Stent lining
First Claim
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1. A method for lining a stent, comprising:
- (a) providing a catheter assembly comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel is crosslinked, wherein an expansible stent is mounted on said balloon in a contracted condition, (b) introducing said assembly into a body lumen, and (c) inflating said balloon to lodge said stent in said body lumen and to release said hydrogel from said coated portion to an inner surface of said stent as a lining.
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Abstract
The invention features a catheter assembly and methods for delivering a hydrogel-lined stent to a body lumen, and methods for lining a stent with a hydrogel. The assembly includes a catheter which has a balloon at least a portion of which is coated with a hydrogel and an expansible stent mounted on the balloon in a contracted condition for passage with the catheter to a site of a body. Expansion of the balloon lodges the stent in the body with hydrogel coated on the inner surfaces of the stent as a lining.
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Citations
81 Claims
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1. A method for lining a stent, comprising:
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(a) providing a catheter assembly comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel is crosslinked, wherein an expansible stent is mounted on said balloon in a contracted condition, (b) introducing said assembly into a body lumen, and (c) inflating said balloon to lodge said stent in said body lumen and to release said hydrogel from said coated portion to an inner surface of said stent as a lining. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of lining a stent positioned in a body lumen, comprising:
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(a) providing a catheter comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel is selected from the group consisting of a polyacid, cellulosic polymer, collagen, gelatin, albumin, alginate, poly-2-hydroxymethyl methyl acrylate (HEMA), polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyacrylamide, polyvinyl alcohol, polyethylene glycol, polyethylene oxide, and polysaccharide, (b) introducing said catheter into said body lumen, (c) advancing said catheter in said body lumen until said coated portion is positioned proximate to an inner surface of said stent; and
(d) inflating said balloon to release said hydrogel from said coated portion to said inner surface of said stent as a lining. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A method of lining a stent positioned in a body lumen, comprising:
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(a) providing a catheter comprising a balloon and a delivery port, wherein said balloon comprises a first layer and a second outer apertured layer overlying said delivery port, (b) introducing said catheter into said body lumen, (c) advancing said catheter in said body lumen until said outer apertured layer is positioned proximate to an inner surface of said stent;
(d) delivering a hydrogel into a space between said first layer and said second outer apertured layer, wherein said hydrogel is selected from the group consisting of a polyacid, cellulosic polymer, collagen, gelatin, albumin, alginate, poly-2-hydroxyethyl methyl acrylate (HEMA), polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyacrylamide, polyvinyl alcohol, polyethylene glycol, polyethylene oxide, and polysaccharide; and
(e) inflating said balloon to press said hydrogel through said outer apertured layer, wherein said hydrogel is deposited on said inner surface of said stent as a lining. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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64. A method of selectively lining a permeable stent to treat an aneurism, comprising:
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(a) providing a catheter comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel is selected from the group consisting of a polyacid, cellulosic polymer, collagen, gelatin, albumin, alginate, poly-2-hydroxyethyl methyl acrylate (HEMA), polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyacrylamide, polyvinyl alcohol, polyethylene glycol, polyethylene oxide, and polysaccharide;
(b) introducing said catheter into an aneurismal blood vessel comprising said permeable stent in the region of said aneurism, (c) advancing said catheter in said vessel until said coated portion is positioned proximate to said aneurism; and
(d) inflating said balloon to release said hydrogel from said coated portion to an inner surface of said stent proximate to said aneurism to selectively line said stent, wherein said hydrogel renders said surface impermeable thereby reducing blood flow into said aneurism. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
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Specification