Method for applying an LbL coating onto a medical device

• US 6,896,926 B2
• Filed: 09/03/2003
• Issued: 05/24/2005
• Est. Priority Date: 09/11/2002
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Lally, John Martin, Winterton, Lynn Cook, Qiu, Yongxing, Matsuzawa, Yasuo
• Primary Examiner(s): Michener, Jennifer Kolb
• Application Number:
  US10/654,340
• Publication Number:
  US 20040047979A1
• Time in Patent Office: 629 Days
• Field of Search: 427/2.1, 427/2.24, 427/2.31, 427/402, 427/407.1, 427414-415, 427/421, 427/430.1
• US Class Current: 427/2.31
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: B05D 1/185 applying monomolecular layers B05D1/204 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.

Claims

1. A method for applying a biocompatible layer-by-layer coating onto a medical device, comprising the steps of:

(a) contacting said medical device with a first coating solution containing a first polyionic material to non-covalently apply an innermost layer of the first polyionic material onto said medical device, and wherein prior to contacting with the first coating solution said medical device is not subjected to a surface modification;

(b) contacting said medical device having the innermost layer of the first polyionic material with a second ccating solution containing a second polyionic material, to form a first polyelectrolyte bilayer consisting of the innermost layer of the first polyionic material and one layer of the second polyionic material on top of the innermost layer, wherein the second polyionic material has charges opposite of the charges of the first polyionic material;

(c) contacting said medical device having the first polyelectrolyte bilayer with a third coating solution containing the first polyionic material or a third polyionic material, to form a layer of the first polyionic material or the third polyionic material on top of the first polyelectrolyte poilayer, wherein the third polyionic material has charges opposite of the charges of the second polyionic material;

(d) contacting said medical device having the first polyelectrolyte bilayer and one layer of the first polyionic material or the third polyionic material on top of the first polyelectrolyte bilayer with a fourth coating solution containing the second polyionic material or a fourth polyionic material having charges opposite of the charges of the first or third polyionic material, to form a second pelyelectrolyte bilayer consisting of the layer of the first polyionic material or the third polyionic material and one layer of the second material; and

, optionally,

(e) repeating steps (c) and (d) for a number of times to build up additional polyelectrolyte bilayers until formation of the layer by layer coating on the medical device,

wherein the concentration of the first polyionic material in said first coating solution is selected to be at least ten times higher than the concentration of any polyionic material in any coating solution other than the first coating solution so as to impart to the layer-by-layer coating a relatively high hydrophilicity characterized by an averaged contact angle of less than about 54 degrees.

2. A method of claim 1, comprising at least a rinsing step between steps (a) and (b), between steps (b) and (c), between steps (c) and (d), or between steps (d) and (c), wherein the rinsing step is carried out by contacting said medical device with a rinsing solution.

3. A method of claim 1, comprising no rinsing step between steps (a) and (b), between steps (b) and (c), between steps (c) and (d), or between steps (d) and (c).

4. A method of claim 1, wherein at least one of said contacting occurs by spraying a solution onto the medical device.

5. A method of claim 1, wherein at least one of said contacting occurs by dipping said medical device into a coating solution.

6. A method of claim 1, wherein said method comprises repeating steps (a) through (d) between 3 to 20 times.

7. A method of claim 1, wherein the concentration of the first polyionic material in said first coating solution is from 10 to 25 folds of the concentration of the first, second, third, or fourth polyionic material in the second, third or fourth coating solution.

8. A method of claim 1, wherein the third coating solution contains the first polyionic material.

9. A method of claim 1, wherein the third coating solution contains the third polyionic material.

10. A method of claim 1, wherein the fourth coating solution contains the second polyionic material.

11. A method of claim 1, wherein the fourth coating solution contains the fourth polyionic material.

12. A method of claim 1, wherein at least three different polyionic materials are used in forming the biocompatible LbL coating on said medical device.

13. A method of claim 1, wherein the biocompatible LbL coating comprises at least one layer of a lubricious coating material or a polyquat, wherein the lubricious coating material is selected from the group consisting of polyaminoamide dendrimers, polyacrylamide-polyacrylic acid copolymers (PAAm-co-PAA), polyvinylpyrrolidone/polyacrylic acid copolymers (PVP-co-PAA), glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextrans, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides.