Device for mass transport assisted optical assays
First Claim
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1. A support comprising a surface on which an assay for an analyte of interest can be performed, comprising:
- an attachment layer comprising diamond-like carbon having sp2 and sp3 character on the support surface, wherein the attachment layer is adapted for capture of the analyte of interest for detection in the assay by binding the analyte directly to the diamond-like carbon; and
an optically functional layer, an optical property of which is detectably altered upon a change in mass on said optically functional layer related to analyte binding, positioned on said support.
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Abstract
An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
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Citations
33 Claims
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1. A support comprising a surface on which an assay for an analyte of interest can be performed, comprising:
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an attachment layer comprising diamond-like carbon having sp2 and sp3 character on the support surface, wherein the attachment layer is adapted for capture of the analyte of interest for detection in the assay by binding the analyte directly to the diamond-like carbon; and
an optically functional layer, an optical property of which is detectably altered upon a change in mass on said optically functional layer related to analyte binding, positioned on said support. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A support comprising a surface on which an assay for an analyte of interest can be performed, comprising:
an attachment layer comprising a layer of diamond-like carbon having sp2 and sp3 character of between about 50 Å
to about 500 Å
in thickness on the support surface, wherein said attachment layer comprises a capture molecule bound to said diamond-like carbon for specific capture of said analyte by binding said analyte to said capture molecule.- View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
Specification