Bioactive coating composition and methods
First Claim
1. A coating composition for contacting surfaces of medical device, said composition comprising a molecule of Formula I:
- wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl R3 is N or O, n is a number from 1 to 10, and x is a number from 1 to about 30, bound to a heparin-activity molecule via a covalent bond, thereby forming a silyl-heparin covalent complex, with a bioactive molecule directly bound to the heparin-activity molecule.
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Abstract
The present invention provides a bioactive coating composition, method and devices for bodily fluid-contacting surfaces. The coating comprises a complex of Formula II: wherein R1 is an C1-18alkyl or C6-32aryl group, each R2 is independently selected from the group consisting of C1-18alkyl and C6-32aryl, R3 is N or O, n is a number from 1 to 10, and x in a number from 1 to about 30, directly bound to a heparin-activity molecule via covalent bonding, with one or more bioactive molecules bound to the heparin-activity molecule. The bioactive molecule may be an adhesive molecule such as fibronectin, a growth factor such as basic fibroblast growth factor, or any other bioactive molecule that binds, by any mechanism, to a heparin-activity molecule
208 Citations
29 Claims
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1. A coating composition for contacting surfaces of medical device, said composition comprising a molecule of Formula I:
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wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl R3 is N or O, n is a number from 1 to 10, and x is a number from 1 to about 30, bound to a heparin-activity molecule via a covalent bond, thereby forming a silyl-heparin covalent complex, with a bioactive molecule directly bound to the heparin-activity molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A medical device with at least one contacting surface for contacting bodily fluids, the surface having coated thereon a coating composition comprising a molecule of Formula I:
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wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, and x is a number from 1 to about 30, directly bound to a heparin-activity molecule via covalent bonding, thereby forming a silyl-heparin covalent complex, with a bioactive molecule directly bound to the heparin-activity molecule. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for coating a contacting surface of a medical device with a bioactive coating composition, comprising:
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providing a hydrophobic silyl moiety of Formula I
whereinR1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, and n is a number from 1 to 10 binding said silyl moiety to a heparin-activity molecule via covalent bonding, wherein x is from 1 to about 30 for each heparin-activity molecule, thereby forming a silyl-heparin complex, attaching the silyl-heparin complex to the contacting surface by hydrophobic interaction, and attaching a bioactive molecule to the heparin-activity molecule. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
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Specification