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Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes

  • US 6,917,726 B2
  • Filed: 09/27/2002
  • Issued: 07/12/2005
  • Est. Priority Date: 09/27/2001
  • Status: Expired due to Term
First Claim
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1. A method for analysis of an analyte comprising:

  • providing a zero-mode waveguide comprising;

    a cladding surrounding a core, wherein said cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide;

    positioning the analyte in the core of the zero-mode waveguide; and

    subjecting the analyte in the core of the zero-mode waveguide to activating electromagnetic radiation of a frequency less than the cutoff frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.

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