Cardiac rhythm management system adjusting rate response factor for treating hypotension
First Claim
Patent Images
1. A method including:
- detecting a thoracic impedance signal associated with a portion of a subject'"'"'s thorax; and
providing a therapy to the subject'"'"'s heart at least in part in response to a baseline portion of the detected thoracic impedance below about 0.5 Hz indicating a fluid shift away from the thorax, the therapy assisting to shift fluid back toward the thorax, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output.
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Abstract
A cardiac rhythm management system detects hypotension, such as by using thoracic impedance to detect a fluid shift away from the thorax. In response to an episode of detected hypotension, it increases a pacing rate response factor mapping a metabolic need to an indicated pacing rate provided by the system. The metabolic need is indicated by an accelerometer, a respiration sensor, or other metabolic need sensor indicating a subject'"'"'s need for adjusting cardiac output.
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Citations
34 Claims
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1. A method including:
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detecting a thoracic impedance signal associated with a portion of a subject'"'"'s thorax; and
providing a therapy to the subject'"'"'s heart at least in part in response to a baseline portion of the detected thoracic impedance below about 0.5 Hz indicating a fluid shift away from the thorax, the therapy assisting to shift fluid back toward the thorax, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output. - View Dependent Claims (2)
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3. A method including:
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detecting a thoracic impedance signal associated with a portion of a subject'"'"'s thorax; and
providing a therapy to the subject'"'"'s heart at least in part in response to the detected thoracic impedance, including increasing a rate of pacing stimuli at least in part in response to an increase in the baseline portion of the thoracic impedance below about 0.5 Hz indicating a fluid shift away from the thorax, the therapy assisting to shift fluid back toward the thorax, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method including:
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detecting a change in a thoracic impedance signal associated with a subject'"'"'s thorax and including a thoracic fluid shift signal having a frequency component that is less than or equal to a cutoff frequency value that is between 0.01 Hz and 0.5 Hz inclusive; and
increasing a rate of delivery of pacing stimuli at least in part in response to a detected increase in a baseline portion of the thoracic impedance signal indicating a fluid shift away from the thorax, the therapy assisting to shift fluid back toward the thorax and thereby decreasing the baseline portion of the thoracic impedance signal, the increasing the rate of delivery of pacing stimuli, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output. - View Dependent Claims (14, 15, 16)
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17. A method including:
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detecting, using an implantable medical device to indicate thoracic hypotension resulting from a fluid shift away from the thorax using transthoracic impedance below about 0.5 Hz to indicate how much fluid is present in a thorax, both a hypotension associated with a change in a subject'"'"'s posture and a hypotension that is not associated with a change in the subject'"'"'s posture; and
providing a therapy to the subject'"'"'s heart at least in part in response to the detected hypotension, the therapy assisting to shift fluid back toward the thorax to reduce the hypotension, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output. - View Dependent Claims (18)
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19. A cardiac rhythm management system, including:
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first and second electrodes configured for association with a portion of a subject'"'"'s thorax;
a thoracic signal detection module, coupled to the first and second electrodes for receiving a thoracic impedance signal and including an averager/lowpass filter that obtains a baseline portion of the thoracic impedance signal below about 0.5 Hz that is associated with a fluid shift away from the thorax; and
means for performing a function of providing therapy to the subject'"'"'s heart based on the baseline portion of the thoracic impedance signal, the therapy assisting to shift fluid back toward the thorax, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output.
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20. A cardiac rhythm management system, including:
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first and second electrodes configured for association with a portion of a subject'"'"'s thorax;
a thoracic signal detection module, coupled to the first and second electrodes for receiving a thoracic impedance signal and including an averager/lowpass filter that obtains a baseline portion of the thoracic impedance signal below about 0.5 Hz that is associated with a fluid shift away from the thorax; and
a pacing therapy output circuit providing therapy to the subject'"'"'s heart in response to the baseline portion of the thoracic impedance signal indicating a fluid shift away from the thorax, the therapy assisting to shift fluid back toward the thorax, the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output.
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21. A cardiac rhythm management system, including:
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first and second electrodes configured for association with a portion of a subject'"'"'s thorax;
means, coupled to the first and second electrodes for receiving a thoracic impedance signal, for performing the function of obtaining a baseline portion of the thoracic impedance signal below about 0.5 Hz that is associated with a fluid shift away from the thorax; and
a pacing therapy output circuit providing therapy to the subject'"'"'s heart in response to the baseline portion of the thoracic impedance signal indicating a fluid shift away from the thorax, the therapy assisting to shift fluid back toward the thorax, therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output.
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22. A cardiac rhythm management system, including:
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first and second electrodes configured for association with a portion of a subject'"'"'s thorax;
a thoracic signal detection module, coupled to the first and second electrodes;
third and fourth electrodes configured for association with a portion of a subject'"'"'s heart;
a pacing therapy output module, coupled to the third and fourth electrodes; and
a pacing stimuli rate controller, coupled to the thoracic signal detection module for receiving a thoracic impedance signal including a baseline signal component associated with a fluid shift away from the thorax, the controller also coupled to the pacing therapy output module for adjusting the rate of delivery of pacing stimuli at least in part in response to the portion of the thoracic impedance signal below about 0.5 Hz associated with the thoracic fluid shift away from the thorax, the adjusting the rate of delivery of pacing stimuli assisting to shift fluid back toward the thorax, the providing the therapy including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A cardiac rhythm management system, including:
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first and second electrodes configured for association with a portion of a subject'"'"'s thorax;
a thoracic signal detection module, coupled to the first and second electrodes;
thoracic test signal generator configured for association with the thorax for providing energy to the thorax for detecting thoracic impedance;
third and fourth electrodes configured for association with a portion of a subject'"'"'s heart;
a pacing therapy output module, coupled to the third and fourth electrodes; and
a pacing stimuli rate control module, coupled to the thoracic signal detection module for receiving a thoracic impedance signal, the rate control module including a lowpass filter for distinguishing a baseline thoracic fluid shift signal below about 0.5 Hz from another variation in thoracic impedance, the rate control module also coupled to the pacing therapy output module for adjusting the rate of delivery of pacing stimuli at least in part in response to the thoracic fluid shift signal indicating a fluid shift away from the thorax, the adjusting the rate of delivery of pacing stimuli assisting to shift fluid back toward the thorax, the adjusting the rate of delivery including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output.
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34. A cardiac rhythm management system, including:
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means for detecting a thoracic impedance;
first and second electrodes, configured for association with a portion of a subject'"'"'s heart;
a pacing therapy output module, coupled to the first and second electrodes; and
a pacing stimuli rate control module, coupled to the means for detecting thoracic impedance and the pacing therapy output module, the rate control module adjusting a rate of delivery of pacing stimuli at least in part in response to a baseline portion of the thoracic impedance below about 0.5 Hz indicating a thoracic fluid shift away from the thorax, the adjusting the rate of delivery of pacing stimuli assisting to shift fluid back toward the thorax, the adjusting the rate of delivery including adjusting a rate response factor defining a relationship between (a) a pacing rate at which stimulations are delivered to the subject'"'"'s heart; and
(b) an activity level or respiration sensor signal that is correlative to the subject'"'"'s metabolic need for cardiac output.
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Specification