Device for diagnosing physiological state and device for controlling the same

• US 6,890,304 B1
• Filed: 06/02/2000
• Issued: 05/10/2005
• Est. Priority Date: 05/12/1995
• Status: Expired due to Term

• Current Assignee: Seiko Epson Corporation (Seiko Group)
• Original Assignee: Seiko Epson Corporation (Seiko Group)
• Inventors: Uebaba, Kazuo, Amano, Kazuhiko, Ishiyama, Hitoshi
• Primary Examiner(s): NASSER, ROBERT L
• Application Number:
  US09/587,049
• Time in Patent Office: 1,803 Days
• Field of Search: 600/485, 600500-503, 600300-301, 600/490, 600493-496, 600/455, 600453- 6, 600544- 5, 604 65- 67
• US Class Current: 600/500
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/18 for vehicle drivers or machine operators
• CPC Class Codes: A61B 5/4854 Diagnosis based on concepts of traditional oriental medicine
• CPC Class Codes: A61B 5/6806 Gloves
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/6822 Neck
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The present invention relates to a device for diagnosing physiological state based on blood pulse waves detected in the body. It is the objective of the present invention to provide a device which correctly diagnoses the current physiological state based on changes in physiological state measured over a specified period of time in the past while taking into consideration the cyclical variation exhibited in physiological state. In order to realize this objective, the device according to the present invention has as its main components: blood pulse wave detector 381 and stroke-volume-per-beat measurer 382 which respectively detect blood pulse wave and stroke volume in the body; blood pulse wave extraction memory 386 which extracts characteristic information from the detected blood pulse wave; memory 383 in which the physiological state calculated from the stroke volume and this characteristic information is stored; output portion 385 which outputs an alarm; and microcomputer 387 which controls each part inside the device. The microcomputer calculates the circulatory parameters based on characteristic information obtained from the waveform extraction memory, and stores the parameters in memory at specified time intervals. At these times, microcomputer 387 calculates the circulatory parameters from the stroke volume per beat and the characteristic information of the blood pulse wave at specified time intervals, and stores the parameters in memory 383. Further, microcomputer 387 reads out from memory 383 the circulatory parameters from a specified time interval in the past, and calculates the average value and standard deviation. Microcomputer 387 then determines whether or not the current circulatory parameters are within a specified range determined by their average value and standard deviation. When the circulatory parameters are determined to be outside this range, microcomputer 387 controls output portion 385 to sound an alarm.

Claims

1. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state related to arousal or sedation in a patient and a blood pulse waveform in the patient;

an administering means for administering a drug to the patient;

a recording means for recording blood pulse waveforms corresponding to a physiological state in which drug administration is necessary; and

a drug administration control means for comparing the blood pulse waveform measured by the measuring means and the blood pulse waveforms stored in the recording means, and for issuing a command to carry out administration of a drug based on the result of the comparison.

2. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state related to arousal or sedation in a patient;

an administering means for administering a drug to the patient;

a drug administration control means for issuing a command to the administering means for drug administration when the indicator of the physiological state satisfies specific conditions; and

a means for detecting the output of a drug administration command, for determining from the point of this detection whether or not the indicator of physiological state has reached a state which does not satisfy the specified conditions, and for providing notification when the indicator of the physiological state has reached a state which does not satisfy the specified conditions.

3. A device for controlling a physiological state according to claim 2, wherein the administering means comprises an infuser of the drug.

4. A device for controlling a physiological state according to claim 2, wherein the administering means comprises an emission of the drug.

5. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state related to arousal or sedation in a patient;

an administering means for administering a drug to the patient;

a blood pulse detector for detecting a blood pulse cycle of blood sent from the patient'"'"'s heart; and

a drug administration control means for issuing a command to the administering means for drag administration when the indicator of the physiological state satisfied specific conditions,

wherein the drug administration control means issues a command to administer a drug to the administering means during the time interval from one blood pulse beat to the next blood pulse beat in synchronization with the blood pulse cycle.

6. A device for controlling a physiological state according to claim 5, wherein the administering means comprises an infuser of the drug.

7. A device for controlling a physiological state according to claim 5, wherein the administering means comprises an emission of the drug.

8. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state;

a recording means for storing the indicator measured, up until a current point in time;

a control means for selecting a time period in which the indicator is changing according to a specified trend, and for outputting a command to administer a drug during the time period; and

an administering means for administering the drug in accordance with the command; and

wherein the control means selects a time period in which the indicator is changing according to a specified trend, and outputs a command to administer a drug during the time period.

9. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state;

a recording means for storing the indicator measured, up until a current point in time;

a control means for selecting a time period in which the indicator is changing according to a specified trend, and for outputting a command to administer a drug when the trend of the change differs from a trend demonstrated by the indicator during a past time period; and

an administering means for administering a drug in accordance with the command; and

wherein the control means selects a time period in which the indicator is changing according to a specified trend, and outputs a command to administer a drug when the trend of the change differs from a trend demonstrated by the indicator during a past time period.

10. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state;

a recording means for storing the indicator measured, up until a current point in time;

a control means for determining when a drug is to be administered based on a rhythm of variation displayed by the indicator over a specified period of time, and for outputting a drug emission command at a determined time;

an administering means for administering the drug in accordance with the drug emission command; and

a means for detecting an output of the drug emission command, determining from the point of this detection whether or not the indicator of the physiological state indicates a first state which does not require emission of a drug, and providing notification when the indicator of the physiological state has reached the first state.

11. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state;

a recording means for storing the indicator measured, up until a current point in time;

a control means for outputting a drug emission command based on a current indicator of the physiological state and on a rhythm of variation in the indicator over a specified period of time;

an administering means for administering a drug in accordance with the drug emission command; and

a means for detecting an output of the drug emission command, determining from the point of this detection whether or not the indicator of the physiological state indicates a first state which does not require emission of a drug, and providing notification when the indicator of the physiological state has reached the first state.

12. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state;

a recording means for storing the indicator measured, up until a current point in time;

a control means for determining in advance a time when a drug is to be administered based on circulatory indicators measured by the measuring means over a specific number of days in the past, and for outputting a drug emission command at the determined time; and

an administering means for administering the drug in accordance with the drug emission command.

13. A device for controlling a physiological state according to claim 12, wherein the administering means comprises an infuser of the drug.

14. A device for controlling a physiological state according to claim 12, wherein the administering means comprises an emission of the drug.

19. A device for controlling a physiological state according to claims 12 or 15, further comprising a first notification means for obtaining an amount of drug administered, and providing notification when the summed value of the administered amount reaches a specified amount.

20. A device for controlling a physiological state according to claim 19, comprising a second notification means for monitoring whether or not the emission of the drug is being carried out normally, and providing notification when an anomaly is present.

21. A device for controlling a physiological state according to claim 20, the device being portable, and comprising a battery and operating based on voltage supplied from the battery, and comprising an electricity supply control means intermittently supplying the voltage output from the battery to elements in the device.

22. A device for controlling a physiological state according to claim 21, further comprising a third notification means for providing notification when the voltage output from the battery falls below a specified voltage.

23. A device for controlling a physiological state according to claims 12 or 16, further comprising a blood pulse detection means for detecting in a body a blood pulse cycle blood output from a heart, wherein the control means issues a command to administer a drug during a time interval from one blood pulse beat to a next blood pulse beat in synchronization with the blood pulse cycle.

15. A device for controlling a physiological state, comprising:

a measuring means for measuring an indicator of a physiological state;

a recording means for storing the indicator measured, up until a current point in time;

a control means for outputting a drug emission command at a time determined in advance based on a current indicator of the physiological state and on circulatory indicators measured by the measuring means over specific number of days in the past; and

an administering means for administering a drug in accordance with the drug emission command.

16. A device for controlling a physiological state according to claim 15, wherein the administering means comprises an infuser of the drug.

17. A device for controlling a physiological state according to claim 15, wherein the control means selects a specified time period, and outputs a command to administer a drug when the indicator during the specified time period deviates a fixed amount above a moving average obtained in the past for the indicator.

18. A device for controlling a physiological state according to claim 15, wherein the administering means comprises an emission of the drug.