Therapeutic decisions systems and method using stochastic techniques
First Claim
1. A system comprising:
- a monitoring device monitoring a plurality of physiological signals of a current patient;
a database, which stores records indicative of a plurality of patients including at least some of said physiological signals for said plurality of patients and prognosis information for said plurality of patients;
a processor, comparing said physiological signals to said stored records in a database, to determine mathematically patients in the database which are most similar to a current patient; and
to make available information about treatment and results for said patients who are most similar to the current patient;
wherein said physiological signals include hemodynamic information; and
wherein said processor also carries out interpolation to place a plurality of said signals on a common time grid.
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Abstract
Patients are evaluated in terms of various physiological parameters such as hemodynamic parameters. Covariate information indicative of the patient'"'"'s individual characteristics may also be determined. A state variable indicative of the patient'"'"'s characteristics is determined. This state variable is used to compare the patient to other patients in the database. The other patients in the database are evaluated in terms of similar parameters and their probability of survival as well as different treatments and the probability of survival based on those different treatments. The patient may be simply evaluated based on the database or a proper course of treatments may be determined based on the database.
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Citations
21 Claims
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1. A system comprising:
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a monitoring device monitoring a plurality of physiological signals of a current patient;
a database, which stores records indicative of a plurality of patients including at least some of said physiological signals for said plurality of patients and prognosis information for said plurality of patients;
a processor, comparing said physiological signals to said stored records in a database, to determine mathematically patients in the database which are most similar to a current patient; and
to make available information about treatment and results for said patients who are most similar to the current patient;
wherein said physiological signals include hemodynamic information; and
wherein said processor also carries out interpolation to place a plurality of said signals on a common time grid.
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2. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the current patient;
determining information about treatments and results for said patients who are most similar to the current patient, wherein said physiological signals include signals indicative of hemodynamic information;
obtaining covariate information indicative of a patient'"'"'s individual characteristics, and wherein the steps of determining most similar patients and of determining information are also based on said covariate information; and
wherein said determining most similar patients comprises mathematically determining a state variable indicative of the current patient based on at least said hemodynamic information and said covariate information.
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3. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the current patient;
determining information about treatments and results for said patients who are most similar to the current patient;
wherein said physiological signals include signals indicative of hemodynamic information;
obtaining covariate information indicative of a patient'"'"'s individual characteristics, and wherein the steps of determining most similar patients and of determining information are also based on said covariate information;
wherein said determining most similar patients comprises mathematically determining a state variable indicative of the current patient based on said hemodynamic information and said covasiate information; and
wherein said determining a state variable comprises investigating derivatives of the hemodynamic information and integrals of the hemodynamic information.
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4. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the current patient;
determining information about treatments and results for said patients who are most similar to the current patient; and
wherein said determining patient a comprises determining quadratic distances between a state variable representing the current patient and state variables representing other patients in said database. - View Dependent Claims (5, 6)
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7. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the current patient;
determining information about treatments and results for said patients who are most similar to the current patient; and
wherein said comparing comprises interpolating among said physiological signals to evaluate said physiological signals on a common time scale.
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8. A system comprising:
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a monitoring device monitoring a plurality of physiological signals of a current patient;
a database, which stores records indicative of a plurality of patients including at least some of said physiological signals for said plurality of patients and prognosis information for said plurality of patients;
a processor, comparing said physiological signals which include hemodynamic information of the current patient to said stored records in the database, to determine mathematically patients in the database which are most similar to the current patient; and
to make available information about treatment and results for said patients why are most similar to the current patient; and
wherein said processor obtains covariate information indicative of a patient'"'"'s individual characteristics, wherein said processor mathematically determines said similar patients by determining a state variable for a patient based on at least said hemodynamic information and said covariate information. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the current patient;
determining information about treatments and results for said patients who are most similar to the current patient; and
wherein said determining information comprises modeling said patient as a control system with a state parameter representing a patient'"'"'s state, a control input representing a therapy, and a nonlinear dynamic system, with process noise being explained in terms of covariate information indicative of a patients individual characteristics.
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19. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the current patient; and
determining information about treatments and results for said patients who are most similar to the current patient, wherein said determining information comprises determining a likelihood that the patient will survive.
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20. A method, comprising:
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monitoring a plurality of physiological signals of a current patient;
comparing said physiological signals of the current patient to stored physiological signals for previous patients stored in a database;
determining patients in said database who are most similar to the currant patient;
determining information about treatments and results for said patiently who are most similar to the current patient, wherein said determining information comprises determining a therapy for the current patient which has proved most statistically successful for said patients who are most similar to the current patient.
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21. A method, comprising:
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determining hemodynamic characteristics of an individual patient;
determining covariate parameters of the individual patient representing the patient'"'"'s individual characteristics;
using said covariate characteristics and said hemodynamic parameters to develop a state variable that represents information that is continuously variable in time;
comparing said state variable with information indicative of a plurality of previously treated patients in a database; and
obtaining survival information about said patients in said database.
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Specification