoelectric module in thermal communication with the thermal structure on the base plate.

50. A system according to claim 47, wherein the electrically powered device comprises an electrical resistance beater in thermal communication with the thermal structure on the base plate.

51. A system according to claim 47, wherein the electrically powered device comprises a temperature sensor.

52. A system according to claim 47, wherein the electrically powered device comprises a base plate microprocessor in communication with the electrically powered device and the system controller.

53. A system according to claim 52, wherein the base plate microprocessor is in communication with the system controller through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

54. A method of adapting a sample processing system for use with a selected sample processing device, the method comprising:

providing a sample processing system that comprises;

a base plate adapted to receive a sample processing device, the base plate comprising a thermal structure, an electrically powered device, and a coil operatively attached to the base plate;

a drive system adapted to rotate the base plate about an axis of rotation;

a system controller; and

connection apparatus located between the base plate and the drive system, the connection apparatus releasably attaching the base plate to the drive system for rotation of the base plate about the axis of rotation, wherein the connection apparatus comprises;

a drive side connector fixedly attached to the drive system;

a plate side connector fixedly attached to the base plate;

operably attaching the base plate to the drive system by mating the drive side connector with the plate side connector;

generating electrical power to the electrically powered device by rotating the coil through a magnetic field; and

rotating the base plate about the axis of rotation using the drive system.

55. A method according to claim 54, farther comprising identifying the base plate to the system controller.

56. A method according to claim 55, wherein identifying the base plate to the system controller comprises optically sensing indicia on the base plate.

57. A method according to claim 55, wherein the identifying comprises transmitting a base plate identity through the connection apparatus.

58. A method according to claim 57, wherein transmitting a base plate identity through the connection apparatus comprises electrically transmitting the base plate identity through electrical connectors on the drive side connector and the plate side connector.

59. A method according to claim 57, wherein transmitting a base plate identity through the connection apparatus comprises mechanically transmitting the base plate identity through mating mechanical structures on the drive side connector and the plate side connector.

60. A method according to claim 57, wherein transmitting a base plate identity through the connection apparatus comprises optically transmitting the base plate identity through optical transmission structures on the drive side connector and the plate side connector.

61. A method according to claim 54, wherein the method further comprises providing electrical power to the electrically powered device through the drive aide connector and the plate side connector of the connection apparatus.

62. A method according to claim 61, wherein providing electrical power to the electrically powered device through the drive side connector and the plate side connector of the connection apparatus comprises control over delivery of the electrical power by the system controller.

63. A method according to claim 54, wherein the electrically powered device comprises a thermoelectric module in thermal communication with the thermal structure on the base plate.

64. A method according to claim 54, wherein the electrically powered device comprises an electrical resistance beater in thermal communication with the thermal structure on the base plate.

65. A method according to claim 54, wherein the electrically powered device comprises a temperature sensor.

66. A method according to claim 54, wherein the electrically powered device comprises a base plate microprocessor.

67. A method according to claim 66, wherein the base plate further comprises a temperature sensor, and wherein the method comprises:

providing a signal to the base plate microprocessor from the temperature sensor; and

processing the signal from the temperature sensor using the base plate microprocessor.

68. A method according to claim 67, wherein the base plate microprocessor provides a processed signal to the system controller based on the signal received by the base plate microprocessor from the temperature sensor.

69. A method according to claim 68, wherein the processed signal passes through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

70. A method according to claim 54, wherein the base plate further comprises a temperature sensor in thermal communication with the thermal structure, and wherein the method further comprises providing a signal from the temperature sensor to the system controller.

71. A method according to claim 70, wherein providing a signal from the temperature sensor to the system controller comprises passing the signal through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.

72. A method according to claim 54, wherein the base plate further comprises a base plate microprocessor, and wherein the method comprises:

providing electrical energy to the base plate microprocessor from the photovoltaic cell;

providing a signal to the base plate microprocessor from the temperature sensor; and

processing the signal from the temperature sensor using the base plate microprocessor.

73. A method according to claim 72, wherein the base plate microprocessor provides a processed signal to system controller based on the signal received by the base plate microprocessor from temperature sensor.

74. A method according to claim 72, wherein the processed signal passes through electrical connectors in the drive side connector and the plate side connector of the connection apparatus.