Glucose measuring assembly with a hydrogel
First Claim
1. A collection assembly for use in a glucose sampling system and for electrochemical detection of an amount or concentration of glucose, said collection assembly comprising:
- a collection insert layer comprising a first hydrogel having a first surface and a second surface, said first hydrogel comprising;
polyethylene oxide present in an amount of about 5% to about 20% by weight based on the total weight of the hydrogel;
water in an amount of about 50% or more and about 95% or less based on the total weight of the hydrogel;
a chloride salt, wherein background electrical signal in the gel is less than approximately 200 nA;
a phosphate buffer in an amount sufficient to maintain a pH in the hydrogel in the range of 6 to 8;
an enzyme composition comprising glucose oxidase, said glucose oxidase present in an amount of from about 10 units to about 5,000 units per gram of the total weight of the hydrogel; and
a biocide comprising an undecylenate;
a mask layer comprising a material that is substantially impermeable to glucose and derivatives thereof, wherein the mask layer (i) has an inner face and an outer face and the inner face is positioned in facing relationship with the first surface of the first hydrogel and (ii) defines a first opening that exposes at least a portion of the first surface of the first hydrogel; and
a gel retaining layer comprising an inner face and an outer face wherein (i) the inner face is positioned in facing relationship with the second surface of the first hydrogel, and (ii) the gel retaining layer defines a first opening that exposes at least a portion of the second surface of the first hydrogel.
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Abstract
This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.
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Citations
19 Claims
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1. A collection assembly for use in a glucose sampling system and for electrochemical detection of an amount or concentration of glucose, said collection assembly comprising:
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a collection insert layer comprising a first hydrogel having a first surface and a second surface, said first hydrogel comprising;
polyethylene oxide present in an amount of about 5% to about 20% by weight based on the total weight of the hydrogel;
water in an amount of about 50% or more and about 95% or less based on the total weight of the hydrogel;
a chloride salt, wherein background electrical signal in the gel is less than approximately 200 nA;
a phosphate buffer in an amount sufficient to maintain a pH in the hydrogel in the range of 6 to 8;
an enzyme composition comprising glucose oxidase, said glucose oxidase present in an amount of from about 10 units to about 5,000 units per gram of the total weight of the hydrogel; and
a biocide comprising an undecylenate;
a mask layer comprising a material that is substantially impermeable to glucose and derivatives thereof, wherein the mask layer (i) has an inner face and an outer face and the inner face is positioned in facing relationship with the first surface of the first hydrogel and (ii) defines a first opening that exposes at least a portion of the first surface of the first hydrogel; and
a gel retaining layer comprising an inner face and an outer face wherein (i) the inner face is positioned in facing relationship with the second surface of the first hydrogel, and (ii) the gel retaining layer defines a first opening that exposes at least a portion of the second surface of the first hydrogel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification