Pharmaceutical compositions including ACE/NEP inhibitors and bioavailability enhancers
First Claim
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1. A pharmaceutical composition comprising at least one dual inhibitor of angiotensin converting enzyme and neutral endopeptidase, and at least one bioavailability enhancer selected from ascorbic acid, citric acid, malic acid, fumaric acid, and pharmaceutically acceptable salts of said acids.
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Abstract
A pharmaceutical composition comprising an inhibitor of angiotensin converting enzyme and neutral endopeptidase, such as sampatrilat, and at least one bioavailability enhancer such as an organic acid, e.g., ascorbic acid. Such a composition has improved systemic bioavailability.
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18 Claims
- 1. A pharmaceutical composition comprising at least one dual inhibitor of angiotensin converting enzyme and neutral endopeptidase, and at least one bioavailability enhancer selected from ascorbic acid, citric acid, malic acid, fumaric acid, and pharmaceutically acceptable salts of said acids.
- 17. A process for preparing a pharmaceutical composition, comprising combining at least one agent, in powder form, selected from the group consisting of dual inhibitors of angiotensin convening enzyme and neutral endopeptidase, with at least one bioavailability enhancer selected from ascorbic acid, citric acid, malic acid, fumaric acid, and pharmaceutically acceptable salts of said acids, also in powder form to obtain a powdered mixture and either (a) encapsulating said powdered mixture in a capsule or (b) forming said powdered mixture into a tablet.
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