Methods and apparatus for analyzing polynucleotide sequences
First Claim
Patent Images
1. An apparatus for analyzing the sequence of a polynucleotide, comprising:
- (a) a flow cell comprising at least one synthesis channel coated with a polyelectrolyte multilayer;
(b) an inlet port and an outlet port in a fluid communication with said flow cell for flowing fluids into and through said flow cell and said at least one synthesis channel; and
(c) at least one polynucleotide attached to said polyelectrolyte multilayer, wherein said polyelectrolyte multilayer comprises alternating at least one polycation and at least one polyanion layers and wherein said at least one polynucleotide is attached to said polyanion layer.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides an apparatus for analyzing the sequences of polynucleotides. The apparatus comprises (a) flow cell which has at least one microfabricated multilayer elastomeric synthesis channel; and (b) an inlet port and an outlet port. The inlet port and outlet ports are in fluid communication with the flow cell for flowing fluids into and through the flow cell.
-
Citations
12 Claims
-
1. An apparatus for analyzing the sequence of a polynucleotide, comprising:
-
(a) a flow cell comprising at least one synthesis channel coated with a polyelectrolyte multilayer;
(b) an inlet port and an outlet port in a fluid communication with said flow cell for flowing fluids into and through said flow cell and said at least one synthesis channel; and
(c) at least one polynucleotide attached to said polyelectrolyte multilayer, wherein said polyelectrolyte multilayer comprises alternating at least one polycation and at least one polyanion layers and wherein said at least one polynucleotide is attached to said polyanion layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
Specification