Controlling resorption of bioresorbable medical implant material
First Claim
1. A medical device for use in a mammal comprising:
- (a) a bioresorbable bulk material comprising an ionically or covalently crosslinked polymeric material; and
(b) resorbable particles containing an agent that causes swelling of the particles upon contact with a body fluid, said particles embedded in said bioresorbable bulk material and said swelling of the particles causing fragmentation of said bioresorbable bulk material.
4 Assignments
0 Petitions
Accused Products
Abstract
The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.
133 Citations
35 Claims
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1. A medical device for use in a mammal comprising:
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(a) a bioresorbable bulk material comprising an ionically or covalently crosslinked polymeric material; and
(b) resorbable particles containing an agent that causes swelling of the particles upon contact with a body fluid, said particles embedded in said bioresorbable bulk material and said swelling of the particles causing fragmentation of said bioresorbable bulk material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 33, 34, 35)
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18. A method for controlling resorption of a bioresorbable material in a device for use in a mammal, said method comprising:
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(a) providing a bioresorbable bulk material comprising an ionically or covalently crosslinked polymeric material;
(b) embedding resorbable particles in said bioresorbable bulk material, said resorbable particles resorbing faster upon contact with a body fluid than said bioresorbable bulk material; and
(c) contacting a body fluid with said bioresorbable bulk material and said resorbable particles, wherein the resorbable particles swell upon contact with said body fluid and cause fragmentation of said bioresorbable bulk material. - View Dependent Claims (19, 20, 21, 22, 23)
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24. A composition for use in a device in a mammal, said composition comprising:
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(a) a bioresorbable bulk material comprising an ionically or covalently crosslinked polymeric material; and
(b) resorbable particles containing an agent that causes swelling of the particles upon contact with a body fluid, said particles embedded in said bioresorbable bulk material, and said swelling of the resorbable particles causing fragmentation of said bioresorbable bulk material. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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Specification