Antitachycardial pacing

• US 6,895,274 B2
• Filed: 08/14/2001
• Issued: 05/17/2005
• Est. Priority Date: 08/19/1996
• Status: Expired due to Fees

• Current Assignee: MR3 Medical, LLC
• Original Assignee: Mower Family Chf Treatment Irrevocable Trust
• Inventors: Mower, Morton M.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/929,478
• Publication Number:
  US 20020095188A1
• Time in Patent Office: 1,372 Days
• Field of Search: 607 4- 8, 607/14
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Protocols for antitachycardial pacing including biphasic stimulation administered at, or just above, the diastolic depolarization threshold potential; biphasic or conventional stimulation initiated at, or just above, the diastolic depolarization threshold potential, reduced, upon capture, to below threshold; and biphasic or conventional stimulation administered at a level set just below the diastolic depolarization threshold potential. These protocols result in reliable cardiac capture with a lower stimulation level, thereby causing less damage to the heart, extending battery life, causing less pain to the patient and having greater therapeutic effectiveness. In those protocols using biphasic cardiac pacing, a first and second stimulation phase is administered. The first stimulation phase has a predefined polarity, amplitude and duration. The second stimulation phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is improved together with the increase in contractility.

Claims

1. A method of operating an implantable cardiac stimulator to perform cardioverting, the cardiac stimulator having output means for delivering electrical stimulation of a predetermined polarity, amplitude, shape and duration, the method comprising:

sensing the onset of tachycardia;

applying pulses of biphasic pacing stimulation at a first intensity level selected from the group consisting of at the diastolic depolarization threshold, below the diastolic depolarization threshold or above the diastolic depolarization threshold, wherein each pulse of biphasic pacing stimulation comprises;

a first stimulation phase with a first phase polarity,

a first phase amplitude, a first phase shape and a first phase duration; and

a second stimulation phase with a second phase polarity, a second phase amplitude, a second phase shape and a second phase duration; and

determining whether pacing capture has occurred;

wherein the first phase polarity is positive and the first phase amplitude is at a maximum subthreshold amplitude.

2. The method of operating an implantable cardiac stimulator as in claim 1, wherein it is determined that capture has not occurred, further comprising:

increasing the stimulation intensity level by predefined increments until capture occurs.

3. The method of operating an implantable cardiac stimulator as in claim 1, wherein it is determined that capture has occurred, further comprising:

halting biphasic pacing stimulation.

4. The method of operating an implantable cardiac stimulator as in claim 1, wherein the first phase duration is at least as long as the second phase duration.

5. The method of operating an implantable cardiac stimulator as in claim 1, wherein the first stimulation phase is initiated greater than 200 milliseconds after completion of a cardiac beating cycle.

6. An implantable cardiac stimulator to perform cardioverting, the cardiac stimulator comprising:

sensing means for sensing the onset of tachycardia;

output means for delivering, in response to the sensing means, electrical stimulation of a predetermined polarity, amplitude, shape and duration to cause application of pulses of biphasic pacing stimulation at a first intensity level selected from the group consisting of;

at the diastolic depolarization threshold, below the diastolic depolarization threshold, and above the diastolic depolarization threshold; and

means for determining whether capture has occurred;

wherein each pulse of biphasic pacing stimulation comprises;

a first stimulation phase with a first phase polarity, a first phase amplitude, a first phase shape and a first phase duration; and

a second stimulation phase with a second phase polarity, a second phase amplitude, a second phase shape and a second phase duration;

wherein the first phase polarity is positive and the first phase amplitude is at a maximum subthreshold amplitude.

7. The cardiac stimulator as in claim 6, wherein in the event that the means for determining determines that capture has not occurred, the output means increases the stimulation intensity level by predefined increments until capture occurs.

8. The cardiac stimulator as in claim 6, wherein in the event that the means for determining determines that capture has occurred, the output means halts biphasic stimulation.

9. The cardiac stimulator as in claim 6, wherein the first phase duration is at least as long as the second phase duration.

10. An implantable cardiac stimulator device comprising:

plural electrodes;

sensing circuitry connected to the plural electrodes and adapted to sense the onset of tachycardia;

detecting circuitry connected to the sensing circuitry and adapted to detect whether pacing capture has occurred; and

pulse generating circuitry connected to the plural electrodes and adapted to generate, in response to the sensing circuitry, electrical pulses of a predetermined polarity, amplitude, shape and duration to cause application of pulses of biphasic pacing stimulation at a first intensity level selected from the group consisting of;

at the diastolic depolarization threshold, below the diastolic depolarization threshold, and above the diastolic depolarization threshold; and

wherein each pulse of biphasic pacing stimulation comprises;

a first stimulation phase with a first phase polarity, a first phase amplitude, a first phase shape and a first phase duration; and

a second stimulation phase with a second phase polarity, a second phase amplitude, a second phase shape and a second phase duration;

wherein the first phase polarity is positive and the first phase amplitude is at a maximum subthreshold amplitude.

11. The implantable cardiac stimulator device as in claim 10, wherein, in the event that the detecting circuitry determines that capture has not occurred, the pulse generating circuitry increases the stimulation intensity level by predefined increments until capture occurs.

12. The implantable cardiac stimulator device as in claim 10, wherein, in the event that the detecting circuitry determines that capture has occurred, the pulse generating circuitry halts biphasic pacing stimulation.