Method for measuring tissue morphology
First Claim
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1. A method of endoscopically measuring a size of a structure in a layer of tissue comprising:
- directing radiation having a plurality of wavelengths in a range between 350 nm and 700 nm through an endoscope onto a region of interest in the layer of tissue;
collecting radiation from the tissue;
detecting the collected radiation to provide a detected spectrum; and
determining a size of a structure within the tissue layer from the detected spectrum.
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Abstract
The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
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Citations
34 Claims
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1. A method of endoscopically measuring a size of a structure in a layer of tissue comprising:
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directing radiation having a plurality of wavelengths in a range between 350 nm and 700 nm through an endoscope onto a region of interest in the layer of tissue;
collecting radiation from the tissue;
detecting the collected radiation to provide a detected spectrum; and
determining a size of a structure within the tissue layer from the detected spectrum. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of optically measuring a physical characteristic of tissue comprising:
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A directing radiation having a plurality of wavelengths in a range between 350 nm and 700 nm through an endoscope onto a region of interest in tissue to be measured;
collecting radiation from the tissue; and
measuring a periodic component of collected radiation as a function of wavelength to determine a physical characteristic of the tissue. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method of determining a presence of dysplasia in tissue comprising:
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directing radiation having a plurality of wavelengths in a range between 350 nm and 700 nm through an endoscope onto a region of interest in an epithelial layer of tissue such that radiation is backscattered by the tissue;
collecting the backscattered radiation from the tissue;
detecting the collected backscattered radiation with a detector to provide a scattering spectrum; and
determining the presence of dysplasia in the region of interest of the tissue with the scattering spectrum. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25. A method of optically measuring a physical characteristic of a material comprising:
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directing radiation having a plurality of wavelenths in a range between 350 nm and 700 nm through an endoscope onto a region of interest in the material tissue to be measured;
collecting radiation from the material;
detecting a scattering spectrum from the collected radiation; and
measuring a periodic component from the scattering spectrum as a function of wavelength to determine a physical characteristic of the material. - View Dependent Claims (26, 27, 28, 29)
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30. An endoscope apparatus for optically measuring a physical characteristic of tissue comprising:
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a radiation source that illuminates a region of interest in tissue to be measured through an endoscope with radiation having a plurality of wavelengths in a range between 350 nm and 700 nm;
an optical system in the endoscope that collects radiation from the tissue;
a detector system that senses the collected radiation; and
a data processor that determines a periodic component of detected radiation as a function of wavelength to determine a physical characteristic of the tissue. - View Dependent Claims (31, 32, 33, 34)
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Specification