Targeted therapeutic delivery of vitamin D compounds
First Claim
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1. A conjugate comprising 1α
- -(OH)-24-aminoalkyl-1,1-bisphosphonate-D2, 1-aniinoalkyl-1,1-bisphosphonate-24-(OH)-D2, 1α
,24-(OH)2-3-aminoalkyl-1,1-bisphosphonate-D2, 1α
-aminoalkyl-1,1-bisphosphonate-25-(OH)-D3, 1α
,25-(OH)2-3-aminoalkyl-1,1-bisphosphonate-D3, 1α
-(OH)-25-aminoalkyl-1,1-bisphosphonate-D3, or a combination thereof.
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Abstract
The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.
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Citations
6 Claims
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1. A conjugate comprising 1α
- -(OH)-24-aminoalkyl-1,1-bisphosphonate-D2, 1-aniinoalkyl-1,1-bisphosphonate-24-(OH)-D2, 1α
,24-(OH)2-3-aminoalkyl-1,1-bisphosphonate-D2, 1α
-aminoalkyl-1,1-bisphosphonate-25-(OH)-D3, 1α
,25-(OH)2-3-aminoalkyl-1,1-bisphosphonate-D3, 1α
-(OH)-25-aminoalkyl-1,1-bisphosphonate-D3, or a combination thereof.
- -(OH)-24-aminoalkyl-1,1-bisphosphonate-D2, 1-aniinoalkyl-1,1-bisphosphonate-24-(OH)-D2, 1α
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2. A pharmaceutical composition comprising:
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a conjugate comprising 1α
-(OH)-24-aminoalkyl-1,1-bisphosphonate-D2, 1-aminoalkyl-1,1-bisphosphonate-24-(OH)-D2, 1α
,24-(OH)2-3-aminoalkyl-1,1-bisphosphonate-D2, 1α
-aminoalkyl-1,1-bisphosphonate-25-(OH)-D3, 1α
,25-(OH)2-3-aminoalkyl-1,1-bisphosphonate-D3, 1α
-(OH)-25-aminoalkyl-1,1-bisphosphonate-D3, or a combination thereof, anda suitable pharmaceutically acceptable carrier. - View Dependent Claims (3, 4, 5, 6)
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Specification