Modification of selectivity for sensing for nanostructure device arrays

• US 6,905,655 B2
• Filed: 03/14/2003
• Issued: 06/14/2005
• Est. Priority Date: 03/15/2002
• Status: Expired due to Fees

• Current Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Original Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Inventors: Collins, Philip G., Bradley, Keith, Gruner, George, Gabriel, Jean-Christophe P.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): SINES, BRIAN J
• Application Number:
  US10/388,701
• Publication Number:
  US 20030175161A1
• Time in Patent Office: 823 Days
• Field of Search: 422/50, 422/55, 422/56, 422/57, 422/58, 422/68.1, 422/69, 422/88, 422/82.01, 422/82.02, 422/83, 422/90, 422/98, 436/43, 436/63, 436/64, 436/65, 436/66, 436/68, 436/71, 436/73, 436/74, 436/75, 436/149, 436/150, 436/151, 204/193, 204/194, 204/400, 204/403.01, 204/403.03, 204/403.13, 204/406, 204/407, 73/10.1, 73/10.2, 73/190.1, 73/232, 73/530.1, 438/48, 438/49
• US Class Current: 422/82.01
• CPC Class Codes: B01J 2219/00653 the compounds being bound to electrodes embedded in or on the solid supports
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 27/126 comprising organic polymers
• CPC Class Codes: G01N 27/127 comprising nanoparticles
• CPC Class Codes: Y10S 977/84 Manufacture, treatment, or detection of nanostructure
• CPC Class Codes: Y10S 977/855 for manufacture of nanostructure
• CPC Class Codes: Y10S 977/882 Assembling of separate components, e.g. by attaching
• CPC Class Codes: Y10S 977/92 Detection of biochemical
• CPC Class Codes: Y10S 977/957 Of chemical property or presence
• CPC Class Codes: Y10S 977/958 Of biomolecule property
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifiying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided. The methods involve comparing signals from nanostructure sensing devices that have not been exposed to the chemical species of interest with signals from nanostructure sensing devices that have been exposed to the chemical species of interest. Nanostructure sensing device array structures that can measure and subtract out environmental factors are also disclosed.

Claims

1. An electronic system for selectively detecting and identifying a plurality of chemical or biological species, comprising:

an array of nanostructure sensing devices containing;

a first nanostructure sensing device comprising a first nanostructure, at least two contact electrodes electrically connected by the first nanostructure and a protective coating on the contact electrodes, the first nanostructure sensing device having a selectivity for sensing a first species;

a second nanostructure sensing device comprising a second nanostructure, at least two contact electrodes electrically connected by the second nanostructure and a protective coating on the contact electrodes, the second nanostructure sensing device having a selectivity for sensing a second species; and

a processing system to deconvolute and analyze signals from the array to provide identification of chemical or biological species.

2. The electronic system of claim 1, wherein the contact electrodes comprise a material selected from the group consisting of aluminum, copper, titanium and tungsten.

3. The electronic system of claim 1, wherein the protective coating is selected from the group consisting of silicon oxides, metal oxides, polymer films, and nonvolatile organics.

4. The electronic system of claim 1, further comprising a gate electrode in the first nanostructure sensing device.

5. The electronic system of claim 1, further comprising a counter electrode, electrically isolated from the contact electrodes, in the first nanostructure sensing device.

6. The electronic system of claim 5, further comprising a pseudo-reference electrode, electrically isolated from the contact electrodes, in the first nanostructure sensing device.

7. The electronic system of claim 1, wherein the first nanostructure and the second nanostructure are selected from the group consisting of single-walled nanotubes, multi-walled nanotubes, nanofibers, nanowires, nanocoils, nanospheres, nanocages, nanococoons, nanohorns, nanoropes, nanotori, nanorods, nanoplatelets, and other extended molecules such as polymers, dendrimers, organometallics, fullerene-like molecules, and combinations thereof.

8. The electronic system of claim 1, wherein the first nanostructure and the second nanostructure have approximately linear forms.

9. The electronic system of claim 1, wherein the first nanostructure and the second nanostructure comprise elements selected from the group consisting of boron, carbon, combinations thereof, and combinations with nitrogen.

10. The electronic system of claim 1, further comprising third and fourth nanostructure sensing devices having the same selectivity for sensing as the first nanostructure sensing device, wherein the first nanostructure sensing device is at least partially exposed to the plurality of species and to water, the third nanostructure sensing device is shielded from the plurality of species but not from water, and the fourth nanostructure sensing device is shielded from the plurality of species and from water.

11. The electronic system of claim 10, wherein the third nanostructure sensing device is shielded by a molecular sieve membrane.

12. The electronic system of claim 11, wherein the molecular sieve membrane contains an alumino silicate zeolite.

13. The electronic system of claim 1, further comprising third and fourth nanostructure sensing devices having the same selectivity for sensing as the first nanostructure sensing device, wherein the first nanostructure sensing device is at least partially exposed to the plurality of species and to water, the third nanostructure sensing device is at least partially exposed to the plurality of species but not to water, and the fourth nanostructure sensing device is shielded from the plurality of species and from water.

14. The electronic system of claim 13, wherein the third nanostructure sensing device contains a hydrophobic membrane.

15. The electronic system of claim 14, wherein the hydrophobic membrane contains a siliceous zeolite.

16. The electronic system of claim 14, wherein the hydrophobic membrane contains a fluoropolymer.

17. An electronic system for selectively detecting and identifying a plurality of chemical or biological species, comprising:

(a) an array of nanostructure sensing devices including;

a first nanostructure sensing device having a selectivity for sensing a first species, and comprising a first nanostructure and at least two contact electrodes, the contact electrodes electrically connected by the first nanostructure;

a second nanostructure sensing device having a selectivity for sensing a second species, and comprising a second nanostructure and at least two contact electrodes, the contact electrodes electrically connected by the second nanostructure;

at least one of the first and second nanostructure sensing devices further including a gate electrode; and

(b) a processing system to deconvolute and analyze signals from the array to provide identification of chemical or biological species.

18. The electronic system of claim 17, further comprising a protective coating on the contact electrodes.

19. The electronic system of claim 18 wherein the protective coating is selected from the group consisting of silicon oxides, metal oxides, polymer films, and nonvolatile organics.

20. The electronic system of claim 17, further comprising a counter electrode, electrically isolated from the contact electrodes, in the first nanostructure sensing device.

21. The electronic system of claim 20, further comprising a pseudo-reference electrode, electrically isolated from the contact electrodes, in the first nanostructure sensing device.

22. The electronic system of claim 17, wherein the first nanostructure and the second nanostructure are selected from the group consisting of single-walled nanotubes, multi-walled nanotubes, nanofibers, nanowires, nanocoils, nanospheres, nanocages, nanococoons, nanohorns, nanoropes, nanotori, nanorods, nanoplatelets, and other extended molecules such as polymers, dendrimers, organometallics, fullerene-like molecules, and combinations thereof.

23. The electronic system of claim 17, wherein the first nanostructure and the second nanostructure have approximately linear forms.

24. The electronic system of claim 17, wherein the first nanostructure and the second nanostructure comprise elements selected from the group consisting of boron, carbon, combinations thereof, and combinations with nitrogen.