Metabolic calorimeter employing respiratory gas analysis

• US 6,899,683 B2
• Filed: 05/31/2002
• Issued: 05/31/2005
• Est. Priority Date: 08/02/1999
• Status: Expired due to Term

• Current Assignee: Microlife Medical Home Solutions Inc.
• Original Assignee: HealtheTech, Inc.
• Inventors: Weintraub, Jeffrey C., Barber, Theodore W., Lawrence, Craig M., Prachar, Timothy J., Mault, James R., Nason, Kevin S., Pearce, Edwin M. Jr.
• Primary Examiner(s): Jones, Mary Beth
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US10/161,505
• Publication Number:
  US 20030028120A1
• Time in Patent Office: 1,096 Days
• Field of Search: 600529-543, 73/233
• US Class Current: 600/531
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/0833 Measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: A61B 5/222 combined with detection or measurement of physiological parameters, e.g. heart rate
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

An indirect calorimeter for measuring the metabolic rate of a subject includes a disposable portion and a reusable portion. The disposable portion includes a respiratory connector configured to be supported in contact with the subject so as to pass inhaled and exhaled gases as the subject breathes. The disposable portion also includes a flow pathway operable to receive and pass inhaled and exhaled gases, having a first end in fluid communication with the respiratory connector and a second end in fluid communication with a source and sink for respiratory gases. The disposable portion is disposed within the reusable portion, which includes a flow meter, a component gas concentration sensor, and a computation unit. The flow meter generates a signal as a function of the instantaneous flow volume of respiratory gases passing through the flow pathway and the component gas concentration sensor generates a signal as a function of the instantaneous fraction of a predetermined component gas in the exhaled gases. The computation unit receives the electrical signals from the flow meter and the concentration sensor and calculates at least one respiratory parameter for the subject as the subject breathes through the calorimeter.

Claims

1. An indirect calorimeter, comprising:

a disposable portion having a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;

a flow pathway within said disposable portion operable to receive and pass said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases;

a reusable portion having a housing with a recess defined therein for receiving said disposable portion;

a flow meter within said housing configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;

a component gas concentration sensor within said housing operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and

a computation unit operable within said housing to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter.

2. The calorimeter according to claim 1, wherein said flow pathway includes an elongated flow tube through which said inhaled and exhaled gases flow and a chamber disposed between said flow tube and said first end.

3. The calorimeter according to claim 2, wherein said disposable portion is received in said recess in a direction perpendicular to said flow tube.

4. The calorimeter according to claim 2, wherein said chamber directs said inhaled gases into said flow tube from a plurality of radial directions to induce turbulence in said inhaled gases within said flow tube.

5. The calorimeter according to claim 1, wherein said concentration sensor is an oxygen sensor.

6. The calorimeter according to claim 5, wherein said oxygen sensor is a fluorescence quench oxygen sensor.

7. The calorimeter according to claim 1, wherein said flow meter includes an upper ultrasonic transducer and a lower ultrasonic transducer in fluid communication with said inhaled and exhaled gases passing through said flow pathway.

8. The calorimeter according to claim 7, wherein at least one of said upper ultrasonic transducer and said lower ultrasonic transducer includes a plurality of microscopic transducers arranged in an array.

9. The calorimeter according to claim 8, wherein said microscopic transducers measure temperature, pressure and humidity for correcting a gas flow rate due to corresponding effects of temperature, pressure and humidity.

10. The calorimeter according to claim 1, further comprising a communication means for communicating with a remote computing device.

11. The calorimeter according to claim 10, wherein said communications means is a radio frequency transceiver.

12. The calorimeter according to claim 1, wherein said computation unit includes a removable data storage device.

13. The calorimeter according to claim 1, wherein said at least one respiratory parameter is a resting metabolic rate, which is calculated from a measured volume of oxygen consumed by said subject and a measured amount of carbon dioxide produced by said subject.

14. The calorimeter according to claim 13, further comprising a carbon dioxide sensing means operable to generate electrical signals as a function of an amount of carbon dioxide in said exhaled gases.

15. The calorimeter according to claim 14, wherein said electrical signals from said carbon dioxide sensing means is used by said computation unit to calculate a respiratory quotient.

16. The calorimeter according to claim 13, wherein said concentration sensor is a combined fluorescent quench sensor for measuring a concentration of carbon dioxide and a concentration of oxygen in said inhaled and exhaled gases.

17. The calorimeter according to claim 1, wherein said reusable portion includes an engagement slot for receiving a corresponding engagement rail extending outwardly from said disposable portion and operatively securing said disposable portion to said reusable portion.

18. The calorimeter according to claim 1, wherein said reusable portion includes an identifying means for recognizing said disposable portion and calculating said at least one respiratory parameter if said disposable portion is identified by said identifying means.

19. The calorimeter according to claim 18, wherein said disposable portion includes an associated identification code that is transmitted to said computation unit of said reusable portion when said disposable portion is disposed within said reusable portion.

20. The calorimeter according to claim 1, wherein said housing has a semi-cylindrically shaped side wall, and said reusable portion includes a top cap enclosing an upper end of said side wall, a bottom cap enclosing a lower end of said side wall, and a front cap extending therebetween edges of said side wall.

21. The calorimeter according to claim 20, wherein said bottom cap includes an opening in fluid communication with a portion of said flow pathway for providing a sink for said inhaled and exhaled gases.

22. The calorimeter according to claim 20, wherein said front cap includes a display screen for communicating with said subject.

23. The calorimeter according to claim 1, wherein said flow pathway includes at least one change in flow direction for said inhaled and exhaled gases flowing through said flow pathway.

24. The calorimeter according to claim 23, wherein flowing of said inhaled and exhaled gases through said flow pathway is turbulent.

25. The calorimeter according to claim 1, further comprising:

a temperature sensor within said housing operable to generate an electrical signal representative of ambient temperature;

an ambient pressure sensor within said housing operable to generate an electrical signal representative of ambient pressure; and

a humidity sensor within said housing operable to generate an electrical signal representative of relative humidity,

wherein said computation unit is operable to receive said electrical signals from said flow meter, said temperature sensor, said ambient pressure sensor, said humidity sensor, and said concentration sensor and to calculate said at least one respiratory parameter.

26. The calorimeter according to claim 25, said temperature sensor senses ambient temperature and concentration sensor temperature.

27. The calorimeter according to claim 25, wherein said temperature sensor, said ambient pressure sensor, and said humidity sensor are microscopic temperature, pressure and humidity transducers arranged in an array within said flow meter.

28. The calorimeter according to claim 1, further comprising a temperature sensing means, a pressure sensing means and a humidity sensing means for use by said computation unit in calculating said at least one respiratory parameter.

29. An indirect calorimeter, comprising:

a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases within a portion of a flow pathway as said subject breathes;

a disposable portion operatively connected to said respiratory connector and forming another portion of said flow pathway for receiving and passing said inhaled and exhaled gases, said another portion of said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, wherein said flow pathway includes an outer shell with a flow tube disposed within said outer shell and an annular flange interconnecting said flow tube and said outer shell so as to define a concentric chamber above said flange and between an outer surface of said flow tube and an inner surface of said outer shell;

a reusable portion having a housing with a recess defined therein for receiving said disposable portion;

a flow meter within said housing configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;

a component gas concentration sensor within said housing operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and

a computation unit operable within said housing to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter.

30. The calorimeter according to claim 29, further comprising an inlet conduit extending outwardly from said outer shell for receiving said respiratory connector, wherein said inlet conduit is in fluid communication with said concentric chamber.

31. The calorimeter according to claim 29, wherein said reusable portion includes an engagement slot for receiving a corresponding engagement rail extending outwardly from said disposable portion and or operatively securing said disposable portion to said reusable portion.

32. The calorimeter according to claim 29, wherein said reusable portion includes an identifying means for recognizing said disposable portion and calculating said at least one respiratory parameter if said disposable portion is identified by said identifying means.

33. The calorimeter according to claim 32, wherein said disposable portion includes an associated identification code that is transmitted to said computation unit of said reusable portion when said disposable portion is disposed within said reusable portion.

34. The calorimeter according to claim 29, wherein said housing has a semi-cylindrically shaped side wall, and said reusable portion includes a top cap enclosing an upper end of said side wall, a bottom cap enclosing a lower end of said side wall, and a front cap extending therebetween edges of said side wall.

35. The calorimeter according to claim 34, wherein said bottom cap includes an opening in fluid communication with said flow pathway for providing a sink for said inhaled and exhaled gases.

36. The calorimeter according to claim 34, wherein said front cap includes a display screen for communicating with said subject.

37. The calorimeter according to claim 29, wherein said flow pathway includes at least one change in flow direction for said inhaled and exhaled gases flowing through said flow pathway.

38. The calorimeter according to claim 37, wherein flowing of said inhaled and exhaled gases through said flow tube is turbulent.

39. The calorimeter according to claim 29, wherein said concentric chamber directs said inhaled gases into said flow tube from a plurality of radial directions to induce turbulence in said inhaled gases within said flow tube.

40. The calorimeter according to claim 29, wherein said concentration sensor is an oxygen sensor.

41. The calorimeter according to claim 40, wherein said oxygen sensor is a fluorescence quench oxygen sensor.

42. The calorimeter according to claim 29, further comprising a temperature sensing means, a pressure sensing means and a humidity sensing means for use by said computation unit in calculating said at least one respiratory parameter.

43. The calorimeter according to claim 29, wherein said flow meter includes an upper ultrasonic transducer and a lower ultrasonic transducer in fluid communication with said inhaled and exhaled gases passing through said flow pathway.

44. The calorimeter according to claim 29, further comprising a communication means for communicating with a remote computing device.

45. The calorimeter according to claim 29, wherein said at least one respiratory parameter is a resting metabolic rate, which is calculated from a measured volume of oxygen consumed by said subject and a measured amount of carbon dioxide produced by said the subject.

46. The calorimeter according to claim 45, further comprising a carbon dioxide sensing means operable to generate electrical signals as a function of an amount of carbon dioxide in said exhaled gases.

47. The calorimeter according to claim 46, wherein said electrical signals from said carbon dioxide sensing means is used by said the computation unit to calculate a respiratory quotient.

48. The calorimeter according to claim 45, wherein said concentration sensor is a combined fluorescent quench sensor for measuring a concentration of carbon dioxide and a concentration of oxygen in said inhaled and exhaled gases.

49. The calorimeter according to claim 29, further comprising:

a temperature sensor within said housing operable to generate an electrical signal representative of ambient temperature;

an ambient pressure sensor within said housing operable to generate an electrical signal representative of ambient pressure; and

a humidity sensor within said housing operable to generate an electrical signal representative of relative humidity,

wherein said computation unit is operable to receive said electrical signals from said flow meter, said temperature sensor, said ambient pressure sensor, said humidity sensor, and said concentration sensor and to calculate said at least one respiratory parameter.

50. The calorimeter according to claim 49, wherein said temperature sensor senses ambient temperature and concentration sensor temperature.

51. The calorimeter according to claim 49, wherein said temperature sensor, said ambient pressure sensor, and said humidity sensor are microscopic temperature, pressure and humidity transducers arranged in an array within said flow meter.

74. The calorimeter according to claim 49, further comprising:

a temperature sensor within said reusable portion operable to generate an electrical signal representative of ambient temperature;

an ambient pressure sensor within said reusable portion operable to generate an electrical signal representative of ambient pressure; and

a humidity sensor within said reusable portion operable to generate an electrical signal representative of relative humidity,

wherein said computation unit is operable to receive said electrical signals from said flow meter, said temperature sensor, said ambient pressure sensor, said humidity sensor, and said concentration sensor and to calculate said at least one respiratory parameter.

75. The calorimeter according to claim 74, wherein said temperature sensor senses ambient temperature and concentration sensor temperature.

76. The calorimeter according to claim 74, wherein said temperature sensor, said ambient pressure sensor, and said humidity sensor are microscopic temperature, pressure and humidity transducers arranged in an array within said flow meter.

52. An indirect calorimeter, comprising:

a disposable portion having a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;

a flow pathway within said disposable portion operable to receive and pass said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway comprising;

(1) a flow tube through which said inhaled and exhaled gases pass, (2) an outer housing surrounding said flow tube, (3) a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer housing, and (4) an outlet passage disposed between said flow tube and said second end;

a reusable portion operatively connected to said disposable portion;

a flow meter within said reusable portion configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;

a component gas concentration sensor within said reusable portion operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway, said concentration sensor being in fluid communication with said outlet passage; and

a computation unit within said reusable portion operable to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter.

53. The calorimeter according to claim 52, wherein said disposable portion is received in a recess in a direction perpendicular to said flow tube, said recess being defined within said reusable portion.

54. The calorimeter according to claim 52, further comprising:

a temperature sensor within said reusable portion operable to generate an electrical signal representative of ambient temperature;

an ambient pressure sensor within said reusable portion operable to generate an electrical signal representative of ambient pressure; and

a humidity sensor within said reusable portion operable to generate an electrical signal representative of relative humidity,

wherein said computation unit is operable to receive said electrical signals from said flow meter, said temperature sensor, said ambient pressure sensor, said humidity sensor, and said concentration sensor and to calculate said at least one respiratory parameter.

55. The calorimeter according to claim 54, wherein said temperature sensor senses ambient temperature and concentration sensor temperature.

56. The calorimeter according to claim 54, wherein said temperature sensor, said ambient pressure sensor, and said humidity sensor are microscopic temperature, pressure and humidity transducers arranged in an array within said flow meter.

57. An indirect calorimeter, comprising:

a disposable portion having a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes, wherein said disposable portion includes an outer shell having a ceiling at an upper end, a floor at a lower end and having an opening, and a rearward wall extending therebetween said ceiling and said floor and having an opening;

a flow pathway within said disposable portion operable to receive and pass said inhaled and exhaled gases, wherein said flow pathway includes a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for said inhaled and exhaled gases through said opening in said floor;

a flow tube within said flow pathway through which said inhaled and exhaled gases pass; and

a chamber disposed between said flow tube and said outer shell, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer shell;

an upper ultrasonic transducer mounted to a lower side of said ceiling in alignment with an upper end of said flow tube and a lower ultrasonic transducer mounted to an upper side of said floor in alignment with a lower end of said flow tube, wherein said upper ultrasonic transducer and said lower ultrasonic transducer generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gasses passing through said flow pathway;

a reusable portion operatively attached to said disposable portion, wherein said reusable portion includes a housing having a passageway in fluid communication with said source and sink for said inhaled and exhaled gases;

a component gas concentration sensor disposed within said housing in alignment with said opening in said rearward wall of said disposable portion and operable to generate an electrical signal as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and

a computation unit disposed within said housing operable to receive said electrical signals from said ultrasonic transducers and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter.

58. The calorimeter according to claim 57, wherein said concentration sensor is an oxygen sensor.

59. The calorimeter according to claim 57, wherein said concentration sensor is a fluorescence quench oxygen sensor having a fluorescence portion disposed in said rearward wall of said disposable portion and a sensing portion disposed in said reusable portion, wherein said fluorescence portion includes a light pipe with a fluorescent material positioned on said light pipe that is in contact with said inhaled and exhaled gasses passing through said flow pathway, and said light pipe conducts light traveling to and from said fluorescent material to said sensing portion.

60. The calorimeter according to claim 57, further comprising a temperature sensing means, a pressure sensing means and a humidity sensing means for use by said computation unit in calculating said at least one respiratory parameter.

61. The calorimeter according to claim 57, wherein said opening in said floor of said disposable portion is in alignment with said passageway in said reusable portion in fluid communication with said source and sink for said inhaled and exhaled gases.

62. An indirect calorimeter, comprising:

a disposable portion having a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;

wherein said disposable portion includes an outer shell having a ceiling at an upper end, a floor at a lower end, and a rearward wall extending therebetween said ceiling and said floor, said ceiling includes an opening with a pathogen resistant material disposed across said opening in said ceiling, said floor includes a first opening with another pathogen resistant material disposed across said first opening and a second opening, and said rearward wall includes an opening with another pathogen resistant material disposed across said opening in said rearward wall;

a flow pathway within said disposable portion operable to receive and pass said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway including a flow tube through which said inhaled and exhaled gases pass and a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer shell;

a reusable portion operatively attached to said disposable portion and having a passageway in fluid communication with said source and sink for respiratory gases and in alignment with said second opening in said floor;

a flow meter within said disposable portion, wherein said flow meter includes an upper ultrasonic transducer in alignment with said opening in said ceiling and a lower ultrasonic in alignment with said first opening in said the floor;

a component gas concentration sensor within said disposable portion in alignment with said said opening in said rearward wall; and

a computation unit within one of said disposable portion and said reusable portion, wherein said flow meter generates an electrical signal as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway, said concentration sensor generates an electrical signal as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway, and said computation unit receives said electrical signals from said flow meter and said concentration sensor and calculates at least one respiratory parameter for said subject as said subject breathes through said calorimeter.

63. The calorimeter according to claim 62, wherein said passageway is coated with an anti-viral material.

64. The calorimeter according to claim 62, further comprising a disposable sleeve contained within said passageway.

65. The calorimeter according to claim 62, wherein said passageway is coated with an anti-bacterial material.

66. The calorimeter according to claim 62, wherein said pathogen resistant material disposed across said opening in said rearward wall blocks passage of a predetermined pathogen from said exhaled gases while allowing passage of pulses from said concentration sensor.

67. The calorimeter according to claim 62, further comprising a temperature sensing means, a pressure sensing means and a humidity sensing means for use by said computation unit in calculating said at least one respiratory parameter.

68. An indirect calorimeter, comprising:

a disposable portion having a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;

wherein said disposable portion includes an outer shell having a ceiling at an upper end, a floor at a lower end, and a rearward wall extending therebetween said ceiling and said floor, said ceiling includes an opening with a resistant material disposed across said opening in said ceiling, said floor includes a first opening with another pathogen resistant material disposed across said first opening; and

a second opening, and said rearward wall includes an opening with another pathogen resistant material disposed across said opening in said rearward wall;

a flow pathway within said disposable portion operable to receive and pass said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway including a flow tube through which said inhaled and exhaled gases pass and a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer shell; and

a reusable portion operatively attached to said disposable portion and having;

(1) a passageway in fluid communication with said source and sink for respiratory gases, (2) a flow meter, (3) a component gas concentration sensor, and (4) a computation unit;

wherein said flow meter generates an electrical signal as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway, said concentration sensor generates an electrical signal as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway, and said computation unit receives said electrical signals from said flow meter and said concentration sensor and calculates at least one respiratory parameter for said subject as said the subject breathes through said calorimeter.

69. The calorimeter according to claim 68, wherein said opening in said ceiling is in alignment with an upper ultrasonic transducer for measuring said instantaneous flow volume, said first opening in said floor is in alignment with a lower ultrasonic transducer for measuring said instantaneous flow volume, and said opening in said rearward wall is in alignment with said concentration sensor.

70. The calorimeter according to claim 69, wherein said second opening in said floor is in alignment with said passageway in fluid communication with said source and sink for respiratory gases.

71. The calorimeter according to claim 70, wherein said passageway is coated with an anti-bacterial material.

72. The calorimeter according to claim 70, wherein said passageway is coated with an anti-viral material.

73. The calorimeter according to claim 70, further comprising a disposable sleeve contained within said passageway.

77. The calorimeter according to claim 68, wherein said pathogen resistant material disposed across said opening in said rearward wall blocks passage of a predetermined pathogen from said exhaled gases while allowing passage of pulses from said concentration sensor.