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Vitamin formulation for cardiovascular health

  • US 6,914,073 B2
  • Filed: 01/14/2002
  • Issued: 07/05/2005
  • Est. Priority Date: 03/18/1999
  • Status: Expired due to Fees
First Claim
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1. A composition comprising:

  • (i) an amount of encapsulated Vitamin E such that when the composition is divided into unit doses each unit dose contains at least 100 International Units Vitamin E, (ii) from about 0.5% to about 10% by weight based on total weight of the composition, of precipitated silica, (iii) from about 1% to about 10% by weight, based on total weight of the composition, of calcium silicate, (iv) from about 5% to about 50% by weight, based on total weight of the composition, of microcrystalline cellulose, (v) from 0 to about 5% by weight, based on total weight of the composition, of talc; and

    (vi) an amount of vitamins in addition to Vitamin E and an amount of additional minerals;

    wherein the precipitated silica and the calcium silicate is present in a total amount of over 4% by weight, based on total weight of the composition;

    the encapsulated Vitamin E and the total amount of silica and calcium silicate is present in a ratio of from 3;

    1 to 6;

    1; and

    the composition is compressible into stable tablet or caplet unit doses containing the encapsulated Vitamin E in the matrix of said tablet or caplet in which no Vitamin E leaches out of encapsulated Vitamin E into the tablet or caplet matrix when the tablet or caplet is stored at room temperature for a period of at least twelve months from the date of manufacture of the tablet or caplet or when stored for three months at 40°

    C. and a relative humidity of 75%.

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