Polypeptide arrays
First Claim
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1. A substrate with a surface comprising a plurality of polypeptides with different, known sequences bound to the surface in positionally defined locations, at a density exceeding 400 different polypeptides occupying a total area of less than 1 cm2 on said substrate, each of said polypeptides having a different polypeptide sequence.
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Abstract
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
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Citations
41 Claims
- 1. A substrate with a surface comprising a plurality of polypeptides with different, known sequences bound to the surface in positionally defined locations, at a density exceeding 400 different polypeptides occupying a total area of less than 1 cm2 on said substrate, each of said polypeptides having a different polypeptide sequence.
- 9. A substrate with a surface comprising a plurality of polypeptides with different, known sequences bound to the surface in positionally defined locations, at a density exceeding 1000 different polypeptides occupying a total area of less than 1 cm2 on said substrate, each of said polypeptides having a different polypeptide sequence.
- 14. An array of more than 1,000 different polypeptides with known sequences bound to a surface of a substrate, said polypeptides each in positionally defined locations and differing from other polypeptides in monomer sequence, each of said positionally defined locations being an area of less than about 0.01 cm2 and each positionally defined location comprising polypeptides of known sequence, said different polypeptides occupying a total area of less than 1 cm2.
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21. An array of polypeptides, said array of polypeptides comprising:
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a substrate having a surface; and
a plurality of different polypeptides bound to said surface at a density exceeding 400 different polypeptides/cm2, wherein each of said plurality of different polypeptides is attached to said surface in a different positionally defined location of area greater than 100 square, microns and has a different determinable sequence. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. An array of polypeptides, said array of polypeptides comprising:
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a planar rigid support having at least a first surface; and
a plurality of different polypeptides bound to said first surface of said planar rigid support at a density exceeding 400 different polypeptides/cm2, wherein each of said different polypeptides is attached to said first surface of said planar rigid support and has a different determinable sequence. - View Dependent Claims (40, 41)
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Specification