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Methods for selectively stimulating proliferation of T cells

  • US 6,905,681 B1
  • Filed: 07/08/1999
  • Issued: 06/14/2005
  • Est. Priority Date: 06/03/1994
  • Status: Expired due to Fees
First Claim
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1. A method for including ex vivo proliferation of a population of T cells to sufficient numbers for use in therapy, comprising contacting a population of T cells ex vivo with a surface having directly attached thereon:

  • (a) an anti-CD3 antibody or CD3-binding fragment thereof, which provides a primary activation signal to the T cells, thereby activating the T cells; and

    (b) an anti-CD28 antibody or CD28-binding fragment thereof, which stimulates a CD28 accessory molecule on the surface of the T cells, thereby stimulating the activated T cells, wherein the anti-CD3 antibody or CD3-binding fragment thereof, and the anti-CD28 antibody or CD28-binding fragment thereof, are directly attached on the same surface, the anti-CD3 antibody or CD3-binding fragment thereof, and the anti-CD28 antibody or CD28-binding fragment thereof, thereby inducing the T cells to proliferate to sufficient numbers for use in therapy.

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