Chondroprotective/restorative compositions and methods of use thereof
First Claim
1. An orally administrable Chondroprotective/Restorative composition in gel or paste form for administration to a mammal comprising an effective amount Hyaluronic Acid or its pharmaceutically acceptable salts an a pharmaceutically acceptable gelling or pasting agent capable of forming a gel or a paste selected from the group consisting of hydroxypropyl methyl cellulose, hydroxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate, ethyl cellulose, methyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, cellulose gum carboxymethylcellulose, sodium carboxymethylcellulose and molasses.
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Abstract
The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid, said method comprising orally administering to a mammalian species a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof. Additionally, compositions containing hyaluronic acid; chondroitin sulfate, and glucosamine sulfate in a paste formulation are also disclosed which can be administered on their own or can be used as a feed additive.
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Citations
28 Claims
- 1. An orally administrable Chondroprotective/Restorative composition in gel or paste form for administration to a mammal comprising an effective amount Hyaluronic Acid or its pharmaceutically acceptable salts an a pharmaceutically acceptable gelling or pasting agent capable of forming a gel or a paste selected from the group consisting of hydroxypropyl methyl cellulose, hydroxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate, ethyl cellulose, methyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, cellulose gum carboxymethylcellulose, sodium carboxymethylcellulose and molasses.
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3. An orally administrable Chondroprotective/Restorative composition comprising:
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(a) an effective amount of Glucosamine sulfate;
(b) an effective amount Hyaluronic Acid or pharmaceutically acceptable salts thereof; and
(c) a pharmaceutically acceptable gelling or pasting agent capable of forming a gel or a paste selected from the group consisting of hydroxypropyl methyl cellulose, hydroxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate, ethyl cellulose, methyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, cellulose gum carboxymethylcellulose, sodium carboxymethylcellulose and molasses. - View Dependent Claims (4)
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5. An orally administrable Chondroprotective/Restorative composition comprising
(a) an effective amount of Chondroitin sulfate; -
(b) an effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof; and
(c) a pharmaceutically acceptable gelling or pasting agent capable of forming a gel or a paste selected from the group consisting of hydroxypropyl methyl cellulose, hydroxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate, ethyl cellulose, methyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, cellulose gum carboxymethylcellulose, sodium carboxymethylcellulose and molasses. - View Dependent Claims (6)
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7. An orally administrable Chondroprotective/Restorative composition comprising
(a) an effective amount of Glucosamine sulfate; -
(b) an effective amount of Chondroitin sulfate;
(c) an effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof; and
(d) a pharmaceutically acceptable gelling or pasting agent capable of forming a gel or a paste selected from the group consisting of hydroxypropyl methyl cellulose, hydroxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate, ethyl cellulose, methyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, cellulose gum carboxymethylcellulose, sodium carboxymethylcellulose and molasses. - View Dependent Claims (8)
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9. A therapeutic and Chondroprotective/Restorative composition in gel form for oral administration comprising:
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(a) an effective amount of hyaluronic Hyaluronic Acid or its pharmaceutically acceptable salts;
(b) an effective amount of a therapeutic drug; and
(c) a pharmaceutically acceptable gelling or pasting agent capable of forming a gel or a paste selected from the group consisting of hydroxypropyl methyl cellulose, hydroxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, cellulose acetate, ethyl cellulose, methyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, cellulose gum carboxymethylcellulose, sodium carboxymethylcellulose and molasses. - View Dependent Claims (10)
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11. An oral Chondroprotective/Restorative composition in paste from comprising:
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(a) an effective amount of Hyaluronic Acid or its pharmaceutically acceptable salts; and
(b) a sufficient amount of molasses to make a paste. - View Dependent Claims (12, 13, 14)
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15. An orally administrable Chondroprotective/Restorative composition in gel form comprising:
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(a) an effective amount of Hyaluronic Acid or its pharmaceutically acceptable salts;
(b) water; and
(c) a sufficient amount of carboxymethylcellulose or its sodium salt to make a gel. - View Dependent Claims (16, 17, 18, 19)
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Specification