Non-luminescent substrate

• US 6,890,483 B2
• Filed: 07/02/2001
• Issued: 05/10/2005
• Est. Priority Date: 07/05/2000
• Status: Expired due to Fees

• Current Assignee: 3M Innovative Properties Company (3M Company)
• Original Assignee: Cuno Incorporated
• Inventors: Andreoli, Rita J., Chesterson, Richard S.
• Primary Examiner(s): Snay, Jeffrey R.
• Application Number:
  US09/897,333
• Publication Number:
  US 20020019481A1
• Time in Patent Office: 1,408 Days
• Field of Search: 422/82.11, 422/55, 422/57, 422/82.08, 356/244, 436/165, 436/172
• US Class Current: 422/425
• CPC Class Codes: B01J 2219/00274 Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
• CPC Class Codes: B01J 2219/00576 fluorophore
• CPC Class Codes: B01J 2219/00641 the porous medium being continuous, e.g. porous oxide substrates
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: C07B 2200/11 Compounds covalently bound to a solid support
• CPC Class Codes: C07H 21/00 Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• CPC Class Codes: C40B 40/00 Libraries per se, e.g. arrays, mixtures
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
• CPC Class Codes: G01N 33/545 Synthetic resin
• CPC Class Codes: G01N 33/551 the carrier being inorganic

Abstract

A substantially non-reflective, low or non-fluorescing substrate comprising a phase-inversion support and a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and of a size sufficient to be partially or completely contained within, or intimately bound to, the phase inversion support. Methods of making and using the substantially non-reflective, low or non-fluorescing substrate are also disclosed.

Claims

1. A substantially non-reflective substrate which provides little fluorescence from about 300 nm to about 700 nm comprising:

a phase-inversion support; and

a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and intimately bound to, and/or partially/completely contained within, said phase-inversion support.

2. A substrate of claim 1 wherein the phase-inversion support comprises polyamides.

3. A substrate of claim 1 wherein the opaque solids are pigments.

4. A substrate of claim 1 wherein the opaque solids are carbon particles.

5. A substrate of claim 1 wherein the phase inversion support has been charge-modified.

6. A substrate of claim 4 wherein carbon particles are less than five microns in size.

7. A substrate of claim 4 wherein the carbon particles are substantially uniformly distributed throughout the polyamide support.

8. A substrate of claim 4 wherein the carbon particles are partially incorporated into the polyamide support.

9. A substrate of claim 4 wherein the carbon particles are substantially wholly incorporated into the polyamide support.

10. A substrate of claim 4 wherein the polyamide has been charge-modified.

11. An optically-passive substrate comprising a phase-inversion support and opaque solids that are substantially non-reactive chemically with the phase inversion support, in a weight ratio with said phase-inversion support such that said optically-passive substrate absorbs light at substantially all wave lengths from about 300 nm to about 700 nm.

12. An optically-passive substrate as recited in claim 11 wherein the phase-inversion support comprises polyamide.

13. An optically-passive substrate as recited in claim 12 wherein the phase-inversion support is in the form of a membrane.

14. An optically-passive substrate as recited in claim 12 wherein the opaque solids are carbon particles.

15. An optically-passive substrate as recited in claim 14 wherein carbon particles are less than about 5 microns in size.

16. A substrate of claim 14 wherein the carbon particles are substantially uniformly distributed throughout the polyamide support.

17. A substrate of claim 14 wherein the carbon particles are partially incorporated into the polyamide support.

18. A substrate of claim 14 wherein the carbon particles are substantially wholly incorporated into the polyamide support.

19. A substrate of claim 14 wherein the polyamide has been charge-modified.

20. A substrate as recited in claim 18 wherein the substrate absorbs light at substantially all wavelengths from about 300 to about 700 nm.

21. A substrate as recited in claim 20 wherein the substrate has a reflectance of no more than 50% of incident light at any wavelength within said range of wavelengths.

22. A substrate as recited in claim 11 wherein the phase-inversion support is hydrophilic.

23. A substrate as recited in claim 22 wherein the phase-inversion support is skinless.

24. A substrate as recited in claim 23 wherein the phase-inversion support comprises nylon.

25. A substrate as recited in claim 24 wherein the phase-inversion support is charge-modified.

26. A substrate comprising:

a phase-inversion support; and

a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and intimately bound thereto, and/or partially/completely contained within the phase-inversion support, the substrate having substantially reduced reflectance.

27. The substrate of claim 26 wherein the phase-inversion support comprises polyamides.

28. The substrate of claim 26 wherein the opaque solids are pigments.

29. The substrate of claim 26 wherein the opaque solids are carbon particles.

30. The substrate of claim 26 wherein the phase inversion support has been charge-modified.

31. The substrate of claim 29 wherein carbon particles are less than five microns in size.

32. The substrate of claim 29 wherein the carbon particles are substantially uniformly distributed throughout the polyamide support.

33. The substrate of claim 29 wherein the carbon particles are at least partially incorporated into the polyamide support.

34. The substrate of claim 29 wherein the carbon particles are substantially wholly incorporated into the polyamide support.

35. The substrate of claim 29 wherein the polyamide has been charge-modified.

36. The substrate of claim 26 wherein the phase-inversion support is in the form of a membrane.

37. The substrate of claim 26 wherein the reflectance is substantially reduced from about 300 nm to about 700 nm.

38. The substrate of claim 35 wherein the substrate has a reflectance of no more than 50% of incident light at any wavelength within the range of wavelengths.

39. The substrate of claim 26 wherein the phase-inversion support is hydrophilic.

40. The substrate of claim 39 wherein the phase-inversion support is skinless.

41. The substrate of claim 40 wherein the phase-inversion support comprises nylon.

42. The substrate of claim 26 wherein the phase-inversion support is charge-modified.

43. A substrate which provides little fluorescence from about 300 nm to about 700 nm comprising:

a phase-inversion support; and

a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and intimately bound to, and/or partially/completely contained within, said phase-inversion support, the substrate having substantially reduced reflectance.

44. The substrate of claim 43 wherein the opaque solids are fibers.