Inhibitors of proteasomal activity for stimulating bone growth

• US 6,902,721 B1
• Filed: 10/20/1999
• Issued: 06/07/2005
• Est. Priority Date: 07/10/1998
• Status: Expired due to Fees

• Current Assignee: Osteoscreen IP, LLC
• Original Assignee: OsteoScreen, Inc.
• Inventors: Rossini, Jorge G., Mundy, Gregory R., Garrett, I. Ross
• Primary Examiner(s): GITOMER, RALPH J
• Application Number:
  US09/421,545
• Time in Patent Office: 2,057 Days
• Field of Search: 424/49, 424/92, 435/29, 435/69.2, 514/12
• US Class Current: 424/49
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/351 not condensed with another ring
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/4015 having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/7042 Compounds having saccharide radicals and heterocyclic rings
• CPC Class Codes: A61K 38/05 Dipeptides
• CPC Class Codes: A61K 38/06 Tripeptides
• CPC Class Codes: A61K 38/07 Tetrapeptides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation, in subject where this is desirable.

Claims

1. A method to enhance bone formation in a vertebrate animal which method comprises administering to a vertebrate animal in need of such treatment an effective amount of a compound that inhibits proteasomal activity and said compound being selected from the group consisting of a peptidyl aldehyde, and epoxomicin, whereby bone formation is enhanced in said vertebrate animal.

2. The method of claim 1 wherein said vertebrate animal is characterized by a condition selected from the group consisting of osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, metastatic bone disease, osteolytic bone disease, and post-plastic surgery that benefits from bone healing.

3. The method of claim 1 which further comprises administering to said subject one or more agents that promote bone growth or that inhibit bone resorption.

4. The method of claim 3 wherein said agents are selected from the group consisting of bone morphogenetic factors, anti-resorptive agents, osteogenic factors, cartilage-derived morphogenetic proteins, growth hormones, estrogens, bisphosphonates, statins and differentiating factors.

5. The method of claim 1, wherein the compound is a peptidyl aldehyde.

6. The method of claim 1, wherein the compound is epoxomicin.

7. The method of claim 1, wherein the vertebrate animal is a human.

8. The method of claim 1, wherein the vertebrate animal is a non-human mammal.