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Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same

  • US 6,913,903 B2
  • Filed: 12/21/2001
  • Issued: 07/05/2005
  • Est. Priority Date: 09/07/2001
  • Status: Expired due to Term
First Claim
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1. A method of synthesizing an insulin polypeptide-oligomer conjugate comprising:

  • contacting a proinsulin polypeptide comprising an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer comprising a hydrophilic moiety and a lipophilic moiety under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate; and

    cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate.

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