Particulate carrier for biocide formulations

• US 6,905,698 B1
• Filed: 08/24/1999
• Issued: 06/14/2005
• Est. Priority Date: 08/28/1998
• Status: Expired due to Fees

• Current Assignee: Ineos Silicas Limited (INEOS Holdings Ltd.)
• Original Assignee: Ineos Silicas Limited (INEOS Holdings Ltd.)
• Inventors: Robinson, Julie, Turner, Dafydd, Edge, Michel, Seal, Kenneth, Jones, Helen, Aldcroft, Derek
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US09/763,916
• Time in Patent Office: 2,121 Days
• Field of Search: 424/405, 424/407, 424/421, 424/724, 424/682, 424/409, 514/372
• US Class Current: 424/405
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 43/80 five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• CPC Class Codes: C09D 5/14 Paints containing biocides, e.g. fungicides, insecticides or pesticides C09D5/16 takes precedence

Abstract

A particulate carrier material is impregnated with a biocidal formulation and serves as a vehicle for introduction of the biocide into a liquid-based media, such as a surface coating or surface cleaning compositions, in order to allow controlled release of the biocide to combat bacterial, fungal, algal or like growth for an extend period of time.

Claims

1. A particulate composition of matter comprising a liquid dispersible mass of porous inorganic carrier particles which is at least one of amorphous silicas, amorphous aluminas, pseudoboehmites, Y-zeolites, dealuminated Y-zeolites or mixtures of two or more thereof and biocide releasably adsorbed within the pore system thereof, said particles having a retention factor R, determined from the equation R=A/P, where A represents the percentage active ingredient by weight remaining in the pore system after contacting a sample consisting of a homogenised mixture of 0.75 g biocide and 2.25 g of carrier particles with 1000 ml of water for 90 minutes and P represents the potency as defined by the Minimum Inhibition Concentration in mg of active ingredient per liter of the biocide determined with respect to the reference microorganism Aureobasidium pullulans, of at least 0.6, and a BET surface area of at least 200 m² g, wherein the biocide is at least one of 2-methyl-4-isothiazolone, 2-ethyl-4-isothiazolin-3-one, 2-propyl-4-isothiazolin-3-one, 2-butyl-4-isothiazolin-3-one, 2-amyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 5-bromo-2-methyl-4-isothiazolin-3-one, 5-iodo-2-methyl-4-isothiazolin-3-one, 5-chloro-2-butyl-4-isothiazolin-3-one, 5-bromo-2-ethyl-4-isothiazolin-3-one, 5-iodo-2-amyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one, or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one.

2. A composition as claimed in claim 1 in which the retention factor is at least 0.8.

3. A composition as claimed in claim 1 in which the particles carry at least 30% by weight of biocide solution.

4. A composition as claimed in claim 1 in which the particles have an activated micropore system.

5. A composition as claimed in claim 1 in which the particles have a BET surface area of at least 300 m²/g.

6. A composition as claimed in claim 1 in which the particles have a biocide adsorption capacity of at least 10% by weight.

7. A liquid-based medium incorporating the particulate composition as claimed in claim 1, said liquid medium comprising a surface coating composition, a surface cleaning composition, a sealant composition, a tiling composition, a grouting composition or a drilling mud.

8. A liquid-based medium incorporating the particulate composition as claimed in claim 3, said liquid medium comprising a surface coating composition, a surface cleaning composition, a sealant composition, a tiling composition, a grouting composition and a drilling mud.

9. A surface coating formulation as claimed in claim 1 in the form of a water-based or organic solvent-based paint.

10. A composition as claimed in claim 1 in which the particles have:

a weight mean particle size less than 50 microns.

11. The composition of claim 1 wherein said particles have a pore area of at least 25 m²/g.

12. A particulate composition of matter comprising a liquid dispersible mass of porous inorganic carrier particles which are Y-zeolites with, optionally, amorphous silicas, dealuminated Y-zeolites, or mixtures of two or more of these and biocide releasably adsorbed within the pore system thereof, said particles having a retention factor R, determined from the equation R=A/P, where A represents the percentage active ingredient by weight remaining in the pore system after contacting a sample consisting of a homogenised mixture of 0.75 g biocide and 2.25 g of carrier particles with 1000 ml of water for 90 minutes and P represents the potency as defined by the Minimum Inhibition Concentration in mg of active ingredient per liter of the biocide determined with respect to the reference microorganism Aureobasidium pullulans, of at least 0.6, and a BET surface area of at least 200 m²/g, wherein the biocide is at least one of 2-methyl-4-isothiazolone, 2-ethyl-4-isothiazolin-3-one, 2-propyl-4-isothiazolin-3-one, 2-butyl-4-isothiazolin-3-one, 2-amyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 5-bromo-2-methyl-4-isothiazolin-3-one, 5-iodo-2-methyl-4-isothiazolin-3-one, 5-chloro-2-butyl-4-isothiazolin-3-one, 5-bromo-2-ethyl-4-isothiazolin-3-one, 5-iodo-2-amyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one, or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one.

13. A particulate composition of matter comprising a liquid dispersible mass of porous inorganic carrier particles which are dealuminated Y-zeolites with, optionally, amorphous silicas, Y-zeolites, or mixtures of two or more of these and biocide releasably adsorbed within the pore system thereof, said particles having a retention factor R, determined from the equation R=A/P, where A represents the percentage active ingredient by weight remaining in the pore system after contacting a sample consisting of a homogenised mixture of 0.75 g biocide and 2.25 g of carrier particles with 1000 ml of water for 90 minutes and P represents the potency as defined by the Minimum Inhibition Concentration in mg of active ingredient per liter of the biocide determined with respect to the reference microorganism Aureobasidium pullulans, of at least 0.6, and a BET surface area of at least 200 m²/g, wherein the biocide is at least one of 2-methyl-4-isothiazolone, 2-ethyl-4-isothiazolin-3-one, 2-propyl-4-isothiazolin-3-one, 2-butyl-4-isothiazolin-3-one, 2-amyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 5-bromo-2-methyl-4-isothiazolin-3-one, 5-iodo-2-methyl-4-isothiazolin-3-one, 5-chloro-2-butyl-4-isothiazolin-3-one, 5-bromo-2-ethyl-4-isothiazolin-3-one, 5-iodo-2-amyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one, or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one.

14. A particulate composition of matter useful as a vehicle for introducing biocide into a liquid-based medium comprising a liquid-dispersible mass of inorganic carrier particles comprising Y zeolite particles having biocide adsorbed within the pore system thereof for release of biocide into the liquid medium, said amorphous Y zeolite particles having a retention factor R, determined from the equation R=A/P, where A represents the percentage active ingredient by weight remaining in the pore system after contacting a sample consisting of a homogenised mixture of 0.75 g biocide and 2.25 g of carrier particles with 1000 ml of water for 90 minutes and P represents the potency as defined by the Minimum Inhibition Concentration in mg of active ingredient per liter of the biocide determined with respect to the reference microorganism Aureobasidium pullulans, of at least 0.6, and wherein the biocide is at least one of 2-methyl-4-isothiazolone, 2-ethyl-4-isothiazolin-3-one, 2-propyl-4-isothiazolin-3-one, 2-butyl-4-isothiazolin-3-one, 2-amyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 5-bromo-2-methyl-4-isothiazolin-3-one, 5-iodo-2-methyl-4-isothiazolin-3-one, 5-chloro-2-butyl-4-isothiazolin-3-one, 5-bromo-2-ethyl-4-isothiazolin-3-one, 5-iodo-2-amyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one, or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one.

15. A composition as claimed in claim 14 in which the Y zeolite is a dealuminated Y zeolite.

16. A composition as claimed in claim 14 in which the Si:

Al ratio of the Y zeolite is at least about 5;

1.

17. A composition as claimed in claim 14 in which the Si:

Al ratio of the Y zeolite is in the range from about 5;

1 to about 33;

1.

18. A composition as claimed in claim 14 in which the retention factor is at least 0.8.

19. A composition as claimed in claim 14 in which the particles carry at least 30% by weight of biocide solution.

20. A composition as claimed in claim 14 in which the particles have an activated micropore system.

21. A composition as claimed in claim 14 in which the particles have a biocide adsorption capacity of at least 10% by weight.

22. A liquid-based medium incorporating the particulate composition as claimed in claim 14, said liquid medium comprising a surface coating composition, a surface cleaning composition, a sealant composition, a tiling composition, a grouting composition or a drilling mud.

23. A liquid-based medium incorporating the particulate composition as claimed in claim 19, said liquid medium comprising a surface coating composition, a surface cleaning composition, a sealant composition, a tiling composition, a grouting composition and a drilling mud.

24. A surface coating formulation as claimed in claim 14 in the form of a water-based or organic solvent-based paint.

25. A composition as claimed in claim 14 in which the particles have a weight mean particle size less than 50 microns.

26. The composition of claim 14 wherein said particles have a pore area of at least 25 m² μ

g.

27. A particulate composition of matter useful as a vehicle for introducing biocide into a liquid-based medium comprising a liquid-dispersible mass of inorganic carrier particles having a pore size range including the range from about 20 to about 50 Angstroms;

and a pore area of at least 25 m²/g in the pore size range from about 20 to about 50 Angstroms and comprising Y zeolite particles having biocide adsorbed within the pore system thereof for release of biocide into the liquid medium, said amorphous Y zeolite particles having a retention factor R, determined from the equation R=A/P, where A represents the percentage active ingredient by weight remaining in the pore system after contacting a sample consisting of a homogenised mixture of 0.75 g biocide and 2.25 g of carrier particles with 1000 ml of water for 90 minutes and P represents the potency as defined by the Minimum Inhibition Concentration in mg of active ingredient per liter of the biocide determined with respect to the reference microorganism Aureobasidium pullulans, of at least 0.6.

28. A composition as claimed in claim 27 in which the retention factor is at least 0.8.

29. A composition as claimed in claim 27 in which the particles carry at least 30% by weight of biocide solution.

30. A composition as claimed in claim 27 in which the particles have an activated micropore system.

31. A composition as claimed in claim 27 in which the particles have a biocide adsorption capacity of at least 10% by weight.

32. A liquid-based medium incorporating the particulate composition as claimed in claim 27, said liquid medium comprising a surface coating composition, a surface cleaning composition, a sealant composition, a tiling composition, a grouting composition or a drilling mud.

33. A liquid-based medium incorporating the particulate composition as claimed in claim 30, said liquid medium comprising a surface coating composition, a surface cleaning composition, a sealant composition, a tiling composition, a grouting composition and a drilling mud.

34. A surface coating formulation as claimed in claim 27 in the form of a water-based or organic solvent-based paint.

35. A composition as claimed in claim 27 in which the particles have a weight mean particle size less than 50 microns.

36. A composition as claimed in claim 27 in which the Y zeolite is a dealuminated Y zeolite.

37. A composition as claimed in claim 27 in which the Si:

Al ratio of the Y zeolite is at least about 5;

1.

38. A composition as claimed in claim 27 in which the Si:

Al ratio of the Y zeolite is in the range from about 5;

1 to about 33;

1.