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Porous drug matrices and methods of manufacture thereof

  • US 6,932,983 B1
  • Filed: 11/03/2000
  • Issued: 08/23/2005
  • Est. Priority Date: 05/27/1999
  • Status: Expired due to Fees
First Claim
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1. A method of delivering a drug to a patient in need thereof, comprisingadministering a therapeutically or prophylactically effective amount of the drug in a formulation comprising a porous matrix which comprises a wetting agent and microparticles of the drug, wherein the microparticles have a mean diameter between about 0.1 and 5 μ

  • m and a total surface area greater than about 0.5 m2/mL, and wherein the porous matrix has a TAP density less than or equal to 1.0 g/mL or has a total surface area of greater than or equal to 0.2 m2/g and is in the form of a dry powder, and wherein the porous matrix is made by a process comprising, dissolving the drug in a volatile solvent to form a drug solution, combining at least one volatile salt with the drug solution to form an emulsion, suspension, or second solution, incorporating at least one wetting agent into the emulsion, suspension, or second solution, and removing the volatile solvent and volatile salt from the emulsion, suspension, or second solution to yield the porous matrix.

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