Substituted porphyrins
First Claim
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1. A compound of formula wherein each R is, independently, ethyl or isopropyl, each A is, independently, hydrogen or a halogen, M is a metal selected from the group consisting of manganese, iron, copper, cobalt, and nickel, and Z−
- is a counterion.
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Abstract
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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Citations
32 Claims
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1. A compound of formula
wherein each R is, independently, ethyl or isopropyl, each A is, independently, hydrogen or a halogen, M is a metal selected from the group consisting of manganese, iron, copper, cobalt, and nickel, and Z− - is a counterion.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of protecting cells from oxidant-induced toxicity comprising contacting said cells with a protective amount of a compound of formula
wherein each R is, independently, a C1-C8 alkyl group, each A is, independently, hydrogen or a halogen, M is a metal selected from the group consisting of manganese, iron, copper, cobalt, and nickel, and Z− - is a counterion.
- View Dependent Claims (10, 11, 12, 13, 14)
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15. A method of treating a pathological condition of a patient resulting from oxidant-induced toxicity comprising administering to said patient an effective amount of a compound of formula
wherein each R is, independently, a C1-C8 alkyl group, each A is, independently, hydrogen or a halogen, M is a metal selected from the group consisting of manganese, iron, copper, cobalt, and nickel, and Z− - is a counterion.
- View Dependent Claims (16, 17, 18, 19)
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20. A method of treating a pathological condition of a patient resulting from degradation of NO·
- , comprising administering to said patient an effective amount of a compound of formula
wherein each R is, independently, a C1-C8 alkyl group, and each A is, independently, hydrogen or a halogen, M is a metal selected from the group consisting of manganese, iron, copper, cobalt, and nickel, and Z−
is a counterion. - View Dependent Claims (21, 22, 23, 24)
- , comprising administering to said patient an effective amount of a compound of formula
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25. A method of treating a patient for inflammatory lung disease comprising administering to said patient an effective amount of a compound of formula
wherein each R is, independently, a C1-C8 alkyl group, and each A is, independently, hydrogen or a halogen, M is a metal selected from the group consisting of manganese, iron, copper, cobalt, and nickel, and Z− - is a counterion.
- View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
Specification
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Current AssigneeDuke University, National Jewish Medical and Research Center
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Original AssigneeDuke University, National Jewish Medical and Research Center
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InventorsDay, Brian J., Fridovich, Irwin, Batinic-Haberle, Ines, Crapo, James D.
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Primary Examiner(s)Wilson, James O.
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Assistant Examiner(s)Habte, Kahsay
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Application NumberUS09/880,125Publication NumberTime in Patent Office1,489 DaysField of Search514/183, 514/184, 514/185, 540/145US Class Current514/183CPC Class CodesA61K 31/409 having four such rings, e.g...A61K 49/06 Nuclear magnetic resonance ...A61P 11/00 Drugs for disorders of the ...A61P 11/04 for throat disordersA61P 11/06 AntiasthmaticsA61P 29/00 Non-central analgesic, anti...A61P 37/08 Antiallergic agents antiast...A61P 39/06 Free radical scavengers or ...C07D 487/22 in which the condensed syst...
