Therapeutic treatments for neuropsychiatric disorders
First Claim
1. A method for alleviating a symptom of a neuropsychiatric disorder, the method comprising the step of administering to a patient with a symptom of a neuropsychiatric disorder a therapeutically effective amount of a Clostridial neurotoxin, wherein the Clostridial neurotoxin is administered to an intracranial site which is associated with the symptom of the neuropsychiatric disorder, thereby alleviating the symptom of the neuropsychiatric disorder, wherein the Clostridial neurotoxin is administered to an intracranial site selected from the group of intracranial sites consisting of a locus cerulcus and a ventral tegmental area.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.
67 Citations
21 Claims
- 1. A method for alleviating a symptom of a neuropsychiatric disorder, the method comprising the step of administering to a patient with a symptom of a neuropsychiatric disorder a therapeutically effective amount of a Clostridial neurotoxin, wherein the Clostridial neurotoxin is administered to an intracranial site which is associated with the symptom of the neuropsychiatric disorder, thereby alleviating the symptom of the neuropsychiatric disorder, wherein the Clostridial neurotoxin is administered to an intracranial site selected from the group of intracranial sites consisting of a locus cerulcus and a ventral tegmental area.
- 15. A method for treating a symptom of a neuropsychiatric disorder, the method comprising the step of administering to a patient with a symptom of a neuropsychiatric disorder a therapeutically effective amount of a botulinum toxin, wherein the botulinum toxin is administered to an intracranial site which is associated with the symptom of the neuropsychiatric disorder, thereby treating the symptom of the neuropsychiatric disorder, wherein the botulinum toxin is administered to an intracranial site selected from the group of intracranial sites consisting of a locus ceruleus and a ventral tegmental area.
-
18. A method for treating of a neuropsychiatric disorder, the method comprising the step of administering to a patient with a symptom of a neuropsychiatric disorder a therapeutically effective amount of a botulinum toxin, wherein the botulinum toxin is administered to an intracranial site which is associated with the symptom of the neuropsychiatric disorder, thereby treating the symptom of the neuropsychiatric disorder by reducing neurotransmitter release from neurons contributing to the symptom of the neuropsychiatric disorder within about four months after the administration of the botulinum toxin, wherein the botulinum toxin is administered to an intracranial site selected from the group of intracranial sites consisting of a locus cerulcus and a ventral tegmental area.
- 19. A method for treating schizophrenia, the method comprising a step of administering to a patient with schizophrenia a therapeutically effective amount of a botulinum toxin, wherein the botulinum toxin is administered to an intracranial site which is associated with a symptom of schizophrenia, thereby treating schizophrenia, wherein the botulinum toxin is administered to an intracranial site selected from the group of intracranial sites consisting of a pedunculopontine nucleus, a locus ceruleus and a ventral tegmental area.
-
21. A method for treating schizophrenia the method comprising a step of administering a therapeutically effective amount of a botulinum toxin to a pedunculopontine nucleus of the brain of a patient with schizophrenia, thereby treating schizophrenia.
Specification