Non-invasive blood analyte measuring system and method utilizing optical absorption
First Claim
1. A method of non-invasively measuring the concentration of one or more blood analytes in a portion of tissue of a human or animal comprising the steps of:
- positioning the portion of tissue near a light source and one or more sensors such that infrared radiation transmitted by the light source is reflected from or transmitted through the portion of tissue and onto the one or more sensors;
exposing the portion of tissue to infrared radiation from the light source;
detecting the infrared radiation transmitted or reflected from the portion of tissue with the one or more sensors;
generating spectral data from the one or more sensors in response to receiving the infrared radiation and communicating the spectral data to a processor;
determining the concentration of one or more blood analytes by orthogonal analysis using self calibration of the spectral data in which the ratio of blood analyte to a blood reference material is used; and
displaying the concentration of the one or more blood analytes.
1 Assignment
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Accused Products
Abstract
A device and method for measuring the concentration of analytes in the blood of a portion of tissue. The device includes a sensor module, a monitor, and a processor (separate from or integral with the sensor module). The sensor module includes a radiation source for emitting radiation to the tissue; a collimator and narrow band filter for processing the radiation after it has transmitted through or been reflected by the tissue; and one or more sensors for sensing the transmitted or reflected radiation. The one or more sensors send a signal to the processor which algorithmically converts the radiation using linear regression or orthogonal functions to determine the concentration of one or more blood analytes. The device self-calibrates to eliminate error caused by variables such as skin character. The sensor module is integrated to reduce size and weight such that it is inobtrusive, and the monitor is compact for transport
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Citations
31 Claims
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1. A method of non-invasively measuring the concentration of one or more blood analytes in a portion of tissue of a human or animal comprising the steps of:
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positioning the portion of tissue near a light source and one or more sensors such that infrared radiation transmitted by the light source is reflected from or transmitted through the portion of tissue and onto the one or more sensors;
exposing the portion of tissue to infrared radiation from the light source;
detecting the infrared radiation transmitted or reflected from the portion of tissue with the one or more sensors;
generating spectral data from the one or more sensors in response to receiving the infrared radiation and communicating the spectral data to a processor;
determining the concentration of one or more blood analytes by orthogonal analysis using self calibration of the spectral data in which the ratio of blood analyte to a blood reference material is used; and
displaying the concentration of the one or more blood analytes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of detecting injury or fatigue in humans or animals including the steps of:
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positioning a portion of tissue near a light source and one or more sensors such that infrared radiation transmitted by the light source is reflected from or transmitted through the portion of tissue and onto the one or more sensors;
exposing the portion of tissue to infrared radiation from the light source;
detecting the infrared radiation transmitted or reflected from the portion of tissue with the one or more sensors;
generating spectral data from the one or more sensors in response to receiving the infrared radiation and communicating the spectral data to a processor;
determining the concentration of lactic acid by orthogonal analysis using weighting functions and self calibration of the spectral data in which the ratio of lactic acid to a blood reference material is used; and
displaying the concentration of the lactic acid. - View Dependent Claims (12, 13)
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14. A mobile apparatus for the non-invasive measurement of the concentration of one or more blood analytes in the blood of a portion of tissue comprising:
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a light source for generating a spectrum of infrared radiation and transmitting the spectrum of radiation to the portion of tissue;
one or more sensors for detecting radiation from the portion of tissue over a broad spectrum and generating an output regarding the detected radiation;
a mounting device for positioning the light source and the one or more sensors approximately adjacent to the portion of tissue;
a processor for receiving the output from the sensors, the processor being configured for performing orthogonal analysis using weighting functions to determine the concentration of one or more blood analytes in the blood of the portion of tissue using self calibration in which the ratio of blood analyte to a blood reference material is used; and
a display for displaying the concentration of the one or more blood analytes. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. An ambulatory system for the rapid and continuous, non-invasive measurement of the concentration of one or more blood analytes comprising a sensor module and a pocket monitor module, wherein the sensor module comprises:
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a light source for generating and transmitting infrared radiation to an ear lobe;
a focusing device for focusing the infrared radiation from the light source onto a measurement point on the ear lobe;
a filter for separating the infrared radiation into separate wavelengths;
one or more sensors for detecting infrared radiation transmitted or reflected from the measurement point and generating spectral data corresponding to the detected infrared radiation received;
a means for mounting the light source, the focusing device, the filter, and the one or more sensors on the ear lobe to facilitate the transmission of infrared radiation through the earlobe and to the one or more sensors;
a processor for receiving spectral data from the sensors, the processor being configured for performing orthogonal analysis to determine blood analyte concentration data using self calibration in which the ratio of one or more blood analytes to a blood reference material is used; and
a radio frequency transmitter for transmitting the blood analyte concentration data over a short distance; and
the pocket monitor module comprises;
a radio frequency receiver for obtaining blood analyte concentration data from the sensor module; and
a monitor for displaying the blood analyte concentration data. - View Dependent Claims (31)
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Specification