Microdialysis probes and methods of use
First Claim
1. A microdialysis probe comprising:
- a semi-premeable membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said membrane portion is disposed on said distal end of said outer tube;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion such that imaging said guiding means provides information as to the location of said membrane portion when said probe is inserted into a medium.
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Abstract
The subject invention pertains to novel microdialysis probes having highly advantageous structural features, particularly for clinical applications. A microdialysis probe of the subject invention can be introduced into a biological tissue using insertion means such that the insertion means can the be completely dissociated from the biological tissue and the microdialysis probe. The microdialysis probes of the subject invention can further include guiding means composed of imageable material that may be used to guide the microdialysis probes to a target tissue using the appropriate sensing equipment. A further aspect of the subject invention relates to methods of using novel microdialysis probes to assess the presence or absence of a substance within biological tissue. The subject invention further relates to methods of using novel microdialysis probes to deliver a substance within biological tissue.
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Citations
81 Claims
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1. A microdialysis probe comprising:
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a semi-premeable membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said membrane portion is disposed on said distal end of said outer tube;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion such that imaging said guiding means provides information as to the location of said membrane portion when said probe is inserted into a medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 60, 61, 62, 63, 64)
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47. A microdialysis probe comprising:
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a semi-permeable membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said distal end of said outer tube is closed, and wherein said outer surface of said outer tube defines an aperture exposing said membrane portion;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion such that imaging said guiding means provides information as to the location of said membrane portion when said probe is inserted into a medium. - View Dependent Claims (65, 66, 67, 68, 69)
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48. A microdialysis probe comprising:
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a semi-premeable membrane portion;
an outer tube, wherein said outer tube has a proximal end and a distal end, and wherein said membrane portion is disposed on said distal end of said outer tube; and
an inner tube, wherein said inner tube is arranged within said outer tube, and wherein said inner tube comprises an imageable material. - View Dependent Claims (49, 50, 51, 52, 53, 54, 70, 71, 72, 73)
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55. A microdialysis probe comprising:
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a membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said membrane portion is disposed on said distal end of said outer tube;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said inner tube is arranged within said outer tube, and wherein said inner tube is semi-circular in cross-section;
and a guiding means located on said probe in a known spatial relationship with said membrane portion. - View Dependent Claims (74, 75, 76, 77)
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56. A microdialysis probe comprising:
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a membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said membrane portion is disposed on said distal end of said outer tube;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion, wherein said membrane portion has a closed distal end and a proximal end having an opening, wherein said proximal end of said membrane portion is attached to said distal end of said outer tube, wherein said guiding means comprises a first ring member and a second ring member, and wherein said first ring member is located on or adjacent to said proximal end of said membrane portion and wherein said second ring member is located on or adjacent to said distal end of said membrane portion. - View Dependent Claims (57, 58, 59, 78, 79, 80, 81)
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Specification