Method for treating an allergic or inflammatory disease

• US 6,899,893 B2
• Filed: 04/17/2003
• Issued: 05/31/2005
• Est. Priority Date: 06/29/2000
• Status: Expired due to Fees

• Current Assignee: Bio-Oriented Technology Research Advancement Institution, Agricultural Research Organization, Volcani Center (Government of Israel)
• Original Assignee: Bio-Oriented Technology Research Advancement Institution, Agricultural Research Organization, Volcani Center (Government of Israel)
• Inventors: Kawamoto, Keiko, Tsuji, Kenkou, Yamamoto, Mari, Tachibana, Hirofumi
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): BERKO, RETFORD O
• Application Number:
  US10/417,254
• Publication Number:
  US 20030165558A1
• Time in Patent Office: 775 Days
• Field of Search: 424/439, 424/401, 424/70.1, 424/400
• US Class Current: 424/439
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

This invention is to provide an agent for therapy and prevention of allergic diseases which has no adverse action, shows a high safety even by administration for a long period and is able to be utilized to food and/or beverage, cosmetics, etc. which are used daily. To be specific, it provides antiallergic agent and anti-inflammatory agent characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient; a method for the addition of an antiallergic agent for oral administration or an anti-inflammatory agent for oral administration which is characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient to food and/or beverage for prevention, suppression and mitigation of allergic symptoms or inflammatory symptoms.

Claims

1. A method for treating an allergic or inflammatory disease comprising administering to a subject in need thereof an amount of purified strictinin or a methylated derivative thereof effective to treat said allergic or inflammatory disease.

2. The method of claim 1 comprising treating a subject having an allergic disease.

3. The method of claim 1 comprising treating a subject having an inflammatory disease.

4. The method of claim 1 that comprises administering purified strictinin.

5. The method of claim 1 that comprises administering an purified methylated derivative of strictinin.

6. The method of claim 1, wherein said purified strictinin or methylated derivative of strictinin is extracted from tea.

7. The method of claim 1 that comprises administering a dosage of strictinin or a methylated derivative thereof ranging from 5 to 100 mg/kg.

8. The method of claim 1 that comprises administering a dosage of strictinin or a methylated derivative thereof ranging from 10 to 50 mg/kg.

9. The method of claim 1, wherein said strictinin or methylated derivative of strictinin is administered orally.

10. The method of claim 1, wherein said strictinin or methylated derivative of strictinin is administered externally.

11. The method of claim 1 comprising administering a food comprising strictinin or a methylated derivative of strictinin.

12. The method of claim 1 comprising administering a beverage comprising strictinin or a methylated derivative of strictinin.

13. A method for purifying strictinin or a methylated derivative thereof from tea comprising:

(a) extracting tea leaves with an aqueous methanol or ethanol solution,

(b) extracting the aqueous methanol or ethanol solution obtained in (a) with an aqueous chloroform solution,

(c) extracting the aqueous phase from (b) with ethyl acetate,

(d) fractionating the ethyl acetate layer from (c) on an ODS column and

(e) recovering one or more fractions containing purified strictinin or a methylated derivative thereof.

14. A purified strictinin obtained by the method of claim 13.

15. A purified methylated derivative of strictinin obtained by the method of claim 13.