Moving table MRI with frequency-encoding in the z-direction

• US 6,897,655 B2
• Filed: 09/04/2002
• Issued: 05/24/2005
• Est. Priority Date: 03/30/2001
• Status: Expired due to Term

• Current Assignee: General Electric Company, Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: General Electric Company, Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Pauly, John M., Brittain, Jean H.
• Primary Examiner(s): Bennett, G. Bradley
• Assistant Examiner(s): Fetzner, Tiffany A.
• Application Number:
  US10/235,454
• Publication Number:
  US 20030011369A1
• Time in Patent Office: 993 Days
• Field of Search: 600/410, 600/420, 600407-423, 324/309, 324/318, 324/307, 324300-322
• US Class Current: 324/309
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/54 Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
• CPC Class Codes: G01R 33/56375 Intentional motion of the sample during MR, e.g. moving table imaging
• CPC Class Codes: G01R 33/56383 involving motion of the sample as a whole, e.g. multistation MR or MR with continuous table motion

Abstract

A system and method are disclosed using continuous table motion while acquiring data to reconstruct MR images across a large FOV without significant slab-boundary artifacts that reduces acquisition time. At each table position, full z-encoding data are acquired for a subset of the transverse k-space data. The table is moved through a number of positions over the desired FOV and MR data are acquired over the plurality of table positions. Since full z-data are acquired for each slab, the data can be Fourier transformed in z, interpolated, sorted, and aligned to match anatomic z locations. The fully sampled and aligned data is then Fourier transformed in remaining dimension(s) to reconstruct the final image that is free of slab-boundary artifacts.

Claims

1. A method of imaging large volumes without resulting slab-boundary artifacts, the method comprising:

defining a desired FOV larger than an optimal imaging volume of an MR scanner in at least a first direction;

defining desired phase encode locations in at least one dimension perpendicular to the first direction;

choosing a plurality of slab thicknesses in the first direction wherein slab thickness varies with each phase encode location and is smaller than the desired FOV and within the optimal imaging volume of the MR scanner; and

continuously moving one of the optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with readout in the first direction to acquire data that is restricted to a slab thickness for a set of phase encode locations until a set of MR data for the FOV for the first set of phase encode locations is acquired;

reversing the direction of motion of one of the optimal imaging volume and the imaging object in the first direction;

continuously moving one of the optimal imaging volume and the imaging object in the a reversed direction while repeatedly exciting and encoding spins with readout in the first direction to acquire data that is restricted to the slab thickness for a second set of phase encode locations until a set of MR data for the FOV for the second set of phase encode locations is acquired; and

reconstructing at least one image of the FOV from the set of MR data for the first set of phase encode locations and the set of MR data for the second set of phase encode locations.

2. The method of claim 1 wherein the phase encode locations are divided into a number of sets and wherein each set has a constant slab thickness.

3. The method of claim 1 further comprising acquiring multiple lines of data following a single excitation to minimize overall scan time.

4. The method of claim 1, further comprising selecting a set of phase encode locations to be proximate to a center of k-space in a transverse direction and timing acquisition of the set of phase encode locations to capture optimal image contrast associated with passage of a bolus of extrinsic contrast agent.

5. The method of claim 1 further comprising interleaving with a pre-defined temporal frequency between the exciting and encoding waveforms and alternate RF and gradient waveforms to manipulate image contrast.

6. The method of claim 5 further comprising alternate RF and gradient waveforms designed to manipulate spins in spatially localized regions relative to the slab.

7. The method of claim 1 further comprising acquiring MR data associated with multiple phase encode locations following a single excitation.

8. The method of claim 1 further comprising acquiring MR data associated with a single phase encode location multiple times following a single excitation.

9. The method of claim 1 further comprising acquiring MR data with different temporal frequencies for reconstructing an image and further comprising tracking a relative motion of the optimal imaging volume and the imaging object.

10. The method of claim 1 wherein acquiring MR data includes frequency encoding in the first direction.

11. The method of claim 1 further comprising reconstructing the at least one image of the FOV by:

altering a phase of the acquired MR data to correct for motion;

Fourier transforming the MR data in the first direction; and

sorting and aligning the transformed data to match anatomical locations.

12. The method of claim 11 further comprising reconstructing the at least one image of the FOV by transforming the MR data in remaining transverse dimension(s).

13. The method of claim 11 further comprising gridding and transforming the MR data in dimension(s) perpendicular to the first direction.

14. The method of claim 11 further comprising separately correcting each line of MR data for gradient non-linearities after transforming in the first direction.

15. A method of imaging large volumes without resulting slab-boundary artifacts, the method comprising:

defining a desired FOV larger than an optimal imaging volume of an MR scanner in at least a first direction;

defining desired phase encode locations in at least one dimension perpendicular to the first direction;

enabling readout in the first direction;

choosing a plurality of slab thicknesses in the first direction wherein slab thickness varies with each phase encode location and is smaller than the desired FOV and within the optimal imaging volume of the MR scanner; and

continuously moving one of the optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with readout in the first direction to acquire MR data that is restricted to a chosen slab thickness for the phase encode location being encoded until at least one image of the FOV can be reconstructed by;

altering a phase of the acquired MR data to correct for motion;

Fourier transforming the MR data in the first direction;

gridding and transforming the MR data in at least one dimension perpendicular to the first direction; and

sorting and aligning the transformed data to match anatomical locations.

16. A computer readable storage medium having stored thereon a computer program to control a medical imaging device and create large FOV images without boundary artifacts, the computer program having a set of instructions that when executed by a computer causes the computer to:

define a desired FOV larger than an optimal imaging volume of an MR scanner in at least a first direction;

determine a slab in the first direction having a thickness that is smaller than the desired FOV and within the optimal imaging volume of the MR scanner;

define readout in a first direction;

select a set of phase encode locations to be proximate to a center of k-space in a transverse direction to the first direction and timing acquisition of the set of phase encode locations to capture optimal image contrast associated with passage of a bolus of extrinsic contrast agent; and

continuously move one of the optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with readout in the first direction to acquire data that is restricted to the slab until at least one image of the FOV can be reconstructed.

17. The computer readable storage medium of claim 16 wherein the computer program has further instructions to cause the computer to acquire the data using frequency encoding in a direction of table motion.

18. The computer readable storage medium of claim 16 wherein the computer program has further instructions to cause the computer to:

alter a phase of the acquired MR data to correct for motion;

Fourier transform the data in the first direction; and

sort and align the transformed data to match anatomical locations.

19. The computer readable storage medium of claim 18 wherein the computer has further instructions to separately correct each line of MR data for gradient non-linearities after transforming in the first direction.

20. The computer readable storage medium of claim 18 wherein the computer has further instructions to reconstruct an MR image by transforming the MR data in remaining transverse dimension(s).

21. The computer readable storage medium of claim 18 wherein the computer has further instructions to grid and then transform the MR data in dimension(s) perpendicular to the first direction.

22. The computer readable storage medium of claim 16 wherein the computer program has further instructions to cause the computer to track continuous movement of the optimal imaging volume with respect to the imaging object.

23. The computer readable storage medium of claim 16 wherein the computer program has further instructions to cause the computer to do at least one of:

apply an echo planar readout in a direction of table motion;

determine at least one of table position and table velocity;

determine phase encode locations; and

determine a data acquisition order.

24. An MRI apparatus, to acquire multiple sets of MR data with a moving table and reconstruct MR images without slab-boundary artifacts, the apparatus comprising:

a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly designed to acquire MR images;

a patient table movable fore and aft in the MRI system within the magnet bore; and

a computer programmed to;

receive input defining a desired FOV larger than an optimal imaging volume of the MRI system in at least a first direction;

define desired phase encode locations in at least one dimension perpendicular to the first direction;

divide desired phase encode locations into sets;

choose at least one slab thickness in the first direction wherein slab thickness is constant for each set of phase encode locations and is smaller than the desired FOV and within the optimal imaging volume of the MR scanner;

readout in the first direction;

continuously move one of the optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with readout in the first direction to acquire data restricted to the slab thickness for the defined phase encode locations until at least one image of the FOV can be reconstructed; and

correct for gradient non-linearities.

25. The MRI apparatus of claim 24 wherein the computer is further programmed to transmit magnetic gradient waveforms to acquire data with frequency encoding in a direction of table motion.

26. The MRI apparatus of claim 24 wherein the computer is further programmed to:

transform MR data in the first direction;

align the transformed MR data to match anatomy across slab boundaries; and

transform the data with respect to at least one remaining dimension to reconstruct an MR image.

27. The MRI apparatus of claim 24 wherein the computer is further programmed to:

apply an RF pulse to excite a volume of interest;

apply a k-space trajectory to encode the volume of interest; and

filter the acquired MR data to restrict the MR data to the defined slab.

28. The MRI apparatus of claim 24 wherein the computer is further programmed to acquire MR data and track MR data using different temporal frequencies.

29. The MRI apparatus of claim 24 wherein the computer is further programmed to:

acquire k-space data for the first direction for a selected subset of transverse k-space data;

define a set of magnetic field gradient waveforms to incrementally encode and acquire data in a given slab; and

apply the set of magnetic field gradient waveforms in a cyclic order.

30. A method of imaging large volumes without resulting slab-boundary artifacts, the method comprising:

(A) defining a desired FOV larger than an optimal imaging volume of an MR scanner in at least a first direction;

(B) defining desired phase encode locations in at least one direction perpendicular to the first direction;

(C) dividing desired phase encode locations into sets;

(D) choosing at least one slab thickness in the first direction, wherein slab thickness is constant for each set of phase encode location and is smaller than the desired FOV and within the optimal imaging volume of the MR scanner;

(E) frequency encoding in the first direction;

(F) continuously moving one of optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with readout in the first direction to acquire data that is restricted to a slab thickness for a first set of phase encode locations until a set of MR data for the first set of phase encode locations is acquired for the entire FOV;

(G) reversing the direction of motion of one of the optimal imaging volume and the imaging object;

(H) continuously moving one of the optimal imaging volume and the imaging object in a reverse direction while repeatedly exciting and encoding spins with readout in the first direction to acquire data that is restricted to the slab thickness for a next set of phase encode locations until a set of MR data for the next set of phase encode locations is acquired; and

(I) reconstructing at least one image of the FOV from the acquired sets of MR data.

31. The method of claim 30 further comprising repeating (F) through (G) for each remaining set of phase encode locations until at least one image of the FOV can be reconstructed from the sets of MR data.

32. The method of claim 30 further comprising selecting a set of phase encode locations to be proximate to a center of k-space in a transverse direction and timing the acquisition of the set of phase encode locations to capture optimal image contrast associated with passage of a bolus of extrinsic contrast agent.

33. The method of claim 30 further comprising:

altering a phase of MR data to account for motion;

transforming the sets of MR data in the first direction; and

sorting, interpolating, and aligning the transformed sets of MR data to match anatomic locations in the first direction.

34. The method of claim 33 further comprising gridding and transforming the transformed MR data in dimension(s) perpendicular to the first direction to reconstruct an MR image.

35. The method of claim 33 further comprising reconstructing an MR image by transforming the transformed MR data in remaining transverse dimension(s).

36. An controller for imaging large volumes without resulting slab-boundary artifacts, the controller having a set of instructions that causes the controller to:

define a desired FOV larger than an optimal imaging volume of an MR scanner in at least a first direction, the desired FOV having a number of sets of phase encode locations;

choose at least one slab thickness in the first direction wherein the at least one slab thickness is constant for each set of phase encode locations and is smaller than the desired FOV and within the optimal imaging volume of the MR scanner;

frequency encode in the first direction;

translate one of the optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with a first combination of exciting and encoding waveforms and with readout in the first direction to acquire MR data that is restricted to a slab thickness of a phase encode location; and

interleave a pre-defined temporal frequency between the first combination of exciting and encoding waveforms with another combination of RF and gradient waveforms configured to excite and encode spins outside the slab thickness-until at least one image of the FOV can be reconstructed.

37. The controller of claim 36 wherein the set of instructions further causes the controller to interleave alternate combinations of RF and gradient waveforms to manipulate spins in spatially localized regions relative to the slab.

38. The controller of claim 36 wherein the set of instructions further causes the controller to interleave alternate combinations of RF and gradient waveforms to manipulate spins in a specific spectral range.

39. A system for imaging large volumes without resulting slab-boundary artifacts, the system comprising:

means for defining a desired FOV larger than an optimal imaging volume of an MR scanner in at least a first direction;

means for defining desired phase encode locations in at least one dimension perpendicular to the first direction;

means for dividing desired phase encode locations into sets;

means for defining readout in the first direction;

means for choosing at least one slab thickness in the first direction, wherein slab thickness is constant for each set of phase encode locations and is smaller than the desired FOV and within the optimal imaging volume of the MR scanner; and

means for continuously moving one of the optimal imaging volume and an imaging object in the first direction while repeatedly exciting and encoding spins with readout in the first direction to acquire multiple lines of MR data following each excitation until at least one image of the FOV can be reconstructed.

40. The system of claim 39 further comprising means for acquiring MR data associated with multiple phase encode locations following each excitation.

41. The system of claim 39 further comprising means for acquiring multiple sets of MR data associated with a single phase encode location following each excitation.