Compositions of chemically modified insulin
First Claim
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1. A polymer conjugate comprising proinsulin covalently attached to one or more molecules of polyethylene glycol.
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Abstract
The present invention provides active, hydrophilic polymer-modified derivatives of insulin. The insulin derivatives of the invention are, in one aspect, suitable for delivery to the lung and exhibit pharmakokinetic and/or pharmacodynamic properties that are significantly improved over native insulin.
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19 Claims
- 1. A polymer conjugate comprising proinsulin covalently attached to one or more molecules of polyethylene glycol.
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