Reaction device for organic synthesis

• US 6,893,614 B2
• Filed: 02/16/2001
• Issued: 05/17/2005
• Est. Priority Date: 03/29/2000
• Status: Active Grant

• Current Assignee: Peptron, Inc.
• Original Assignee: Peptron, Inc.
• Inventors: Kim, Sun-Young, Chang, Seung-Gu, Choi, Ho-Il, Kim, Seong-Kyu, Bang, Jeong-Kyu
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US09/980,050
• Publication Number:
  US 20030026745A1
• Time in Patent Office: 1,551 Days
• Field of Search: 422/131, 422/101, 422/102, 422/103, 422/104, 435/287.2, 435/288.3, 435/305.3, 530/334
• US Class Current: 422/131
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00281 Individual reactor vessels
• CPC Class Codes: B01J 2219/00283 Reactor vessels with top opening
• CPC Class Codes: B01J 2219/00308 interchangeably mounted in racks or blocks
• CPC Class Codes: B01J 2219/00394 in multiple arrangements
• CPC Class Codes: B01J 2219/00416 Vacuum
• CPC Class Codes: B01J 2219/00418 using pressure
• CPC Class Codes: B01J 2219/00423 using filtration, e.g. through porous frits
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/00596 Solid-phase processes
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01J 2219/00725 Peptides
• CPC Class Codes: C07B 2200/11 Compounds covalently bound to a solid support
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07K 1/045 using devices to improve synthesis, e.g. reactors, special vessels
• CPC Class Codes: C40B 40/06 Libraries containing nucleotides or polynucleotides, or derivatives thereof
• CPC Class Codes: C40B 40/10 Libraries containing peptides or polypeptides, or derivatives thereof
• CPC Class Codes: C40B 60/14 for creating libraries

Abstract

The present invention relates to a reaction vessel for organic synthesis and a block device for the reaction vessel and synthetic method of compound using thereof. More particularly, the present invention provides a solid phase synthetic reaction vessel and a block device for the reaction vessels which are capable of simultaneously synthesizing chemical libraries by combinatorial chemistry method automatically or semiautomatically.

Claims

1. An organic synthesis reaction vessel in the form of a single hollow tube as a whole, comprising;

a horizontal part;

a vertical part formed by bending upward from an end of the said horizontal part;

an inlet formed by bending upward from the other end of the said horizontal part;

an outlet formed by bending the upper part of the said vertical part in parallel with the said horizontal part in the opposite direction to the said inlet and engaged with a connection joint;

and a filter mounted within one end of the said horizontal part or the said vertical part.

2. The organic synthesis reaction vessel of the claim 1 wherein the filter is a organic solvent resistant filter.

5. A method for synthesizing a compound or a library of compounds by using the organic synthesis reaction vessel of the claim 1 or 2 and the block device for reaction vessels of the claim 3 or 4.

6. The method of the claim 5 wherein the compound is a peptide.

7. The method of the claim 5 wherein the compound is a oligonucleotide.

3. A block device for reaction vessels, comprising;

a hexahedral frame whose front is capable of getting closed or opened;

a block contacting with the inner face of the rear side and inner faces of both sides of the said frame without a gap and having a vacuum passage going through both sides of the said frame horizontally, a plurality of cock grooves formed in the upper part in a specific intervals and depth;

connection joint insertion grooves formed in the front part in the same intervals with the said cock grooves so as to connect to the said cock grooves;

a plurality of small vacuum tubes formed in the same intervals with the said cock grooves and connecting the said cock grooves and the said vacuum passage; and

a plurality of sample outlets connecting the outer face of the rear side of the said frame to the said cock grooves;

a plurality of cocks having the connection joint insertion groove, the said small vacuum tube, and a first and a second passage connecting the said connection joint insertion groove and the said outlet respectively, and rotating after inserted into the said cock grooves without a gap;

a catch projection extending from the said vacuum passage in the outside of one side of the said hexahedral frame;

a catch groove capable of closely engaging with the said catch projection and stopper without a gap in the other side which is connected to the said catch projection by the vacuum passage.

4. The block device for reaction vessels of the claim 3 wherein the fame further comprises a cover having a hole capable of blowing gases into in the upper face of the frame.