Human cervical cancer 2 protooncogene and protein encoded therein

• US 6,905,844 B2
• Filed: 07/09/2001
• Issued: 06/14/2005
• Est. Priority Date: 11/28/2000
• Status: Expired due to Fees

• Current Assignee: Jin-Woo Kim
• Original Assignee: Jin-Woo Kim
• Inventors: Kim, Jin-Woo
• Primary Examiner(s): Ungar, Susan
• Assistant Examiner(s): DAVIS, MINH TAM B
• Application Number:
  US10/432,803
• Publication Number:
  US 20040029199A1
• Time in Patent Office: 1,436 Days
• Field of Search: 435/6, 435/69.1, 435/252.3, 435/320.1, 536/23.1, 536/23.5, 536/24.3, 536/24.31, 514/44
• US Class Current: 435/69.1
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/82 Translation products from oncogenes

Abstract

A human cervical cancer 2 protooncogene having a base sequence of SEQ ID: 1 or a fragment thereof is overexpressed in various cancer tissues and can be used in diagnosing various cancers and an anti-sense gene complementary thereto can be used in treating cancers.

Claims

1. A human cervical cancer 2 protooncogene having the nucleotide sequence of SEQ ID NO:

1.

3. A vector comprising the protooncogene of claim 1.

4. A microorganism transformed with the vector of claim 3.

5. The microorganism of claim 4, which is E. coli JM109/HCCR2(Accession NO:

KCTC 0668BP).

6. A process for preparing a protein having the amino acid sequence of SEQ ID NO:

2 comprising the step of culturing the microorganism of claim 4.

7. A kit for diagnosis of cancer which comprises the protooncogene of claim 1.

8. A process for preparing a protein having the amino acid sequence of SEQ ID NO:

2 comprising culturing the microorganism of claim 5.

2. A human cervical cancer 2 protooncogene having the nucleotide sequence comprising nucleotides Nos. 63 to 977 of SEQ ID NO:

1 and encoding the amino acid sequence of SEQ ID NO;

2.

9. A kit for diagnosing cancer which comprises the protooncogene of claim 2.

10. A vector comprising the protooncogene of claim 2.

11. A microorganism transformed with the vector of claim 10.

12. A process for preparing a protein having the amino acid sequence of SEQ ID NO:

2 comprising culturing the microorganism of claim 11.