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Albumin fusion proteins

  • US 6,926,898 B2
  • Filed: 04/12/2001
  • Issued: 08/09/2005
  • Est. Priority Date: 04/12/2000
  • Status: Expired due to Term
First Claim
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1. An albumin fusion protein comprising a member selected from the group consisting of:

  • (a) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2) and albumin, wherein albumin comprises the amino acid sequence of SEQ ID NO;

    18;

    (b) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2) and a fragment of the amino acid sequence of SEQ ID NO;

    18, wherein said fragment of the amino acid sequence of SEQ ID NO;

    18 has the ability to prolong the shelf-life of the antibody or antibody fragment that specifically binds HER2, compared to the shelf-life of the antibody or antibody fragment that specifically binds HER2, in an unfused state;

    (c) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2) and a fragment of the amino acid sequence of SEQ ID NO;

    18, wherein said fragment has the ability to prolong the shelf-life of the antibody or antibody fragment that specifically binds HER2 compared to the shelf-life of the antibody or antibody fragment that specifically binds HER2, in an unfused state, and further wherein the said fragment comprises amino acid residues 1-387 of SEQ ID NO;

    18;

    (d) a fragment of an antibody that specifically binds human epidermal growth factor receptor-2 (HER2) and albumin comprising the amino acid sequence of SEQ ID NO;

    18, wherein said fragment has a biological activity of the antibody that specifically binds HER2;

    (e) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2), and albumin, or fragment thereof, of (a) to (d), wherein the antibody or antibody fragment that specifically binds HER2, is fused to the N-terminus of albumin or the N-terminus of the fragment of albumin;

    (f) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2), and albumin, or fragment thereof, of (a) to (d), wherein the antibody or antibody fragment that specifically binds HER2, is fused to the C-terminus of albumin, or the C-terminus of the fragment of albumin;

    (g) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2), and albumin or fragment thereof, of (a) to (d), wherein the an antibody or antibody fragment that specifically binds HER2, is fused to the N-terminus and C-terminus of albumin, or the N-terminus and the C-terminus of the fragment of albumin;

    (h) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2), and albumin or fragment thereof, of (a) to (g), wherein the an antibody or antibody fragment that specifically binds HER2, is separated from the albumin or the fragment of albumin by a linker; and

    (i) an antibody or antibody fragment that specifically binds human epidermal growth factor receptor-2 (HER2), and albumin or fragment thereof, of (a) to (h), wherein the albumin fusion protein has the following formula;


    R1-L-R2;

    R2-L-R1;

    or R1-L-R2-L-R1, and further wherein R1 is an antibody or antibody fragment that specifically binds HER2, L is a peptide linker, and R2 is albumin comprising the amino acid sequence of SEQ ID NO;

    18 or a fragment of albumin.

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