Vitamin formulation for cardiovascular health
First Claim
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1. A composition comprising:
- (i) an amount of encapsulated Vitamin E such that when the composition is divided into unit doses each unit dose contains at least 100 International Units Vitamin E, (ii) from about 0.5% to about 10% by weight based on total weight of the composition, of precipitated silica, (iii) from about 1% to about 10% by weight, based on total weight of the composition, of calcium silicate, (iv) from about 5% to about 50% by weight, based on total weight of the composition, of microcrystalline cellulose, (v) from 0 to about 5% by weight, based on total weight of the composition, of talc; and
(vi) an amount of vitamins in addition to Vitamin E and an amount of additional minerals;
wherein the precipitated silica and the calcium silicate is present in a total amount of over 4% by weight, based on total weight of the composition;
the encapsulated Vitamin E and the total amount of silica and calcium silicate is present in a ratio of from 3;
1 to 6;
1; and
the composition is compressible into stable tablet or caplet unit doses containing the encapsulated Vitamin E in the matrix of said tablet or caplet in which no Vitamin E leaches out of encapsulated Vitamin E into the tablet or caplet matrix when the tablet or caplet is stored at room temperature for a period of at least twelve months from the date of manufacture of the tablet or caplet or when stored for three months at 40°
C. and a relative humidity of 75%.
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Abstract
The invention concerns a composition containing a high level of Vitamin E in encapsulated form, preferably as beadlets or spray dried, and a high level of silicates. The composition is compressible into tablets or caplets that do not leach out Vitamin E into the tablet matrix during compression and/or storage. The composition preferably contains vitamins and minerals in doses optimized for cardiovascular health.
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Citations
12 Claims
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1. A composition comprising:
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(i) an amount of encapsulated Vitamin E such that when the composition is divided into unit doses each unit dose contains at least 100 International Units Vitamin E, (ii) from about 0.5% to about 10% by weight based on total weight of the composition, of precipitated silica, (iii) from about 1% to about 10% by weight, based on total weight of the composition, of calcium silicate, (iv) from about 5% to about 50% by weight, based on total weight of the composition, of microcrystalline cellulose, (v) from 0 to about 5% by weight, based on total weight of the composition, of talc; and
(vi) an amount of vitamins in addition to Vitamin E and an amount of additional minerals;
wherein the precipitated silica and the calcium silicate is present in a total amount of over 4% by weight, based on total weight of the composition;
the encapsulated Vitamin E and the total amount of silica and calcium silicate is present in a ratio of from 3;
1 to 6;
1; and
the composition is compressible into stable tablet or caplet unit doses containing the encapsulated Vitamin E in the matrix of said tablet or caplet in which no Vitamin E leaches out of encapsulated Vitamin E into the tablet or caplet matrix when the tablet or caplet is stored at room temperature for a period of at least twelve months from the date of manufacture of the tablet or caplet or when stored for three months at 40°
C. and a relative humidity of 75%. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification