Internal drug dispenser capsule medical device

• US 6,929,636 B1
• Filed: 11/08/2000
• Issued: 08/16/2005
• Est. Priority Date: 11/08/2000
• Status: Expired due to Fees

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: von Alten, Thomas W.
• Primary Examiner(s): Mendez, Manuel
• Application Number:
  US09/710,028
• Time in Patent Office: 1,742 Days
• Field of Search: 604/114, 604/113, 604/65, 604/66, 604/67, 604/891.1, 604/892.1, 604/890.1, 604 19- 21, 604 30- 31, 604/151
• US Class Current: 604/890.1
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61J 3/007 Marking tablets or the like apparatus for printing on tablets or the like B41F17/36
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/4808 characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release capsules filled with granules or microparticles A61K9/16; filled with microcapsules or coated microparticles A61K9/50; with mixture of different granules, microcapsules, (coated) microparticles A61K9/5084
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2210/1042 Alimentary tract A61M2210/0618 takes precedence
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: G11B 9/14 using microscopic probe means , i.e. recording or reproducing by means directly associated with the tip of a microscopic electrical probe as used in Scanning Tunneling Microscopy [STM] or Atomic Force Microscopy [AFM] for inducing physical or electrical perturbations in a recording medium; Record carriers or media specially adapted for such transducing of information marking using electrical current B41M5/20; measuring roughness or irregularity of surfaces G01B7/34; details of scanning-probe microscopes G01Q

Abstract

The present invention provides a swallowable internal drug medical device. The device includes a swallowable capsule. A sensing module is disposed in the capsule. A bioactive substance dispenser is disposed in the capsule. A memory and logic component is disposed in the capsule and in communication with the sensing module and the dispenser.

Claims

1. A swallowable internal drug medical device comprising:

a swallowable capsule including;

a sensing module configured to sense a biologic condition within a digestive tract;

a bioactive substance dispenser including a container for holding a volume of bioactive substance and a microactuator configured to dispense the bioactive substance from the container; and

a memory and logic component in communication with the sensing module and the dispenser, including at least one of stored data of biologic conditions in the digestive tract and stored predetermined criteria for dispensing, the memory and logic component being configured to trigger the microactuator of the dispenser to dispense the bioactive substance when the sensed bodily condition corresponds to at least one of the stored data and the stored predetermined criteria.

2. The device of claim 1, wherein the capsule comprises a shell having a first portion and a second portion wherein the first portion is hingedly connected to the second portion and the second portion defines the bioactive substance container.

3. The device of claim 2, wherein the microactuator comprises a releasably fusible link disposed at a surface of the shell releasably securing the first portion to the second portion and being selectively actuable to selectively release the bioactive substance from the shell.

4. The device of claim 1, wherein the sensing module comprises at least one of a pH sensor, a temperature sensor, a glucose sensor, and a phenylalanine sensor.

5. The device of claim 1, wherein the memory and logic component comprises a programmable logic controller.

6. The device of claim 1, wherein the memory and logic component has a capacity of at least 10 megabytes.

7. The device of claim 1, wherein the memory and logic component has a power consumption of no more than 500 mW.

8. The device of claim 1, wherein the stored data of biologic conditions in the memory and logic component comprises a profile of predetermined values for a plurality of known biologic conditions.

9. The device of claim 1, further comprising:

a remote ultrasonic transmission and receiver unit for location outside of a body; and

an ultrasonic transmission and receiver unit disposed within the capsule and in communication with the remote unit;

wherein the ultrasonic transmission and receiver unit is capable of transmitting sensed biologic data to the remote unit and the remote unit is capable of transmitting signals to the memory and logic component to trigger the microactuator of the bioactive substance dispenser, in cooperation with the memory and logic component, to dispense the bioactive substance from the container into the digestive tract.

10. The device of claim 1, further comprising a power supply connected to the memory and logic component.

11. The device of claim 1, wherein the sensing module comprises an array of sensors with each sensor detecting a different biologic condition.

12. The device of claim 1, wherein the sensing module comprises an array of sensors with each sensor detecting a different predetermined value of the same biologic condition.

13. The device of claim 1 wherein the microactuator is configured to initiate dispensing the bioactive substance without communication to a device external of the capsule.

14. The device of claim 1 wherein the microactuator is configured to initiate dispensing the bioactive substance independent of a device outside of the capsule.

15. The device of claim 1 wherein the sensed biologic condition corresponds to a known body location at which the bioactive substance is to be dispensed.

16. The device of claim 1 wherein the memory and logic component is configured to cause the microactuator to dispense the bioactive substance at a predetermined continuously variable rate in which the rate increases as a value of the sensed biologic condition increases and the predetermined continuously variable rate decreases as the value of the sensed biologic condition decreases.

17. The device of claim 1 wherein the memory and logic component is configured to cause the microactuator to dispense the bioactive substance at a predetermined continuously variable rate in which the rate decreases as a value of the sensed biologic condition increases and the predetermined continuously variable rate increases as the value of the sensed biologic condition decreases.

18. The device of claim 1 wherein the memory and logic component is configured to cause the microactuator to dispense the bioactive substance after a predetermined amount of time in the digestive tract and upon the sensed biologic condition sustaining a predetermined value for a predetermined amount of time.

19. A swallowable capsule comprising:

means for sensing biologic conditions within a digestive tract;

means for maintaining stored information about a plurality of bodily conditions within a digestive tract; and

means for dispensing a drug from the capsule within the digestive tract, in communication with the means for sensing and the means for maintaining stored information, acting to dispense the drug based upon the biologic conditions sensed by the means for sensing and based upon the stored information in the means for maintaining stored information.

20. The swallowable capsule of claim 19, wherein the means for sensing comprises at least one of a pH sensor, a temperature sensor, a glucose sensor, and a phenylanine sensor.

21. The swallowable capsule of claim 19, wherein the means for sensing comprises an array of sensors with each sensor detecting a different biologic condition.

22. The swallowable capsule of claim 19, wherein the means for dispensing a drug acts to dispense the drug without communication to a device external of the capsule.

23. The swallowable capsule of claim 19, wherein the means for dispensing a drug acts to dispense the drug when the biologic conditions sensed by the means for sensing corresponds to a known body location at which the drug is to be dispensed.

24. The swallowable capsule of claim 23, wherein the means for dispensing comprises a container for holding a volume of the drug and a microactuator configured to dispense the drug from the container upon the sensed biologic conditions corresponding to the stored information.

25. The swallowable capsule of claim 24, wherein the container comprises a first portion and a second portion releasably secured to the first portion via a fusible link at a hinged connection between the first portion and the second portion and the microactuator is configured to cause dispensing of the drug from the container by actuating release of the fusible link to open the first portion relative to the second portion at the hinged connection.